SVIBOR - Project code: 3-01-207

MINISTRY OF SCIENCE AND TECHNOLOGY

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Project code: 3-01-207

Immunity in children with brain tumor

Main researcher: HAJNŽIĆ, TOMISLAV FRANJO (97390)

Assistants

LUKAČ, JOSIP (26756)

Type of research: applied
Duration from: 01/01/91. to 12/31/94.

Papers on project (total): 26
Papers on project quoted in Current Contents: 10

Institution name: Bolnica "Sestre milosrdnice", Zagreb (134)
Department/Institute: Department of Pediatrics and Department of Nuclear Medicine and Oncology Sestre milosrdnice Clinical Hospital
Address: Vinogradska 29 41000 Zagreb,R.Hrvatska

Communication

Summary: Immunological abnormalities often seen in neoplastic diseases are considered responsible for increased infection rate and more frequent appearance of malignant disease relapses.In this study specific reactions mediated by T lymphocytes,as well as nonspecific reactions,mediated by natural killer cells,monocytes and granulocytes were determined in 39 patients with brain tumor (BT).The same parameters of general immunocompetence were determined in 18 healthy children.The results have shown that patients with malignant BT have initialy significant depression of immunity.In contrast to BT patients who did not take immuno- modulating drug levamisole,the levamisole-treated BT children displayed a visible improve of immunostatus.The incidence of infection has been diminished during the administrationm of levamisole.

Keywords: Immunity,children,brain tumor,levamisole,T,B-lymphocyte,phagocytosis,granulocyte,monocyte ,NK cell activity,LGL.

Research goals: A prospective study of the dynamics of range of general immunocompetence(IC)in children with brain tumor(BT) has been conducted.The general IC parameters were determined in patients(ptc) aged 2-l4 years after neurosurgery,before and during chemotherapy.Ptc with malignant BT have initialy depression of phagocytic activity,the proportion and absolute number of LGL,NK cell activity and the blastogenic transformation of lymphocytes after mitogen stimulation.Ptc with higher initial level of IC had better prognosis with longer duration of remission.Levamisole used as an adjuvant immunomodulating drugs during chemotherapy period stimulate immune response in immunocompromised pts with BT The incidence of infection has been diminmished during the administration of levamisole.

Other information about the project.


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