SVIBOR - Papers quoted in CC - project code: 3-01-219
MINISTRY OF SCIENCE AND TECHNOLOGY
Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr
SVIBOR - Collecting Data on Projects in Croatia
Papers quoted in Current Contents on project 3-01-219
Quoted papers: 2
Other papers: 9
Total: 11
Title: Quality control program of steroid receptor assays: an
international study
- Authors:
- Vermousek, I.
- Szamel, I.
- Goerlich, M.
- Brdar, Branko
- Cvrtila, Dragutin (59441)
- Graf, D.
- Padovan, Radovan
- Paszko, Z.
- Šafarčik, K.
Journal: Neoplasma
Number: 1
ISSN: 0028-2685
Volume: 39
Year: 1992
Pages: from 65 to 69
Number of references: 10
Language: engleski
Summary: Lyophilized cytosol and tissue powder standards were
prepared forquality control of estrogen receptor (ER) and
progesteronreceptor (PR) determination. Coefficient of variation (CV) of
thebetween-laboratory averages of positive standards varied from29.6 to
61.8% and from 32.4 to 76.2%, respectively. Alllaboratories, with the
exception of a single value, couldrecognize samples of low, medium, and
high ER level, as well as anegative sample. Most laboratories evaluated
properly also thelevel of PR samples.
Keywords: Quality control, ER assay, PR assay, interlaboratory comparative study
Title: IMMUNOHISTOCHEMICAL DETECTION OF TGF-ALFA, EGF-R,
c-erbB-2, c-H-ras, c-myc, ESTROGEN AND PROGESTERONE RECEPTORS IN BENIGN AND
MALIGNANT HUMAN BREAST LESIONS: A CONCOMITANT EXPRESSION
- Authors:
- Spaventi, Radan
- Kamenjicki, Elena
- Pećina, Nives
- Grazio, Simeon
- Grazio, Snježana
- Pavelić, Jasminka
- Kušić, Borka
- Cvrtila, Dragutin (59441)
- Danilović, Žarko
- Spaventi, Šime
- Pavelić, Krešimir
- Gluckman, Jack
- Pavelić, Zlatko P.
Journal: In vivo
ISSN: 0258-851X
Volume: 8
Year: 1994
Pages: from 183 to 190
Number of references: 63
Language: engleski
Summary: The expression of transforming growth factor-alpha
(TGF-alpha), epidermalgrowth factor receptor (EGF-R) and oncogenes
c-erbB-2, c-H-ras, c-myc, as well as estrogen (ER) and progesterone (PR)
receptors were studied immunohistochemicallz in the tissue of 21 benignand
58 malignant human breast lesions. Twenty nine (50%) of 58 carcinomas were
positive for EGF-R and c-erbB-2 product, 55 (94.8%) for c-myc product, 9
(15.5%) for c-H-ras product and 17 (29%) for TGF-alpha. Eighteen of 58
(31%) carcinomas were estrogen receptor positive and 22 (38%) were positive
for progesterone receptor. No correlation was found between expression of
each investigated parameter and the clinical stage or degree of
histological differentiation of the carcinomas. However, a significant
positive correlation was observed between lymph node involvement and
c-erbB-2 and EGF-R/c-erbB-2 positive tumors. A strong correlation was also
observed between high levels of EGF-R and low levels of estrogen receptor.
In 15 of 17 cases we found simultaneous expression of EGF-R i TGF-alpha. We
also found interesting patterns in concomitant expression of the
investigated parameters suggesting a possible cascade of events that occur
in breast cancer cells.
Keywords: TGF-alpha, EGF-R, c_erbB-2, c-H-ras, c-myc, progesterone, estrogen, breast lesions
Information: svibor@znanost.hr
