SVIBOR - Project code: 3-01-219

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-219


RECEPTORS, GROWTH FACTORS AND MARKERS IN SOLID TUMORS


Main researcher: CVRTILA, DRAGUTIN (59441)



Assistants
Type of research: applied
Duration from: 06/01/91. to 12/31/95.

Papers on project (total): 11
Papers on project quoted in Current Contents: 2
Institution name: Bolnica "Sestre milosrdnice", Zagreb (134)
Department/Institute: Department of oncology and nuclear medicine
Address: Vinogradska c. 29
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)1 17 46 66

Summary: In 689 breast cancer patients in longitudinal study the concentrations of tumor markers CA 15-3, CEA, CA M26 and CA M29 along with estrogen and progestin receptors were determined. In 53 patients suffering from ovarial carcinoma and in 36 patients with endometrial cancer the concentration of tumor marker CA 125 along with estrogen and progestin receptors were determined. In breast cancer patients without the evidence of metastasis (disease free interval) tumor markers were mostly normal. The ability to detect advanced disease in an order of decreasing sensitivity was CA 15-3 > CEA > CA M29 > CA M26 (0.61, 0.53, 0.51, 0.47, respectively). Markers CA M26 and CA M29 combined together exhibit lower sensitivity (0.71) than CA 15-3 and CEA (0.79), but this was accomplished with better specificity. All markers varied in accordance with the obvious disease status changes in greater or lesser extent. Estrogen and progestin receptor concentrations in endometrial tissue samples were the highest in hyperplastically altered tissue and the lowest in carcinomatous tissue. Results suggest strong hormonal activity in precancerous tissue. In patients with ovarial cancer marker CA 125 have shown very good concordance with the disease progression or regression.

Keywords: Steroid receptors, growth factors, tumor markers, breast, ovary, endometrium

Research goals: In this study we will determine concentrations of various parameters such as estrogen and progestin receptors, and tumor markers CEA, CA 15-3, CA M26, CA M29, CA 125 and osteocalcin in patients who suffer from breast, ovary and endometrial carcinoma. Determining the presence and concentration of receptors in tumor tissues we hope to have the answer to the question if these parameters could be connected with disease-free interval. Also, we want to know the relationship between disease-free interval and tumor marker levels. A multiple marker breast cancer panel will be used to monitor patients in the longitudinal study. The data will show the relationship between tumor marker levels and disease progression, regression or stability.

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Last update: 10/04/95
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