SVIBOR - Project code: 3-01-221

MINISTRY OF SCIENCE AND TECHNOLOGY

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Project code: 3-01-221


THE ASSESSMENT OF CEREBRAL VASOREACTIVE CAPACITY BY TRANSCRANIAL DOPPLER


Main researcher: DEMARIN, VIDA (39356)


Assistants
Type of research: applied
Duration from: 01/01/91. to 12/31/93.
Papers on project (total): 157
Papers on project quoted in Current Contents: 26
Institution name: Bolnica "Sestre milosrdnice", Zagreb (134)
Department/Institute: UNIVERSITY CLINIC OF NEUROLOGY
Address: VINOGRADSKA C.29
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (41) 174 666
Fax: 385 (41) 172 453
Fax: 385 (1) 574 291
Phone: 385 (1) 574 291
Summary: Cerebral autoregulation is protective, physiologic regulatory mechanism which provides constant cerebral blood flow despite of huge variations of perfusion pressure. The majority of investigations of cerebral autoregulation has been done on animal models and therefore their results can not be applied on humans. Up to now cerebral autoregulation and vasoreactivity were examined by invasive and expensive methods such as rCBF, SPECT and PET. Recent advances in medical technology and use of non-invasive Doppler sonography methods enabled the possibility of simple, accurate and reliable measurements of cerebral autoregulatory capacity in humans. This study was aimed to assess autoregulatory limits and vasoreactive capacity in healthy people, in those with already present risk factors for cerebrovascular disease and in those with hemodynamic disturbances in order to predict and prevent further brain damage. Such investigation would also give a new approach to the evaluation of the cerebral hemodynamic impairment. It is not only important to assess the degree of extracranial or intracranial cerebrovascular disturbances and the way of cerebrovascular protection, but also whether this protection is still efficient or not, evaluating the quantity of hemodynamic reserve.

Keywords: Transcranial Doppler, Extracranial Doppler, Cerebral Autoregulatory Capacity, Cerebral Vasoreactivity, Physiologic Tests, Acetazolamide Test

Research goals: Existing knowledge of patophysiological mechanisms of cerebral circulation in humans are controversial. Therefore, the aim of our investigation was to assess cerebral autoregulatory capacity in physiologic conditions related to age and gender and in some pathologic conditions related to etiopathogenesy. The main hypothesis of this investigation is that cerebral autoregulatory capacity is sufficient enough to maintain a huge variation of perfusion pressure and remain constant despite of large variations of physiological stimuli. On the contrary, in impaired cerebral circulation regardless the cause, the cerebral vasoreactive capacity is decreased or completely exhausted. The specific aims of our study are to assess the limits of cerebral autoregulatory capacity and cerebral vasoreactivity in: a) healthy subjects related to age and gender, b) in those with certain risk factors, and c) in those with pathologic hemodynamic impirment. Concerning the different tests for the assessment of cerebral autoregulatory capacity the next step is to assess the most suitable test for cerebral vasoreactivity concerning the following advantages: noinvasivity, simplicity, duration of testing, accuracy, specificity and sensitivity, reporducibility,and cost-effectivness. The obtained results would allowe the differentiation between impaired autoregulatory capacity especially in order to predict the risk for cerebral damage contibuting to prognosis and prevention. Thus, in "Decade of the brain" proclaimed by World Federation of Neurology, our investigation joins the others which are aimed to investigate and spread the world knowledge of brain functioning.

COOPERATION - PROJECTS


  1. Name of project: HEALTHY LIFESTYLE AND PREVENTION OF STROKE
    Name of institution: CLINICA TEKNON - BARCELONA, ŠPANJOLSKA
    City: 20000 - Dubrovnik, Croatia

  2. Name of project: EMBOLI DETECTION BY TRANSCRANIAL DOPPLER
    Name of institution: LUDWIG MAXIMILLIAN UNIVERSITY MUNCHEN, NJEMAČKA
    City: MINHEN, NJEMAČKA

  3. Name of project: FOLLOW-UP OF MID AND DAT PATIENTS
    Name of institution: SEMELWEISS UNIVERSITY BUDAPEST, MADŽARSKA
    City: BUDAPEST, MADŽARSKA

  4. Name of project: HEADACHE AND PAIN
    Name of institution: THE DEBIO GROUP, LAUSANNE, ŠVICARSKA
    City: LAUSANNE, ŠVICARSKA

COOPERATION - INSTITUTIONS


  1. Name of institution: CLINIC TEKNON BARCELONA
    Type of institution: Other
    Type of cooperation: Occasional exchange of information
    City: BARCELONA, ŠPANJOLSKA

  2. Name of institution: LUDWIG MAXIMILLIAN UNIVERSITY MUNCHEN
    Type of institution: University/Faculty
    Type of cooperation: Joint project
    City: MINHEN, NJEMAČKA

  3. Name of institution: SEMELWEISS UNIVERSITY BUDAPEST
    Type of institution: University/Faculty
    Type of cooperation: Occasional exchange of information
    City: BUDAPEST, MADŽARSKA

  4. Name of institution: THE DEBIO GROUP LAUSANNE
    Type of institution: Economical/Production
    Type of cooperation: Joint project
    City: LAUSANNE, ŠVICARSKA
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