Type of research: applied Duration from: 04/30/91. to 04/30/94. Papers on project (total): 31
Papers on project quoted in Current Contents: 8
Institution name: Bolnica "Sestre milosrdnice", Zagreb (134) Department/Institute: Department of Oncology and Nuclear Medicine Address: Vinogradska c. 29 City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)41 57 58 34
Fax: 385 (0)41 57 28 88
Summary: Prior to the introduction of iodine prophylaxis (1953.) in
Croatia, in some parts of the country the prevalence of endemic goiter
among the school-children was from 45% to 85%. This measure resulted 10
years later in a significant reduction of goiter prevalence to 21-45%. In
Croatia the estimation of endemic goiter has not been carried out recently,
but clinical data still inidicate further persistence of goiter prevalence.
Due to this fact the objectives of the project are: evaluation of the
goiter prevalence in Croatia, finding out whether the increased prevalence
still persists as a result of reduced iodine intake by the organism and
finally eradication of the endemic goiter as a public health problem.
Epidemiological investigations on 3400 school children aged 7-15 years will
be included into the study. The examination of children will be primarily
carried out in previously goitrogenous regions of Zagreb and northwest
Croatia: Samobor - Rude; Slavonia (eastern part of the country): Đakovo,
Osijek; Primorje (northern Adriatic coast area) and Gorski Kotar: Delnice,
Rijeka, island Krk; Dalmatia (southern Croatia) and Zagora: Lovreć, Split
and island Brač. Goiter size will be estimated by palpation and classified
by Pan American Health Organization and Worl Health Organization (WHO)
criteria. Until now the prevalence of goiter was assesed by neck palpation
of a total of 2821 school-children in 9 communities. The overall prevalence
varied from 8% to 36% (Split 8%, Supetar 10%, Rijeka 13%, Lovreć 14%,
Zagreb 19%, Đakovo 22%, Osijek 28%, Krk 32% and Rude 36%). Thyroid volume
determined by USG in 13 years old children in Zagreb was 10,2 +/- 2,3 mL
(two fold biger than in Sweden), while measured iodine excretion in Zagreb
school children had low border value with median of 9,0 ug/dL. It is also
planed to measure serum level of T3, T4 and TSH in some patients (by
sensitive method) as well as to determinate TSH level in newborns. Beside
that in some patients with goiter and healthy volunteers the immunological
competence is going to be evaluated in order to determine possible
immunological disturbances caused by iodine deficiency.
Research goals: Iodine deficiency is a major public health problem.
Besideendemic goiter and cretenism, a number of disorders may be causedby
severe iodine deficiency in the organism: lower fertilityrate, increased
miscarriage and still-born incidence, congenitalanomalies, perinatal
mortality rate, retardation in body andmental development and tyroid
insufficiency. The main goal of ourproject is to evaluate goiter
prevalence in Croatia and to findout if the increased prevalence still
persists as a result ofreduced iodine intake by the organism. Such
investigations havebeen performed several times in the majority of
Europeancountries. In a number of them it has been determined that
amountof 10 mg of iodine per 1 kg of salt is insufficient, so thatamount
of iodine has been increased up to 20 mg/kg of salt (i.e.Austria,
Switzerland, former GDR). The present, mostly clinical,knowledge indicates
a probable low iodine intake in some parts ofCroatia, but there is no
reliable estimation of endemic goiter.Based on our research findings we
should be able to concludewhether the regulations of the Croatian law on
mandatoryiodination of all salt for human and animal use need changing,and
should the amount of iodine be increased. So the long-termgoal of the
project is eradication of the endemic goiter as apublic health problem in
the Croatia. One Ph.D thesis (author: Mesaroš-Šimunčić) and two MSc.
thesis (Lacić and Voskresensky-Horvat) are supposed to came out as a
results of proposed investigation.
COOPERATION - PROJECTS
Name of project
: Kontrola jodne profilakse na području
Republike Hrvatske s uvođenjem potrebnih mjera za suzbijanje gušavosti Name of institution: Komisija za suzbijanje gušavosti i kontrolu
jodne profilakse pri Ministarstvu zdravstva Republike Hrvatske City: 10000 - Zagreb, Croatia
COOPERATION - INSTITUTIONS
Name of institution
: The International Council for the Control
of Iodine Deficiency Disorders (ICCIDD) Type of institution: State administration City: Brussels, Belgija Other information about the project.