SVIBOR - Project code: 3-01-224

MINISTRY OF SCIENCE AND TECHNOLOGY

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Project code: 3-01-224


CARDIAC FUNCTION IN ISCHEMIC HEART DISEASE


Main researcher: MIHATOV, ŠIME (97500)



Assistants
Type of research: applied
Duration from: 01/01/91. to 12/31/95.

Papers on project (total): 56
Papers on project quoted in Current Contents: 8
Institution name: Bolnica "Sestre milosrdnice", Zagreb (134)
Communication

Summary: The aim of this research was to assess the influence of the size of myocardial infarction on cardiac function,the efficacy of thrombolytic therapy of acute myocardial infarction and precise evaluation of the cardiac function in patients with myocardial infarction in the acute and chronic phase,using multiparametric approach.

Keywords: myocardial infarction,infarct size,left ventricular function,thrombolytic therapy,exercise testing,diastolic dysfunction

Research goals: The aim of this investigation was to analyze the influence of ischemic heart disease on the cardiac function,how to optimally influence the coarse of the disease with therapy and preservation of cardiac function,as well as precise estimation of cardiac function what is the cornerstone of assessment of work capacity. Investigation was performed in sveral directions: 1.-investigation of the succes of fibrinolytic treatment of acute myocardial infarction,and the assessment of the cardiac function in acute and chronic phase in comparison with other methods, 2.-investigation of electrocardiographic and vectocardiographic signs of previous myocardial infarction and infarction size, 3.-investigation of the relationship between the size of myocardial infarction and diastolic function, 4.-investigatio of global and regional disturbances of the left ventricular function in patients with myocardial infarction, The expected scientific contribution of this investigation is in better understanding of heart pump function during acute and chronic phase of myocardial infarction,and better knowledge of the efficiency of different therapeutic approach. The results of this investigation approve: -precise estimation of exercise tolerance in everyday or professional life,the estimation of working capacity,and the choice of the most optimal rehabilitation treatment -evaluation of therapeutic treatment which are of the most interest in the treatment of ischemic heart disease -rationalisation of diagnostic procedures in the assessment of cardiac function concidering a wide spectrum of cardiologic techniques,with purpose to eliminate expnsive or invasive with more simple and non invasive procedures.

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Last update: 11/04/95
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