- Type of paper
: Book
Title: Acute renal failure
- Editors
- Ljutić, Dragan (132855)
- Rumboldt, Zvonko (36500)
Publisher: Slobodna Dalmacija
Year: 1995
Number of pages: 388
Language: hrvatski
Other: Knjiga je sastavljena od predavanja održanih tijekom
simpozija s temom Akutno zatajenje bubrega, održanog u Splitu 4. i 5.
stidenog 1994. godine.
U sastavljanju članaka sudjelovalo je 64 autora, od kojih su većina bili
predavači na simpoziju.
- Type of paper
: Book
Title: The chosen chapters from pharmacotherapy, 4th edition
- Editors
- Rumboldt, Zvonko (36500)
Publisher: KBC Split, Jedinica za znanstveni rad
Year: 1992
Number of pages: 436
Language: hrvatski
- Type of paper
: Paper in book
Title:
- Authors:
- Rumboldt, Zvonko (36500)
Publisher: Izdavačka kuća "Naprijed"
ISBN: 8634902897
Year: 1991
Pages: from 697 to 709
Number of references: 11
Language: hrvatski
- Type of paper
: Paper in book
Title:
- Authors:
- Ljutić, Dragan (132855)
Publisher: Wichting Editore
ISBN: 8885053920
Year: 1991
Pages: from 163 to 166
Number of references: 5
Language: engleski
Summary: This study investigates whether there are differences in
serumdigitalis-like substance (DLS) response to insulin-inducedhypoglycemia
between normotensime and hypertensive obesesubjects. Nineteen overweight
persons were placed on a ten daytotal starvation. According to blood
pressure measurements beforeand after starvation, examinees were classified
into threegroups: Group I-normotensive before and after,
GroupII-hypertensive before and after, and Group III-hypertensivebefore and
normotensive after the intervention. At the same timebasal DLS, glucose and
insulin level immediately before, as wellas 60 min after insulin bolus
(0,175 U/kg b.w.) were measured;plasma volume was also determined. The were
no differences in ageor body weight between these groups, and in all a
significant(p<0,05) starvation-induced decrease in mean arterial
pressure,glucose, insulin and plasma volume were observed. Beforestarvation
a significant (p<0,05) increase in DLS induced byinsulin-hypoglycemia was
detected in Group I, but not in Group IIand Group III. After starvation
there was a significant increasein DLS in Group I and Group III, but in
Group II this increasewas not significant. These results suggest that in
obesehypertensives there is a blunted rise in insulin-hypoglycemiainduced
DLS serum level.
- Type of paper
: Paper in book
Title:
- Editors
- Rumboldt, Mirjana (111354)
- Rumboldt, Zvonko (36500)
- Pesenti, Serafina (111391)
Publisher: Manuel Judice Halpern
ISBN: 0861963547
Year: 1992
Pages: from 495 to 497
Number of references: 3
Language: engleski
- Type of paper
: Paper in book
Title: Treatment of hypertension
- Authors:
- Bagatin, Jugoslav (61246)
- Editors
- MIRIĆ, DINKO
- Vuković, Ivo
Publisher: Hrvatsko kardiološko društvo-ogranak split
Year: 1994
Pages: from 203 to 212
Number of references: 25
Language: hrvatski
- Type of paper
: Paper in book
Title: Rational antiarrhythmic treatment in 1994
- Authors:
- Rumboldt, Zvonko (36500)
- Editors
- MIRIĆ, DINKO
- Vuković, Ivo
Publisher: Hrvatsko kardiološko društvo-ogranak split
Year: 1994
Pages: from 149 to 156
Number of references: 18
Language: hrvatski
- Type of paper
: Paper in book
Title: Diuretics in acute renal failure
- Authors:
- Bagatin, Jugoslav (61246)
- Editors
- Ljutić, Dragan (132855)
- Rumboldt, Zvonko (36500)
Publisher: Slobodna Dalmacija
Year: 1995
Pages: from 265 to 269
Number of references: 5
Language: hrvatski
- Type of paper
: Paper in book
Title: Arterial hypertension
- Authors:
- Rumboldt, Zvonko (36500)
- Editors
- Vrhovac, Božidar
Publisher: Naprijed
ISBN: 86-349-0288-9
Year: 1991
Pages: from 697 to 712
Language: hrvatski
- Type of paper
: Paper in book
Title:
- Authors:
- Bagatin, Jugoslav (61246)
- Editors
- Rumboldt, Zvonko (36500)
Publisher: KBC Split, Jedinica za znanstveni rad
Year: 1992
Pages: from 70 to 71
- Type of paper
: Paper in book
Title:
- Authors:
- Bagatin, Jugoslav (61246)
- Editors
- Rumboldt, Zvonko (36500)
Publisher: KBC Split, Jedinica za znanstveni rad
Year: 1992
Pages: from 71 to 74
- Type of paper
: Paper in book
Title:
- Authors:
- Bagatin, Jugoslav (61246)
- Editors
- Rumboldt, Zvonko (36500)
Publisher: KBC Split, Jedinica za znanstveni rad
Year: 1992
Pages: from 129 to 131
- Type of paper
: Paper in book
Title:
- Authors:
- Bagatin, Jugoslav (61246)
- Editors
- Rumboldt, Zvonko (36500)
Publisher: KBC Split, Jedinica za znanstveni rad
Year: 1992
Pages: from 283 to 289
- Type of paper
: Paper in book
Title:
- Authors:
- Bagatin, Jugoslav (61246)
- Editors
- Rumboldt, Zvonko (36500)
Publisher: KBC Split, Jedinica za znanstveni rad
Year: 1992
Pages: from 361 to 367
- Type of paper
: Paper in journal
Title: EARLY DETECTION AND FOLLOW-UP OF CARDIOVASCULAR RISK
FACTORS:PECULIARITIES IN SCHOOL CHILDREN
- Authors:
- Rumboldt, Mirjana (111354)
- Rumboldt, Zvonko (36500)
- Pesenti, Serafina (111391)
Journal: Croatian Medical Journal
Number: 2
ISSN: 0353-9504
Volume: 34
Year: 1993
Pages: from 143 to 147
Number of references: 12
Language: engleski
Summary: To evaluate the prevalence, persistence, and impact of
cardiovascular risk factors in school age, 116 children (55 boys and 61 g
irls) was included in a six-year long prospective study (1982-1988).
Systolic and diastolic blood pressure, relative weight,and serum
concentrations of cholesterol and triglycerides were fo
llowed up. Values above the 90th percentile for age and sex were
considered elevated.In the first year, the most prevalent riskfactors were
elevated systolic blood pressure (in 50.9% of the bo
ys and 42.7% of the girls), and high levels of cholesterol (in40.0% of the
boys and 44.3% of the girls). The same factors werestill most prevalent at
the end of the sixth year. In the firststudy year, the majority of
examinees (45.7%) with elevated riskpresented with only one risk factor,
while at the end of thestudy, the majority of the examinees (36.4%) had two
riskfactors. The tracking of risk factors was the highest for increa
sed relative weight (r=0.9) and for elevated cholesterol (r=0.8), and the
lowest for elevated serum triglyceride levels (r=0.1).
It is concluded that understanding and knowledge of risk factors
in childhood may substantially contribute to the prevention
ofcardiovascular disease in adults. Latent or manifest obesity, ele
vated levels of arterial pressure and cholesterol are the mainintervention
targets for the prevention of adult atherosclerosis
in school age.
Keywords: CARDIOVASCULAR DISEASES, RISK FACTORS, SCHOOL MEDICINE
- Type of paper
: Paper in journal
Title: ELECTROCARDIOGRAPHIC PATTERN OF ACUTE MYOCARDIAL
INFARCTION IN PATIENTWITH FAR ADVANCED HYPERKALEMIA
- Authors:
- Polić, Stojan (77340)
- Rumboldt, Zvonko (36500)
- Bagatin, Jugoslav (61246)
Journal: Liječnički Vjesnik
Number: 115
ISSN: 0024-3477
Volume: 115
Year: 1993
Pages: from 40 to 42
Number of references: 14
Language: hrvatski
Summary: We report herein an insulin dependent diabetic with chronic
renal
insufficiency on hemodialysis who developed cardiogenic shock,severe
metabolic acidosis with kalemia of 9 mmol/l during alimen
tary intoxication and who presented with an ECG resembling anacute
myocardial infarction. Possible pathophysiologic factors inthe development
of such electrocardiographic patterns have beenoutlined. It is concluded
that in far advanced hyperkalemia an ab
normal QRS complex, elevated ST segment and no visible P waves sh
ould primarily suggest changes caused by hyperkalemia rather thanmyocardial
infarction.
Keywords: MYOCARDIAL INFARCTION, HYPERKALEMIA, ELECTROCARDIOGRAPHY
- Type of paper
: Paper in journal
Title: DIURETIC EFFICIENCY OF FUROSEMIDE IN CONTINUOUS
INTRAVENOUS INFUSION VS. BOLUS INJECTION IN CONGESTIVE HEART FAILURE:
RESULTS OF A PILOT STUDY
- Authors:
- Bagatin, Jugoslav (61246)
- SARDELIĆ, SANDA (187195)
- Drinovec, JOŽE
- Rumboldt, Zvonko (36500)
- Polić, Stojan (77340)
- MIRIĆ, DINKO
- Pivac, Nediljko (146831)
Journal: Pharmaca
ISSN: 0031-6857
Volume: 31
Year: 1993
Pages: from 279 to 286
Number of references: 21
Language: hrvatski
Summary: In a randomized, single-blind clinical trial diuretic
efficiency
of furosemide administered in either continuous intravenousinfusion or
conventional bolus injection was compared. Includedwere 12 patients of both
sex (5 males and 7 females), aged70.9+(-)6.9 years, with average body
weight 75.0+(-)15.1 kg, all
suffering from congestive heart failure. The patients wererandomly assigned
to two groups. After a two-day period ofobservation, each examinee received
furosemide b.i.d. 40 mgeither as an intravenous injection (Group A) or as
an 1-hourinfusion (Group B), these shedule being reversed the next day.All
patients were additionally treated with digoxin in an average
dose of 0.25 mg. Although the furosemide infusion resulted ingreater
proportional increase in urine output (in comparison withbaseline), there
were no significant differences between the twoways of administration,
regardless of the order of application.It is concluded in the management of
refractory oedema inpatients with congestive heart failure, continuous
intravenousinfusion of furosemide is marginally more effective than
iv.bolus. Large doses and the longer infusion times are presumblyrequired
for more pronounced diuresis.
Keywords: FUROSEMIDE, CONGESTIVE HEART FAILURE, INTRAVENOUS INJECTION, DIURESIS
- Type of paper
: Paper in journal
Title: OUTPATIENT APPROACH TO ARTERIAL HYPERTENSION:AN ANALYSIS
OF THE THREE-YEAR WORK OF THE OUTPATIENT DEPARTMENT, UNIVERSITY HOSPITAL
SPLIT
- Authors:
- Bagatin, Jugoslav (61246)
- SARDELIĆ, SANDA (187195)
- Rumboldt, Zvonko (36500)
- KORLJAN-BABIĆ, BETTY
- Naranča, Mario (193596)
- Pivac, Nediljko (146831)
- Šimunić, Miroslav (146175)
Journal: Liječnički Vjesnik
ISSN: 0024-3477
Volume: 115
Year: 1993
Pages: from 30 to 34
Number of references: 30
Language: hrvatski
Summary: A retrospective analysis of 5 088 hypertensives treated by
ourOutpatient Clinic, Department of medicine, University HospitalSplit from
1988 through 1990 is presented. Male sex waspredominant (about 65%) and
almost all the patients (over 95%)were overweight and the majority (over
50%) have had mild hyper
tension. Essential form was by far the most prevalent type of hy
pertension (over 95%), while curable forms of secondaryhypertension were
rare indeed (less than 0.2%). Diuretics and be
ta blockers, the traditional first-line antihypertensives werethe most
prescribed drugs (over 60%), while the share of ACE inh
ibitors, calcium antagonists, and alpha blockers was steadily in
creasing. General measures, such as body weight reduction, salt
restriction or cessation of smoking although obligatory part of
the treatment and suggested to each hypertensive, are rarely car
ried out.
Keywords: HYPERTENSION, AMBULATORY CARE
- Type of paper
: Paper in journal
Title: CONTROLLED MULTICENTRE COMPARISON OF CAPTOPRIL VERSUS
LISINOPRIL IN THE TREATMENT OF MILD-TO-MODERATE ARTERIAL HYPERTENSION
- Authors:
- Rumboldt, Zvonko (36500)
- Šimunić, Miroslav (146175)
- Bagatin, Jugoslav (61246)
- Rumboldt, Mirjana (111354)
- Marinković, M
- Janežić, A
Journal: International Journal of Clinical Pharmacology Research
Number: 1
ISSN: 0251-1649
Volume: 13
Year: 1993
Pages: from 35 to 41
Number of references: 23
Language: engleski
Summary: The antihypertensive efficacy and safety of lisinopril (L),
anovel ACE inhibitor, were compared to those of captopril (C), thefamiliar
drug of the same class, in a multicentre controlledtrial. The study
included 91 mild-to-moderate, middle-aged hyper
tensives of both genders, 46 of which were randomized to C and 45to L.
After a two-week placebo period the examinees werereceiving either L o.d.
in increasing dosage of 10, 20, or 40 mgper day (amount necessary to
achieve normotension), or C b.i.d.in a corresponding daily dose of 25, 50,
or 100 mg. During theeight-week formal part of the trial, L decreased
systlic bloodpressure from the initial values by an average of 14.9%, an
the
diastolic pressure by some 15.2%. The same parameters werelowered on C by
11.2%,and 11.7%, respectively. The mean arterialpressure from an initial
average of 125.5 mm Hg was lowered to110.9 mm Hg on C (11.6% reduction,
p<0.01), and from 125.3 mm Hgto 108.2 mm Hg on L (13.6% reduction, p<0.01).
Although the Leffects were more pronounced, the observed
between-groupdifferences did not reach the level of statistical
significance,except for the achievement of normotension, which disclosed
thesuperiority of L (p<0.05). The tolerability of both drugs wasgood and
only one examinee had to be excluded because ofside-effects (proteinuria).
It is concluded that both ACEIs understudy showed comparable efficacy and
safety, L being marginallymore potent and longer acting.
- Type of paper
: Paper in journal
Title: HOW MUCH ...
- Authors:
- Rumboldt, Zvonko (36500)
- Bagatin, Jugoslav (61246)
- SARDELIĆ, SANDA (187195)
Journal: Acta Fac Med Flum
ISSN: 0065-1206
Volume: 47
Year: 1993
Pages: from 51 to 52
Language: hrvatski
- Type of paper
: Paper in journal
Title: SHOULD ...
- Authors:
- Ljutić, Dragan (132855)
- Rumboldt, Zvonko (36500)
Journal: Renal Failure
Number: 1
ISSN: 0886-022
Volume: 15
Year: 1993
Pages: from 73 to 76
Number of references: 14
Language: engleski
Summary: To assess the hypokalemic effect of intravenous glucose (25
gi.v. in 5 min) followed by regular insulin (10 U) bolus, as wellas the
incidence of hypoglycemia, a well-known side effect ofthis intervention,
nine uremic patients on maintenancehemodialysis were studied. Measurements
were done of plasmapotassium, glucose, insulin, and C-peptide before, and
15, 30, 45and 60 min after glucose and insulin. The intervention induced
asignificant fall in plasma potassium level, a significant riseand then
fall in plasma glucose, and a significant increase inthe insulin and
C-peptide levels. These data suggest thathypertonic glucose infusion should
procede, not follow, theinsulin bolus in the management of hypokalemia.
Such an approachis clinically effective and well tolerated, with no
hypoglycemicside effects.
- Type of paper
: Paper in journal
Title: Q-T ...
- Authors:
- Ljutić, Dragan (132855)
- Rumboldt, Zvonko (36500)
- Šimunić, Miroslav (146175)
- Pivac, Nediljko (146831)
- Bagatin, Jugoslav (61246)
- Andrews, Peter
- Andrews, Peter
Journal: International Journal of Cardiology
ISSN: 0167-5273
Volume: 42
Year: 1993
Pages: from 161 to 164
Number of references: 10
Language: engleski
Summary: To assess whether measurement of the electrocardiographic
(ECG)Q-T interval is a useful predictor of total serum
calciumconcentration, 15 uraemic patients were studied (10 female, 5 ma
le;age range,25-60 years). resting ECGs were interpreted by three
independent observers without knowledge of the patients identityor serum
calcium. Three variants of measurement of the Q-Tinterval were analysed, of
which Qa-Tc, the interval from thebeggining of the Q-wave to the apex of
the T-wave, was the mostconsistent (coefficient of variation, 2.7%). This
also providedthe best correlation with measured serum calcium concentration
p<0.001. When compared by biochemical measurements, thepredictive serum
calcium concentration was within 95% confidencelimits in 14 of the 15
patients studied. However, the wideconfidence limits of this technique mean
that it can not berecommended in rutine clinical practice.
Keywords: BAZETT S FORMULA, SERUM CALCIUM, Q-T INTERVAL
- Type of paper
: Paper in journal
Title: INSULIN AND ARTERIAL BLOOD PRESSURE
- Authors:
- Ljutić, Dragan (132855)
Journal: Medicina
ISSN: 0025-7729
Volume: 28
Year: 1992
Pages: from 107 to 110
Number of references: 41
Language: hrvatski
Summary: Many studies point out the possible role of insulin not
only inthe pathogenesis of obesity hypertension, but also in the patho
genesis of essential hypertension. Namely, a significantrelationship
between the serum insulin levels and the bloodpressure values in
hypertensives (nonobese and obese) wasestablished. The pathogenetic steps
of the arterial hypertension(the essential one and the one in obese
patients) could be set upin mosaic having in its centre an acquired or
genetic insulinresistance with consecutive hyperinsulinemia, and all the
insulineffects on cardiovascular system (inotropic action
andvasodilatation), on the sympatic nervous system(stimulation-inotropic
effect, vasoconstriction, sodiumretention), on the kidneys (sodium
retention), and on endoxinexcretion (stimulatuion-natriuresis and
vasoconstriction).
Keywords: INSULIN, ARTERIAL BLOOD PRESSURE
- Type of paper
: Paper in journal
Title: WHAT S OUR INSIGHT IN THE MANAGEMENT OF CARDIAC
ARRHYTHMIAS?
- Authors:
- SARDELIĆ, SANDA (187195)
- Rumboldt, Zvonko (36500)
- Šimunić, Miroslav (146175)
- Naranča, Mario (193596)
- Pivac, Nediljko (146831)
- KORLJAN-BABIĆ, BETTY
Journal: Liječnički Vjesnik
Number: 5
ISSN: 0024-3477
Volume: 115
Year: 1993
Pages: from 156 to 159
Number of references: 11
Language: hrvatski
Summary: By an anonymous, multiple-choice questionnaire assessed was
theknowledge of cardiac electrophysiology and mechanism of action ofsome
antiarrhythmic drugs among the staff members of a departmentof medicine
from a large regional hospital. The overall resultswere disappointing (over
55 per cent of inaccurate answers), butimproved after 3 months (less than
30 per cent). It is concludedthat such a polling increases the level of
awereness about targetproblem (cardiac arrhythmia management in the actual
case) andimproves the performance of health professionals.
Keywords: ARRHYTHMIA, ANTI-ARRHYTHMIC AGENTS, EDUCATIONAL MEASUREMENT
- Type of paper
: Paper in journal
Title:
- Authors:
- Rumboldt, Mirjana (111354)
- Rumboldt, Zvonko (36500)
Journal: Medicinski Anali
Number: 2311
ISSN: 0352-602
Volume: 18
Year: 1992
Pages: from 311 to 314
Number of references: 13
Language: hrvatski
- Type of paper
: Paper in journal
Title: A CONTROLLED COMPARISON OF NICARDIPINE VS. PROPRANOLOL IN
THE TREATMENT OF ARTERIAL HYPERTENSION
- Authors:
- Kuzmanić, Ante (121695)
- Rumboldt, Zvonko (36500)
- Naranča, Mario (193596)
- Bagatin, Jugoslav (61246)
- Rakić, Drago (121684)
- MIRIĆ, DINKO
- Naranča, Mario (193596)
- Obad, Marko
Journal: Liječnički Vjesnik
ISSN: 0024-3477
Volume: 113
Year: 1991
Pages: from 37 to 41
Number of references: 13
Language: hrvatski
Summary: A randomized collective comparative study between
nicardipine (N)and propranolol (P) was conducted over a period of 7 weeks
inthirty hypertensive patients of both sexes, aged from 20 to 65years, with
the diastolic pressure over 100, bu below 120 mm Hg.
Thirteen examinees were given N (60-120 mg daily) and seventeen P
(120-240mg daily); the groups were comparable according to a seri
es of relevant parameters. In the placebo-period the meanarterial pressure
(MAP) was slightly lowered, by 4.4% (p>0.20).MAP was, however, considerably
lowered already at the end of thesecond week of active treatment both in
the N group (from135.1+(-)7.4 to 116+(-)10.8 mm Hg, or by 19.1%;p<0.01), as
wellas in the P group (from 131.6+(-)8.1 to 117+(-)9.1 mm Hg, by anaverage
of 11.1%;p<0.05). The values continued to decrease, andat the end of the
seventh week of the study MAP averaged108.5+(-)6.5 mm Hg (-19-7%;p<0.01) in
the N group, while it was109.7+(-)9.1 mm Hg (-16.6%;p<0.01) in the P group.
The heart ratebecame considerably slower in the P group only, from
initial84.5+(-)9.2 to 66.9+(-)2.7 beats per minute at the end of theseventh
week (-20.8%;p<0.01), but it was unexpectedly, althoughnot significantly
lowered also in the N group, from the initial78.3+(-)6.5 to 74.2+(-)4.0
beats (-5.2%;p>0.20). Otherdifferences did not reach the level of
statistical significance.The laboratory findings did not differ between the
groups and didnot vary significantly during the study. Two examinees
withdrewfrom the study owing to side-effects (headache,
palpitations,flushes). The conclusion is that nicardipine and propranolol
areantihypertensives of comparative efficiency, the former being
more efficient, while the latter was better tolerated inmonotherapy.
Keywords: HYPERTENSION, NICARDIPINE, PROPRANOLOL, CLINICAL TRIALS
- Type of paper
: Paper in journal
Title: THE EFFECT OF WEIGHT REDUCTION ON BLOOD PRESSURE AND
ERYTHROCYTE MEMBRANE SODIUM/POTASSIUM FLUX IN OBESE SUBJECTS
- Authors:
- Ljutić, Dragan (132855)
- Rumboldt, Zvonko (36500)
- KORŠIĆ, Mirko
- TEPAVČEVIĆ, DANILO
Journal: Medicinski Anali
Number: 1
ISSN: 0352-602
Volume: 17
Year: 1991
Pages: from 19 to 24
Number of references: 19
Language: hrvatski
Summary: The effect of weight reduction induced by ten-day
totalstarvation on blood pressure and erythrocyte membranesodium/potassium
flux in 19 obese subjects (16 women and 3 men,18-50 years of age) with body
mass index above 27 kg/m2, werestudied. Six were normotensive and 13
hypertensive. Significantfall in systolic, diastolic,and mean blood
pressure inhypertensive, and in systolic blood pressure in
normotensivesubjects only, were noted. Significant changes in
sodium/potassium flux either in normotensive or hypertensive examinees
werenot noted. Presented results show that the beneficial effect ofweight
reduction on blood pressure does not depend on changes ofmembrane
sodium/potassium flux.
Keywords: OBESITY, ARTERIAL HYPERTENSION, ERYTHROCYTE MEMBRANE SODIUM/POTASSIUM FLUX, STARVATION, WEIGHT REDUCTION
- Type of paper
: Paper in journal
Title: COMPARISON ...
- Authors:
- Šimunić, Miroslav (146175)
- Rumboldt, Zvonko (36500)
- GILJANOVIĆ, M
- RUMBOLDT, ZORAN
Journal: Croatian Medical Journal
ISSN: 0353-9504
Volume: 33
Year: 1992
Pages: from 23 to 28
Number of references: 10
Language: engleski
Summary: In a multicenter double-blind clinical trial, the efficacy
andacceptability of enalapril (20 mg daily) and of a fixedcombination of
enalapril-hydrochlorothiazide (10 mg + 25 mg) werecompared. After a
two-week placebo period, 100 essentialhypertensives of both sexes (mean age
48 +/- 9, mean bloodpressure 175.0 +/- 18.1/110.2 +/- 8.6 mm Hg) were
randomlyallocated to either enalapril monotherapy for 4 weeks, followedby 4
weeks of the combination (group A, 52 patients) or thereverse order of
medication (group B, 48 patients). After thefirst two weeks of active
treatment, the systolic and diastolicblood pressure in supine position
decreased by 9,9% and 8,9%,respectively, in the monotherapy group. In the
combined therapygroup, the same parameters decreased by 12,9% and
13,5%respectively (p<0,05 ,both within- and between-group). A similartrend
persisted up to the end of the fourth week. Aftercross-over, the
combination further decreased the blood pressurelevels achieved, while
monotherapy more or less maintained thesame values: in group A, the final
blood pressure in supineposition was 144,5 +/- 17,7/89,4 +/- 9,2 (an
18,4%/18,8%reduction as compared to the initial values); in group B,
147,7+/- 18,1/91,1 +/- 7,6 (a 14,2%/17,4% reduction of the initialvalues).
The drugs under study were well tolerated, and onlytrivial side-effects
were recorded. Thus, a fixed combination ofa low dose of enalapril (10 mg)
and hydrochlorothiazide (25 mg)was concluded to be marginally superior in
terms of effectivenessto a higher dose (20 mg) of enalapril in monotherapy,
anddefinitely less expensive.
Keywords: Drug therapy - combination; enalapril; Hydrochlorothiazide; hypertension.
- Type of paper
: Paper in journal
Title: IPERTENSIONE...
- Authors:
- Rumboldt, Zvonko (36500)
Journal: Acta Medica Croatica
ISSN: 1330-0164
Volume: 20
Year: 1990
Pages: from 421 to 424
Number of references: 9
Language: talijanski
- Type of paper
: Paper in journal
Title: A COMPARATIVE TRIAL BETWEEN CAPTOPRIL AND LISINOPRIL IN
PATIENTS WITH MILD AND MODERATE ARTERIAL HYPERTENSION
- Authors:
- Rumboldt, Zvonko (36500)
- Janežić, A
- KNEŽEVIĆ, SVETOZAR
- Marinković, M
- Šimunić, Miroslav (146175)
- LIJIĆ, JASMINKA
Journal: Liječnički Vjesnik
ISSN: 0024-3477
Volume: 113
Year: 1991
Pages: from 89 to 92
Number of references: 13
Language: hrvatski
Summary: The antihypertensive efficc
n mh
vbnnbnbbgbbbv
The antihypertensive efficacy and safety of lisinopril (L), anovel ACE
inhibitor, was compared to captopril (C), the known andalready approved
drug in our country in a multicenterdouble-blind Yugoslav trial. The study
included 91mild-to-moderate hypertensive patients of both sexes.
Forty-sixpatients were randomized to receive captopril and 45
lisinopril.After a 2 week placebo, the examinees were administered either
Lin increasing dose of 10, 20 or 40 mg per day (amount necessaryto achieve
normotension), or C in a dosage of 25, 50, or 100 mgper day. During the 8
week formal trial L decreased the systolicblood pressure by an average of
14,9% from the initial values,and the diastolic pressure by some 15,2%. The
same parameterswere lowered on C by 11,2%, and 11,7% respectively. Although
theL effects were more pronounced, the observed differences did notreach
the level of statistical significance (except for thedose-to-normotension
relationship which was significantly betterin the L group). It is concluded
that both ACEIs under studyshowed comparabile efficacy and tolerability, L
being marginallymore potent, and longer acting.
Keywords: Captopril, Enalaprilat, Hypertension
- Type of paper
: Paper in journal
Title: COMPARISON OF ENALAPRIL AND ITS COMBINATION WITH
HYDROCHLOROTHIAZIDE IN THE MENAGEMENT OF MILD-TO-MODERATE HYPERTENSION
- Authors:
- Rumboldt, Zvonko (36500)
- Šimunić, Miroslav (146175)
- DRINOVEC, JOŽE
- Kocijančić, Maksimilijan
- Benc, Dragan
- Zdravković, Mihail
- SARDELIĆ, SANDA (187195)
- Lijić, Jasminka
- Naranča, Mario (193596)
Journal: Medicina
ISSN: 0025-7729
Volume: 27
Year: 1991
Pages: from 145 to 149
Number of references: 13
Language: hrvatski
Summary: In a multicentrem double-blind Yugoslav clinical trial
theantihypertensive efficacy and acceptability
ofenalapril-hydrochlorothiazide (10 mg + 25 mg) combination tothose of
enalapril monotherapy (20 mg daily was studied. After atwo-weeks placebo
period, 100 essential hypertensives of bothsexes, 48 +/- 9 years old with
an overage blood pressure of175,0/110,2 +/- 18,1/8,6 mm Hg, were randomized
either toenalapril monotherapy (20 mg daily) for 4 weeks, followed,without
break, by 4 weeks of combination (10 mg of enalapril + 25mg of
hydrochlorothiazide) (group A, 52 examinees), or to thereverse order of
medication (group B, 48 examinees). After thefirst two weeks of active
treatment, the systolic blood pressuredecreased by 9,9%, and the diastolic
one by 5,7% in themonotherapy group . The same parameters were decreased by
12,7%and 11,3%, reapectively, in the combined therapy group, which
isstatistically significant. Similar result were obtained after thefourth
week of the treatment after reversing the order ofmedication, the
combination of enalapril and hydrochlorothiazidecontinued decreasing mildly
the registered blood pressure of theexaminees previously treated only with
enalapril. While themonotherapy more of less maintained the values achieved
bycombination. In the group A the final blood pressure was144,5/89,4 +/-
17,7/9,2 (19,1% reduction comparing with theinitial values), and in the
group B 146,6/91,0 +/- 18,6/6,5(17,3% reduction comparing with the initial
values). The effectof combination of enalapril in a lower dosage (10 mg)
withhydrochlorothiazide (25 mg) is marginally superior in terms
ofeffectiveness to higher dose (20 mg) of enalapril in monotherapy.During
the tral the drugs were well tolerated, and onlynonspecific side-effects
were registered, not requiring theinterruption of the treatment.
Keywords: ARTERIAL HYPERTENSION, ACE INHIBITORS, DIURETICS, ENALAPRIL, HYDROCHLOROTHIAZIDE
- Type of paper
: Paper in journal
Title: UN ...
- Authors:
- Rumboldt, Zvonko (36500)
Journal: Le Basi Razionali della Terapia
Volume: 21
Year: 1991
Pages: from 371 to 379
Number of references: 25
Language: talijanski
- Type of paper
: Paper in journal
Title: The effect of insulin-induced hypoglycemia on endoxin
serum level in normotensives and in borderline hypertensives
- Authors:
- Ljutić, Dragan (132855)
- TEPAVČEVIĆ, DANILO
- KORŠIĆ, Mirko
- Halimi, Setar
Journal: Acta Fac med Flum
Number: 1
ISSN: 0065-1206
Volume: 18
Year: 1993
Pages: from 33 to 37
Number of references: 25
Language: hrvatski
Keywords: ENDOXIN, INSULIN, HYPOGLYCEMIA, HYPERTENSION, STRESS
- Type of paper
: Paper in journal
Title: Our approach to orthostatic hypotension
- Authors:
- Bagatin, Jugoslav (61246)
- Rumboldt, Zvonko (36500)
- SARDELIĆ, SANDA (187195)
- Polić, Stojan (77340)
- MIRIĆ, DINKO
Journal: Clinical Autonomic Research
Volume: 3
Year: 1993
Pages: from 219 to 220
Language: engleski
- Type of paper
: Paper in journal
Title: A comparison of amlodipine vs. sustained-release
nifedipine in essential hypertension
- Authors:
- Pivac, Nediljko (146831)
- Dobovišek, Jurij
- Bagatin, Jugoslav (61246)
- Gros-Furek, Veronika
- Rumboldt, Zvonko (36500)
- Kveder, Rado
- Janežić, A
- Sjerobabski, Vladimir
- Šimunić, Miroslav (146175)
- SARDELIĆ, SANDA (187195)
Journal: Liječnički Vjesnik
ISSN: 0024-3477
Volume: 115
Year: 1993
Pages: from 356 to 359
Number of references: 19
Language: hrvatski
Summary: The efficacy and acceptability of amlodipine (5-10 mg o.d.)
and sustained release nifedipine (20-40 mg b.i.d.) were compared in a
multicentre double-blind clinical trial. After a two-week placebo period,
71 essential hypertensives of both sexes, age 51.7+/-8.5 years, having
diastolic blood pressure of 95-114 mm Hg were randomly alocated to either
amlodipine 5 mg once daily (group A) or nifedipine 20 mg twice daily (group
B). With respect to the blood pressure response the initial dose was
doubled after 2 weeks. No significant differences in blood pressures
recorded at baseline and at the end of the placebo period were
demonstrated. A significant reduction in both systolic and diastolic blood
pressures in the supine was observed already 2 days after the start of
treatment. In the group A it decreased from 163.2+/-21.4 / 102.7+/-8.5 to
155.7+/-20.7 / 98.2+/-8.9 mm Hg (p<0.05) and in the group B from
160.5+/-16.2 / 100.5+/-12.2 to 152.2+/17.0 / 95.4+/-9.5 mm Hg (p<0.05). The
similar changes of blood pressure were observed in the standing position,
as well. At the end of the study, the overall reduction of the supine
diastolic blood pressure was 12.5% in the group A vs. 5.2% in the group B
(p<0.05). In the standing position amlodipine decreased diastolic blood
pressure by 8.8% and nifedipine by 6.4% (p<0.05). Furthermore, amlodipine
decreased the standing blood pressure to a greater extent (8.8% vs.
6.4%;p<0.05) than nifedipine. A 24-hour maintenance of the achieved goal
blood pressure was confirmed in 8 patients from each group, using a
continued ambulatory monitoring. An increase in heart rate for 4.1% (A) and
5.2% (B), which did not last until the end of the study. Common side
effects (peripheral oedema, headache, palpitations, nausea) were recorded,
and their incidence was equal in both groups, but more severe in the group
treated with nifedipine. We conclude that between the studied calcium
channel blockers, amlodipine is marginally superior to nifedipine in the
treatment of mild to moderate hypertension.
Keywords: hypertension, nifedipine, calcium channel blockers, antihypertensive agents
- Type of paper
: Paper in journal
Title: Drug utilization analysis in medical and surgical patients
- Authors:
- SARDELIĆ, SANDA (187195)
- Gančević, Ivana
- Bagatin, Jugoslav (61246)
- Rumboldt, Zvonko (36500)
- Pivac, Nediljko (146831)
Journal: Pharmaca
ISSN: 0031-6857
Volume: 32
Year: 1994
Pages: from 43 to 56
Number of references: 25
Language: hrvatski
Summary: Drug utilization profile at the Departments of Medicine and
of Surgery in a large regional hospital was analizyed and compared with the
results of previous similar surveys. In April 1992, 123 charts of internal
and 164 of surgical patients were analyzed. The results are presented in
percentages and defined daily doses. The mean number of drugs prescribed
per patient was 3.41+/-2.04 in the medical, and 4.01+/-3.31 in the surgical
ward (t=1.89,p>0.05). The leading drugs in surgical patients were
antimicrobials (27.3%), followed by blood preparations and substitutes
(24.65%) and drugs acting on the nervous system, mostly analgesics (15.9%).
The actual profile is not unexpected since the majority of admissions were
due to war wounds (in 1991 and 1992 the region of Split was directly
included in the war operations). At the Department of Medicine the leading
position was held by cardiovascular drugs (20.0%), the second by urogenital
agents, mostly diuretics (15.0%), and third by gastrointestinal drugs
(11.9%). The profile was similar to that from 1988, but quantitatively
lower (3.41+/-2.04 vs. 4.0+/-2.8;t=2.09, p<0.05). At the Department of
Surgery the mean drug utilization was significantly higher than in 1988
(4.01+/-3.31 vs. 2.06+/-1.43;t=6.72,p<0.05), which could be explained by
the war situation. The decrease in the use of some drugs and better quality
of the drug utilization profile point to a positive influence of
educational efforts in the field of rational pharmacotherapy, and to a
favourable trend in the hospital drug utilization, which, however was not
immune to the radically altered war circumstances.
Keywords: drug utilzation, pharmacotherapy
- Type of paper
: Paper in journal
Title: ORTHOSTATIC HYPOTENSION Case report of Bradbury-Eggleston
Syndrome
- Authors:
- Bagatin, Jugoslav (61246)
- SARDELIĆ, SANDA (187195)
- Rumboldt, Zvonko (36500)
- Pivac, Nediljko (146831)
- Šimunić, Miroslav (146175)
- Polić, Stojan (77340)
Journal: Liječnički Vjesnik
ISSN: 0024-3477
Volume: 115
Year: 1993
Pages: from 299 to 302
Number of references: 24
Language: hrvatski
Summary: A case of 71-year-old women with idiopathic orthostatic
hypotension is presented. several diagnostic procedures which can detect
sympathetic pathway lesion are reported. The value of blood pressure
measurement and heart rate response to the supine and standing position,
deep breath, Valsalva maneouver, and cold pressor test in differential
diagnosi are emphasized. the venoconstriction, venous reflexes and tyramine
tests are described, as well. The authors favour an individual therapeutic
approach with no limitation of mineralocorticoid dosage. Nonphramacological
measures, such as increased salt intake, elastic support stockings and
swimming are highly recommended.
- Type of paper
: Paper in journal
Title: Ramipril decreases chlorthalidone-induced loss of
magnesium in hypertensives
- Authors:
- Šimunić, Miroslav (146175)
- Rumboldt, Zvonko (36500)
- SARDELIĆ, SANDA (187195)
- Ljutić, Dragan (132855)
- Maras-Šimunić, Marina
- Čapkun, Vesna
- Zekan, Ljubica
Journal: Pharmaca
ISSN: 0031-6857
Volume: 32
Year: 1994
Pages: from 307 to 324
Number of references: 30
Language: hrvatski
Summary: In a double-blind trial, the antihypertensive efficacy and
electrolyte changes in patients treated with a ramipril-chlorthalidone
combination (5mg + 25 mg) were compared to those of chlorthalidone
monotherapy (25 mg daily). After a four-week placebo period, 32 essential
hypertensives of both sexes, aged 51+/-9 years, with mean blood pressure of
181.4/105.5 +/- 13.0/6.9 mm Hg (24.3/13.9 +/- 1.7/0.9 kPa), were randomized
either to the combination (group A, 17 subjects) or to monotherapy (group
B, 15 subjects). After twelve weeks of active treatment, the systolic blood
pressure decreased by 16.1%, and the diastolic one by 13% in the combined
therapy group. The same parameters were decreased by 12.7% and 9.8%
respectively, in the monotherapy group; the observed differences became
statistically significant at the end of 6th week, in favour of combination,
and kept significant until the end of the trial. A similar increament in
24-hour urinary sodium excretion was observed in both groups, with no
significant differences between them. Serum calcium levels increased
slightly in both groups, but there was a significant fall in the 24-hour
urinary calcium excretion, probably due to chlorthalidone, and without
difference between the groups.
The serum potassium level increased slightly in group A (from 4.16+/-0.39
to 4.30+/-0.42 mmol/l (p=0.23), and slightly decreased in group B (from
4.18+/-0.32 to 3.99+/-0.49 mmol/l, p =0.34). In group A, there was no
significant chamge in the urinary potassium excretion, whereas in group B
it increased by approximately 15% (p=0.10). There was a decrease in the
24-hour urinary magnesium excretion in group A (from 4.01+/-1.24 to
3.5+/-0.93 mmol/24 hours, p = 0.16), and an increase in group B (from
3.49+/-0.98 to 4.35+/-1.12 mmol/24 hours, p = 0.05). At the end of the
trial, these changes also became significant between the study groups
(p=0.047). The antihypertensive effect of the combination was faster and
stronger than that of monotherapy. Along with the previously known
supression of the thiazide metabolic side effects, ACE-inhibitors also
appear to decrease the chlorthalidone-induced magnesium excretion. The
possible mechanisms of this ACE-inhibitors effects are: prevention of
secondary hyperaldosteronism, a decrease in sympathetic tone, and a
decrease in glomerular filtration rate due to their effect on glomerular
efferent arteriol.
Keywords: ramipril. chlorthalidone, magnesiuria, arterial hypertension
- Type of paper
: Paper in journal
Title: Vasodilatory effect of chlorthalidone in mild
hypertensives evaluated by occlusive venous plethysmography
- Authors:
- Bagatin, Jugoslav (61246)
- SARDELIĆ, SANDA (187195)
- Rumboldt, Zvonko (36500)
- Pavličević, Ivančica
- Pivac, Nediljko (146831)
- Naranča, Mario (193596)
Journal: Liječnički Vjesnik
ISSN: 0024-3477
Volume: 117
Year: 1995
Pages: from 15 to 18
Number of references: 24
Language: hrvatski
Summary: Thirty hypertensive outpatients of both sexes having
diastolic blood pressure below 110 mm Hg were included in a randomized
trial. Their mean age was 50.4+/-8.6 years. After a two-week placebo
period, the patients were treated with chlorthalidone in a single daily
dose of 25 or 12.5 mg over the one-month period, and the next month the
alternative dose (i.e. 12.5 or 25 mg) was adminstered. Changes in vascular
reactivity were measured by occlusive plethysmography (mercury
starin-gauge) at the end of the placebo period, and then post the first and
second month of therapy. All the observed parameters, i.e. rest flow (RF),
peak flow (PF), venous capacity (VC), and maximal venous outflow (MVO)
increased with 25 mg of chlorthalidone, and similar findings were
registered when a dose of 12.5 mg was given. There was a significant
increase in venous capacity of both groups (from 2.6 to 3.2 and form 3.0 to
3.4 ml/100ml/min) and in peak flow of the group that was on 25 mg of
chlorthalidone as the first dose (from 18.6 to 23.9 ml/100ml/min). Both
doses had similar antihypertensive effect. It is concluded that
antihypertensive effect of chlorthalidone is partly due to chnages in
vascular reactivity in the sense of vasodilation which is more prominent at
the venous side pf the blood flow. Low-dosed chlorthalidone is equipotent
in antihypertensive efficiency, its side effects are rare, and the cost of
therapy is by far the lowest.
Keywords: chlorthalidone, hypertension, plethysmography
- Type of paper
: Paper in journal
Title: An approach to a symptomatic hypotensive patient.
Orthostatic test as a guide to diagnostic and therapeutic procedure
Journal: Pharmaca
Number: 1-2
ISSN: 0031-6857
Volume: 33
Year: 1995
Pages: from 77 to 86
Number of references: 22
Language: hrvatski
- Type of paper
: Paper in journal
Title:
- Authors:
- Raos, Vjekoslava
- Jeren-Strujić, Branka
- Ljutić, Dragan (132855)
- Horvatin-Godler, Srnka
- Štraus, Božidar
Journal: Acta Medica Croatica
ISSN: 1330-0164
Volume: 49
Year: 1995
Pages: from 5 to 14
Number of references: 31
Language: engleski
Summary: The authors investigated the influence of
glyceryl-trinitrate (NTg) given intravenously to the reduction of
infarction size in 95 patients (71 men and 24 women) aged 36-75 years, with
acute myocardila infarction (AIM) admitted to the intensive care unit
within six hours of the onset of pain. Infarction mass was calculated by
mathematical model from the serial changes of CK and CK MB serum activities
during 72 hours and expressed in CK an CK MB gEq. CK and CK MB were
determinated every four hours. The patients were divided into four groups
according to the therapy they were receiving:I : NTG iv (n=29); II SK + NTG
iv (n=29);III SK iv (n=17) and IV ISDN per os (n=20). Each group was
divided into subgroups regarding the time interval from the onset of pain
to the beginning of the therapy (within three hours and after three hours).
Application of NTG iv in the early phase of AIM, 0-3 hours from the onset
of pain, led to the significant reduction of infarction mass CK and CK MB
gEq (0-3 hours; middle rank = 11.35; 3-6 hours: middle rank = 17.7)
(p<0.05) and 0-3 hours: middle rank =10.31; 3-6 hours: middle rank = 18.81
(p<0.01). It was established that the "timing" factor was very important in
the preservation of myocardial mass in AIM. It affirms the efficacy of NTG
iv, i.e. its direct effects on the coronary arteries and systemic effects
that cause salvation of the myocardium. The influence of NTG iv to
myocardial infarction size CK gEq did not depend on ECG localization. But
it influenced the ECG localization when the infarction size was calculated
from CK MB isoenzyme and expressed in CK MB gEq. Infarction mass CK MB gEq
was statistically significantly smaller in the inferior than in the
anterior localization (p<0.05).
Keywords: nytroglycerin therapy, acute myocardial infarction, infarction size
- Type of paper
: Paper in journal
Title: Case report: Successful treatment of Wegener
Granulomatosis by classical "Fauci Protocol"
- Authors:
- Ljutić, Dragan (132855)
Journal: Dialyse-Journal
ISSN: 1330-4488
Volume: 2
Year: 1995
Pages: from 2 to 5
Number of references: 14
Language: hrvatski
- Type of paper
: Paper in journal
Title: Obesity hypertension - an etiopathogenic view
- Authors:
- Ljutić, Dragan (132855)
- KORŠIĆ, Mirko
Journal: Liječnički Vjesnik
ISSN: 0024-3477
Volume: 115
Year: 1993
Pages: from 119 to 122
Number of references: 86
Language: hrvatski
Summary: Many epidemiological and clinical studies show a strong
association between arterial hypertension and obesity. The underlying
pathophysiological mechanism is unknown. It is thought thtat the
etiopathogenesis of obesity hypertension is exceptional and in that view
hormona, neural, volume and hemodynamic properties of obesity, as well as
salt and/or caloric consumption are outlined. In this article all these
factors are discussed. According to the current hypothesis,
hyperinsulinemia which is probably a physiological adaptation to obesity
plays a key role in the pathogenesis of arterial hypertension. Insulin
increases the reabsorption of sodium by means of an immediate effect on the
kidney tubules. An increase of sodium in the body leads to hypervolemia
and to the elevated blood pressure. Chronic hyperinsulinemia perheps
increases the blood pressure indirectly also by means of the central
nervous system, namely, by stimulating the activity of the sympathicus.
Keywords: hypertension, etiology, obesity
- Type of paper
: Paper in proceedings
Title: BIOCHEMICAL ...
- Authors:
- Bagatin, Jugoslav (61246)
- Rumboldt, Zvonko (36500)
- SARDELIĆ, SANDA (187195)
- Polić, Stojan (77340)
- Pivac, Nediljko (146831)
- Šimunić, Miroslav (146175)
- Naranča, Mario (193596)
Proceedings title: PHARMACOLOGICAL COMMUNICATIONS
Language: engleski
Place: Zagreb
Year: 1993
Pages: from 95 to 97
Meeting: First Croatian Congress of Pharmacology
Held: from 10/06/93 to 10/08/93
- Type of paper
: Summary in proceedings
Title: a COMPARISON ...
- Authors:
- Pivac, Nediljko (146831)
- Dobovišek, Jurij
- Gros-Furek, Veronika
- Rumboldt, Zvonko (36500)
- Šimunić, Miroslav (146175)
- Naranča, Mario (193596)
- Bagatin, Jugoslav (61246)
- SARDELIĆ, SANDA (187195)
Year: 1992
Pages: from 120 to 120
Meeting: 1st European Congress on Clinical Pharmacology and Toxicology Services
Held: from 09/16/92 to 09/18/92
Summary: In a multicenter, double-blind clinical trial, the
efficiacy andacceptability of amlodipine (5-10 mg o.d.) and of
sustained-release nifedipine (20-40 mg b.i.d.) were compared. After a
two-weekplacebo period, 71 essential hypertensives of both sexes,
aged51.7+/-8.5 years and having diastolic blood pressure of 95-114 mmHg
were randomly allocated to either amlodipine 5 mg once daily(group A) or
nifedipine 20 mg twice daily (group B). With respectto the blood pressure
response, the initial dose was doubledafter two weeks. There were no
significant differences betweenthe blood pressures recorded at baseline and
atthe end of theplacebo period. Already at the first visit (two days after
theinitiation of active treatment), there wasa significant reductionin
both, systolic and diastolic blood pressure in the supineposition. In the
group A it decreased from 163.2+/21.4/102.7+/-8.5 to
155.7+/-20.7/98.2+/-8.9 mm Hg (p<0.05) and in the group B
from 160.5+/-16.2/100.5+/-12.2 to 152.2+/-17.0/95.4+/-9.5 mm Hg(p<0.05).
Similar changes of blood pressure were observed in the
standing position, as well. At the end of the study a totalreduction of the
supine diastolic blood pressure was 12.5% in theGroup A versus 5.2% in the
group B (p<0.05). In the standing posi
tion amlodipine decreased diastolic blood pressure by 8.8% andnifedipine by
6.4% (p<0.05). Furthermore, amlodipine decreasedthe standing diastolic
blood pressure to a greater extent (8.8%vs. 6.4%, p<0.05) than nifedipine.
A 24-hour maintenance of theachieved goal blood pressure was confirmed in
8patients from eachgroup, using continued ambulatory monitoring. The
side-effectswere recorded equally in both groups (peripheral
oedema,headache, palpitations, nausea), but were more intense in
thenifedipine group. We conclude that between the studied calciumchannel
blockers, amlodipine is marginally superior to nifedipinein the treatment
of mild to moderate hypertension.
- Type of paper
: Summary in proceedings
Title: THE IMPACT ...
- Authors:
- Rumboldt, Mirjana (111354)
- Pesenti, Serafina (111391)
- Rumboldt, Zvonko (36500)
Language: engleski
Pages: from 97 to 97
Meeting: Congress of the european union for school and university health and medicine
Held: from 07/01/93 to 07/03/93
Summary: In order to assess the influence of the war calamities
onthepupils growth rate, compared were the heights, weights, andrelative
weights of children from Split (South Croatia) at thetime of entering two
major elementary schools (age about 6.5years), and some 10 montha later,
during the two pre-war years(i.e. 1988/89 and 1989/90) and the two years of
the war againstCroatia (i.e. 1990/91 and 1991/92). A notable increase in
bodyweight, ranging from 12.24 to 14.50%, compared to 8.57-11-93% inthe
pre-war years (t=1.23, p>0.05) but not in height was observedin the first
year of war. Conversely, a significant accelerationin the longitudinal
growth (4.55-4.73% as compared to3.38-4.24%;t=4.01, p<0.01) but not in the
weight gain was notedin the second year of war. These unexpected findings
lead toconclusion that the war atrocities may differently affect
thechildren growth rate, depending the amount and quality of theconsumed
food, on the level of energy expenditure, and possiblyon the variable
impact of the cortical brain activity upon thesynthesis and/or incretion of
the growth mediators.
- Type of paper
: Summary in proceedings
Title: PECULIARITIES ...
- Authors:
- Rumboldt, Zvonko (36500)
- Rumboldt, Mirjana (111354)
- Pesenti, Serafina (111391)
- Polić, Stojan (77340)
- MIRIĆ, DINKO
Year: 1993
Pages: from 18 to 18
Meeting: 1st Alpe-Adria cardiology meeting
Held: from 05/21/93 to 05/22/93
Summary: The records of all the patients admitted because of
acutemyocardial infarction (AMI) to Clinical Hospital Split between1987 and
1991 have been evaluated. In that 5-year period therewere complexively 1
406 such patients, of which 130 (9.2%) belowthe limit of 45 years. In this,
younger group there were only 9(6.9%) females, which is significantly less
than among the olderpatients (399 of 1276 or31.3%; p<0.05). Among the
younger therewere much more smokers (76.9 vs.41.1%;p<0.01), the
infarctlocalization was predominantly inferior, which was not the casein
those above 45 years (50.0 vs. 34.6%;p<0.01), and the hospitalmortality in
younger AMI patients was substantially lower (6.2vs. 22.1%;p<0.001). It is
concluded that AMI in younger personsis characterized by high prevalence of
the female gender (almostfour times less), high prevalence of diaphragmatic
location(nearly two times greater) and that the hospital mortality ismuch
lower (almost fourfold) than in persons over 45 of age.
- Type of paper
: Summary in proceedings
Title: CARDIOVASCULAR ...
- Authors:
- Rumboldt, Mirjana (111354)
- Rumboldt, Zvonko (36500)
Language: engleski
Year: 1991
Pages: from 23 to 23
Meeting: 2nd Alpe Adria Cardiology Meeting
Summary: From 1982 to 1988 a longitudinal, prospective study
ofcardiovascular risk factors was conducted on a sample of 448pupils (198
boys and 250 girls), with the starting age of11.2+/-0.56 years. The
following risk factors were analyzed:systolic and diastolic blood pressure,
relative weight,cholesterol, and triglycerides. The values above the
90.percentile for age and gender were considered elevated. In thefirst year
of the study there were 116 pupils "at risk" (55 boysand 61 girls). The
most prevalent risk factor at that time wasthe systolic blood pressure (in
50.9% of the "risky" boys and42.7% of the "risky" girls), and cholesterol
(40.0% of the boys,44.3% of the girls). At the end of the sixth year of
this follow-up the same factors were the most prevalent, albeit to a
minordegree (systolic pressure in 29.4% of the boys, and 15.6% of thegirls,
cholesterol in 11.8% of the boys, and 21.9% of thegirls). In the first
study yearthe majority (45.7%) of the"risky" pupils were having only one
risk factor, while at the endthe most prevalent were those with two of them
(36.4%). Thepersistence ("tracking") of risk factors was highest for
therelative weight (r=0.9) and for cholesterol (r=0.8), and lowestfor
triglycerides (r=o.1) in this study. It is concluded thatunderstanding and
knowledge of risk factors in childhood maysubstantially contribute to the
prevention of cardiovasculardisease in adulthood.
- Type of paper
: Summary in proceedings
Title: DRUG ...
- Authors:
- Bagatin, Jugoslav (61246)
- Pivac, Nediljko (146831)
- SARDELIĆ, SANDA (187195)
- Rumboldt, Zvonko (36500)
- Šimunić, Miroslav (146175)
- Naranča, Mario (193596)
- KORLJAN-BABIĆ, BETTY
Language: engleski
Year: 1992
Pages: from 126 to 126
Meeting: 1st European Congress on Clinical Pharmacology and Toxicology Services
Held: from 09/16/92 to 09/18/92
Summary: Analysed was the drug consumption profile at the
Departments ofMedicine and Surgery in Clinical Hospital Split, Croatia,
andcompared with the results of previous similar surveys. In April1992, 123
charts of internal and 164 of surgical patients havebeen analysed. The
average number of drugs prescribed per patientwas 3,41 +/- 2,04 in the
medical and 4,01 +/- 3,31 in thesurgical wards (t=1,89 ,p>0,05). The
leading drugs in surgicalpatients were the antimicrobials (27,3%), followed
by bloodpreparations or substitues (24,6%), and drugs that act on
thenervous system, mostly analgesics (15,9%). The actual profile isnot
unexpected since the majority of admissions were due towounds (in 1991 and
1992 the region of Split was directlyincluded in war operations in Croatia,
as well as in Bosnia andHerzegovina). At the Department of Medicine the
leading positionwas held by cardiovascular drugs (20,0%), the second by
diuretics(15,0%), and the third by antimicrobials (10,7%). The profile
wassimilar to that of 1988, but quantitatively less (t=2,09,p<0,05), by 16
per cent. At the Department of Surgery theaverage drug utilization was not
significantly changed incomparison wirh 1984 (4,01 +/- 3,31 vs. 4,02 +/-
2,45 drugs perpatient), but significantly greater than in 1988 (4,01 +/-
3,31vs. 2,06 +/- 1,43 , t=6,72 ,p<0,05), which could be explained bythe war
situation. The decrease in consumption of some drugs andthe better quality
of drug utilization profile point to thepositive influence of educational
efforts in the field ofrational pharmacotherapy and to the favourable trend
in drugconsumption in this hospital, which however is not immune to
theradically altered circumstances, such as incredibile wardevastation and
the large number of victims.
- Type of paper
: Summary in proceedings
Title: A comparison of diuretic efficiency of continuous
intrevenous infusion and conventional bolus injection of furosemide in
congestive heart failure
- Authors:
- Bagatin, Jugoslav (61246)
- SARDELIĆ, SANDA (187195)
- Drinovec, JOŽE
- Rumboldt, Zvonko (36500)
- Polić, Stojan (77340)
- MIRIĆ, DINKO
- Pivac, Nediljko (146831)
Language: hrvatski
Place: Opatija
Year: 1993
Pages: from 136 to 136
Meeting: 1. KONGRES HRVATSKOG KARDIOLOŠKOG DRUŠTVA
Held: from 04/22/93 to 04/24/93
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Bagatin, Jugoslav (61246)
- SARDELIĆ, SANDA (187195)
- Rumboldt, Zvonko (36500)
- Polić, Stojan (77340)
- Pivac, Nediljko (146831)
Proceedings title: Proceedings of the 2nd Alpe Adria Cardiology Meeting
Language: engleski
Place: Brijuni, Hrvatska
Year: 1994
Pages: from 120 to 120
Meeting: 2nd Alpe Adria Cardiology Meeting
Held: from 06/22/94 to 06/25/94
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Šimunić, Miroslav (146175)
- Rumboldt, Zvonko (36500)
- Polić, Stojan (77340)
- Ljutić, Dragan (132855)
- SARDELIĆ, SANDA (187195)
- Lukin, Ajvor
Proceedings title: Proceedings of the 2nd Alpe Adria Cardiology Meeting
Language: engleski
Place: Brijuni, Hrvatska
Year: 1994
Pages: from 119 to 119
Meeting: 2nd Alpe Adria Cardiology Meeting
Held: from 06/22/94 to 06/25/94
Summary: The purpose of the present study was to compare the
antihypertensive effects and electrolyte changes in outpatients wuth mild
to moderate essential hypertension treated with chlorthalidone or its
combination with ramipril. In a double-blind study, 32 successive
hypertensives of both sexes, 51+/-9 years old, with an average blood
pressure of 181.4/104.5 +/- 13.0/6.9 mm Hg were investigated. Following
four week placebo period, patients were randomly given either a combination
of 5 mg ramipril with 25 mg chlorthalidone (group A, n=17), or 25 mg of
chlorthalidone as monotherapy (n=15, group B).After twelve weeks of such a
treatment patients in group A had significantly lower blood pressure than
patients in group B. At the end of the trial, serum creatinine increased in
group A significantly, from 87.3+/-12 to 93.8+/-16.8 umol/l, but eas almost
unchanged in group B. Mmagnesiuria increased significantly in group B,
whilče in group A it remained unchanged. We conclude that
ramipril-chlorthalidone combination has stronger antihypertensive effect
as than chlorthalidone monotherapy. potential magnesium - sparing effect of
ramipril is yet to be assessed in further studies.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Rakić, Drago (121684)
- Rumboldt, Zvonko (36500)
- Tukić, Ante
- MIRIĆ, DINKO
- SARDELIĆ, SANDA (187195)
Proceedings title: 2nd Alpe Adria cardiology Meeting - Abstract book
Language: engleski
Place: Brijuni, Hrvatska
Year: 1994
Pages: from 54 to 54
Meeting: 2nd Alpe Adria Cardiology Meeting
Held: from 06/22/94 to 06/25/94
Summary: In 25 hypertensives with ecg signs of left ventricular
hypertrophy (LVH), in 25 hypertensives without LVH, and in 25 normotensive
subjects, analyzed was the occurence of cardiac arrhythmias by means of
continuous ambulatory ecg monitoring.
Nonsustained VT runs occured in 8 LVH examinees (#"%), in 3 hypertensives
without LVH (12%) and in 1 control subject (4%). the average number of PVBs
was significantly higher in LVH hypertensives (569 vs. 368 vs. 39, p<0.01).
Paroxysmal SV tachycardia was more frequent in LVH hypertensives than in
the other subgroups, as well (24 vs. 12 vs. 8%, p<0.05). The prevalence of
arrhythmia was not positively correlated to diuretic therapy, however.
It is concluded that the probability of heart arrhythmias is much higher in
hypertensives than in normotensives, and that LVH further enhances this
trend. Low-dosed diuretics do not increase the arrhythmogenic potential,
which was often described with high/standard dosage of these drugs.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- MIRIĆ, DINKO
- Rumboldt, Zvonko (36500)
- Eterović, D.
- Čapkun, Vesna
- Bagatin, Jugoslav (61246)
- Polić, Stojan (77340)
Proceedings title: Knjiga sažetaka 1. Kongresa hrvatskoga kardiološkoga društva
Language: hrvatski
Place: Opatija
Year: 1993
Pages: from 17
Meeting: 1. KONGRES HRVATSKOG KARDIOLOŠKOG DRUŠTVA
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Polić, Stojan (77340)
- Lukin, Ajvor
- Rumboldt, Zvonko (36500)
- Bagatin, Jugoslav (61246)
- MIRIĆ, DINKO
- Rakić, Drago (121684)
- Forempoher, Gea
Proceedings title: Knjiga sažetaka 1. Kongresa hrvatskoga kardiološkoga društva
Language: hrvatski
Place: Opatija
Year: 1993
Pages: to 59
Meeting: 1. KONGRES HRVATSKOG KARDIOLOŠKOG DRUŠTVA
- Type of paper
: Ph.D.
Title: A comparison of thiazides and beta-blockers in long-term
treatment of arterial hypertension
Faculty: Medicinski Zagreb
Author: BAGATIN JUGOSLAV
Date of defense: 10/14/94
Language: hrvatski
Number of pages: 96
- Type of paper
: M.A.
Title: Reactivity of peripheral veins in patients with chronic
renal failure evaluated by venoconstriction test
Faculty: Medicinski Zagreb
Author: SARDELIĆ SANDA
Date of defense: 06/20/95
Language: hrvatski
Number of pages: 97
Summary: The data obtained in the presented study show a
considerable role of the venous system in blood pressure control in
patients treated with chronic intermittent hemodialysis. Hypotensive
dialysis patients display reduced venous responsiveness to a locally
injected noradrenaline, as well as diminished reflexly mediated
venoconstriction. In remaining, clinically stable hemodialysed patients an
enhanced noradrenaline-mediated venoconstriction was observed, which
probably contributes to the pathogensis of arterial hypertension in those
patients. Increased venous capacity and maximal venous outflow, possibly
participate in hemodynamic instability of hypotension prone dialysis
patients. Saline infusions during hemodialysis and elastic stockings on
lower extremities at the end of the procedure are at this point of
incomplete knowledge the only acceptable clinical recommendations.
Keywords: veins, chronic renal failure, haemodialysis, vascular reactivity, venoconstriction test, plethysmography, autonomic nevous system, hypotension
- Type of paper
: M.A.
Title: The effect of antihypertensive treatment on kations'
metabolism, especially on magnesium
Faculty: Medicinski Zagreb
Author: ŠIMUNIĆ MIROSLAV
Date of defense: 04/18/94
Language: hrvatski
Number of pages: 68
Keywords: ramipril, chlorthalidone, arterial hypertension, treatment, biochemical disturbancies, kations, magnesium
- Type of paper
: M.A.
Title: A comparison of antihypertensive effects of endovenous
bolus injection and continuous furosemide infusion in congestive heart
failure patients
Faculty: Medicinski Zagreb
Author: PIVAC NEDILJKO
Language: hrvatski
Number of pages: 71
- Type of paper
: M.A.
Title:
Faculty: Medicinski Zagreb
Author: NARANČA MARIO
Language: hrvatski
- Type of paper
: Mentorship
Title: Reactivity of peripheral veins in patients with chronic
renal failure evaluated by venoconstriction test
Faculty: Medicinski Zagreb
Mentor: LJUTIĆ DRAGAN
Date of defense: 06/20/95
Number of pages: 97
Author: SARDELIĆ mr.sc.dr., mladi istraživač SANDA
Degree level: M.A.
- Type of paper
: Mentorship
Title: The effect of antihypertensive treatment on kations'
metabolism, especially on magnesium
Faculty: Medicinski Zagreb
Mentor: RUMBOLDT ZVONKO
Date of defense: 04/18/94
Number of pages: 68
Author: Šimunić Miroslav
Degree level: M.A.
- Type of paper
: Mentorship
Title: A comparison of thiazides and beta-blockers in long-term
treatment of arterial hypertension
Faculty: Medicinski Zagreb
Mentor: RUMBOLDT ZVONKO
Date of defense: 10/14/94
Number of pages: 96
Author: Bagatin Jugoslav
Degree level: Ph.D.
