SVIBOR - Project code: 3-01-238

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Project code: 3-01-238


THE STUDY OF ETIOLOGY, PATHOGENESIS, AND PHARMACOTHERAPY OF ARTERIAL HYPERTENSION


Main researcher: BAGATIN, JUGOSLAV (61246)


Assistants
Type of research: applied
Duration from: 01/01/91. to 12/31/95.
Papers on project (total): 72
Papers on project quoted in Current Contents: 12
Institution name: Bolnica "Firule", Split (141)
Department/Institute: DEPARTMENT OF INTERNAL MEDICINE DIVISION OF CLINICAL PHARMACOLOGY AND TOXICOLOGY
Address: SPINČIĆEVA 1, 58 000 SPLIT
City: 21000 - Split, Croatia
Communication
Fax: 385 (0)21 356738
Phone: 385 (0)21 515055
Summary: In a prospective, randomized, clinical investigation approximate ly 500 persons, including school children, adolescents and adults , with moderate arterial hypertension and diastolic blood press ure below 115 mm Hg, will be studied. In the group of school chi ldren and adolescent persons, we shall continuously investigate the following parameters: prevalence and incidence of arterial hy pertension, standard and relative weight, serum cholesterol and triglycerides, as well as the influence of physical activity on those facors. The children with positive family history of hypert ension or myocardial infarction will be also followed up. The role of the human atrial natriuretic factor (ANF), endoxin, a nd insulin in pathogenesis of hypertension will be assessed. The group of adult hypertensives will be randomly assigned to either diuretic or beta-blocking agent during six months, followed by the alternative six months therapy regime. Changes in blood pressure, cholesterol and triglyceride levels, electrolytes and serum glucose, as well as the potential vasoactivity of those antihypertensives, will be studied. In the third group of hyperte nsives with left ventricular hypertrophy, four different antihype rtensive drugs, and their impact on regression of hypertrophy, wi ll be investigated. 24-hours blood pressure monitoring will be us ed in the fourth group of mild to moderate hypertensives in order to assess the prevalence of the false positive results and especially the prevalence of the "white coat hypertension", as well as to determine the possible prognostic implications of such results.

Keywords: ARTERIAL HYPERTENSION, LEFT VENTRICULAR HYPERTROPHY, CARDIOVASCU LAR RISK FACTORS, CONTINUOUS BLOOD PRESSURE MONITORING, ATRIOPEP TIN (ANF), ENDOXIN, INSULIN

Research goals: 1. To assess the influence of the endoxin, atrial natriuretic fac tor (ANF) and insulin on blood pressure. Measuring the baseline v alues of the ANF and endoxin, as well as the values induced with the glucose and insulin, before and after antihypertensive treatm ent, to evaluate the influence of insulin, and insulin-induced hy poglycaemia on ANF and endoxin levels in normotensive and hypert ensive examinees. 2. To assess the family aggregation of the cardiovascular risk fa ctors in school children and adolescents. To point out the most a ppropriate diagnostic and therapeutic procedure. 3. Using the 24-hours ambulatory blood pressure monitoring to evaluate the earlier established hypertension, and to assess the prevalence of the "white cout hypertension" in the region of Dalm atia. 4. To assess the efficiency and metabolic side-effects during the log-term treatment with tiazide diuretics and beta blockers. 5. To determine the effects of four group of antihypertensives (i.e. diuretics, beta blockers, calcium channel blockers and vaso dilatators) on regression of left ventricular mass, diastolic fun ction, and especially excitability of left ventricle.

COOPERATION - PROJECTS


  1. Name of project: 3-01-235 Izučavanje optimalnog kardiotoničkog liječenja
    Name of institution: Odjel za bolesti srca i krvnih žila, Klinička bolnica Split
    City: 21000 - Split, Croatia

COOPERATION - INSTITUTIONS


  1. Name of institution: Zavod za kliničku farmakologiju, Klinički bolnički centar Rebro
    Type of institution: International organization
    City: 10000 - Zagreb, Croatia

OTHER ACHIEVEMENTS


  1. Name: Racionalna farmakoterapija u kardioangiologiji - Tečaj trajnog usavršavanja liječnika
    Type of achievement: Other
    Authors: Organizatori tečaja: Stojan Polić, Jugoslav Bagatin
Other information about the project.
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Last update: 10/11/95
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