SVIBOR - Project code: 3-01-242

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-242


MULTIFACTORIAL RESEARCH OF NONMALIGNANT LYMPHADENOPATHY


Main researcher: JEREN, TATJANA (74864)



Assistants
Type of research: developmental
Duration from: 12/29/90. to 02/23/94.

Papers on project (total): 26
Papers on project quoted in Current Contents: 4
Institution name: Bolnica "Dr. Fran Mihaljević", Zagreb (143)
Department/Institute: UNIVERSITY HOSPITAL FOR INFECTIOUS DISEASES ZAGREB HEMATOLOGICAL AND CYTOLOGIC LABORATORY
Address: Mirogojska 8, 41000 ZAGREB, CROATIA
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)1 4557222
Fax: 385 (0)1 425907

Summary: Nonmalignant lymphadenopathy occurs in 80% of all lymphadenopathies in age up to 40 years, and after this age about 40% of clinically manifested lymphadenopaties are nonmalignant. In the whole world 18-30% of nonmalignant lymphadenopathies are of unknown etiology, being a major problem in treatment, in prognosis of the outcome of the disease and in evaluation of working ability of such a patient. This work should help to find the solution to these problems as follows: a) by clinical and etiological researches b) by morphologic, cytochemical and immunocytochemical researches c) by objective evaluation of obtained results for making a long - term prognosis. A total number of 104 patients with lymphodenopathy has been treated so far in the work, partly in the out-patient department and partly in the hospital. After diagnostic, clinical and cytological procedure the malignant disease was excluded in all of them. During the period of 1994-95 other 34 patients were treated, according the proposition of this project. Their diagnoses were: Syndroma mononucleosis inf.caused by EBV 9; Syndroma mononucleosis inf.caused by CMV 3; TBC of lymph nodes 3; Cat scrach dis. 5; Toxoplasmosis 6; AIDS 3; Unknownn 3; Total 34 The etiology was known in 74 cases (infectious mononucleosis, toxoplasmosis, cat scratch disease, EBV lymphadenopathy, tuberculosis, lymphogranuloma venereum, AIDS), and in 27 cases the etiology was unknown. The most frequent types of cytologic reaction in examined lymph nodes were: reactive hyperplasia (various types) and granulomatous reaction. The cytologic status of control fine needle aspirates was sometimes different in relation to the previous one, that was reported as a dynamics in the course of evolution of inflammation. The subpopulations of T-lymphocytes (CD 4, CD 8, NK cells) and the cells with monocytic marks were examined by immunocytochemical methods. At the beggining of 1995 the PCR methods were performed in some special cases of unclear nonmalignant lymphadenopathy. For the time being we can prove the genetic material for AIDS, TBC and Chlamidiae.

Keywords: lymphadenopathy, etiology, cytology, immunocytochemistry, reactive lymphatic hyperplasia

Research goals: The aim of this examination is to range by a modern processing(as under a,b,c,d and e) the patients with nonmalignantlymphadenopathies into some clinical and cytologic entities andthus to estimate the course, treatment and prognosis of thedisease, as well as to give final evaluation of working ability.It is important specially in those cases when routine diagnosticprocedures are not available in making etiologic diagnosis (23), as per our research.


COOPERATION - PROJECTS


  1. Name of project: 0


COOPERATION - INSTITUTIONS


  1. Name of institution: 0

  2. Name of institution: Institut "Ruđer Bošković"- Odjel za molekularnu medicinu
    Type of institution: State institute
    Type of cooperation: Other
    City: 10000 - Zagreb, Croatia

  3. Name of institution: Darthmounth-Hitchcoch Medical School
    Type of institution: University/Faculty
    Type of cooperation: Occasional exchange of experts
    City: Lebanon, USA

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Last update: 09/29/95
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