SVIBOR - Project code: 3-01-246

MINISTRY OF SCIENCE AND TECHNOLOGY

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Project code: 3-01-246


QUANTITATIVE MEASUREMENTS OF RADIOPHARMACEUTICAL BIODISTRIBUTION


Main researcher: IVANČEVIĆ, DARKO (17150)


Assistants
Type of research: applied
Duration from: 01/01/91. to 12/31/93.
Papers on project (total): 34
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Clinical Nuclear Department of Nuclear medicine and Clinical Hospital Center Rebro
Address: Kišpatićeva 12
City: 10000 - Zagreb, Croatia
Communication
Summary: The biodistribution of radiopharmaceuticals has been studied by quantitative computerized scintigraphy. In 74 patients after acute myocardial infarction (44 with and 30 without silent ischemia) sensitivity and specificity was compared for: early stress test, Holter and quantitative scintigraphy with Tl-201 and conclusion was that superior sensitivity and predictivity indicates the use of scintigraphy in asymptomatic patients after acute infarction. 43 controls, 52 patienst with Crohn's disease and 19 with ulcerative colitis were studied by clinical methods and numeric indices and with quantitative scintigraphy and emission computerized tomography with leukocytes labeled with Tc-99m-HMPAO. 113 children with vesicouretheral reflux were studied by dynamic scintigraphy with Tc-99m-DTPA and deconvolution renographic curves. By original method of functional images of the mean time of radiopharmaceutical the intrarenal reflux- important factor of reflux nephropathy -was determined.The three-phase scintigram with Tc-99m-MDP was more sensitive than any radiological method in patients with stress syndrome and stress fractures. Single photon scintigraphy with Tc-99m-HMPAO in 15 children with epilepsy could localize epileptogenic zone. Quantitative lung scintigraphy with Ga-67 was useful in evaluation of pulmonary disease course.Our own originally designed collimator improved the measurement of body activity retention. Quantitative studies of three-dimensional distribution of labeled compounds in body have significant advantages over other functional studies.

Keywords: Scintigraphy, SPECT, radiopharmaceuticals, silent ischemia, inflammatory bowel diseases, overuse injuries, reflux nephropathy, cerebrovascular insult, chronic obstructive pulmonary disease.

Research goals: The objective of the study was introduction, development, evaluation and clinical application of quantitative methods for biodistribution studies of radiopharmaceuticals in the body by using in vivo methods with scintigraphy, computerized scintigraphy and single photon emission computerized tomography. The study comprised a number of pharmaceuticals, mostly Tc-99m compounds, especially for detection of inflammation and for perfusion studies. Studies were performed in groups of patients with silent myocardial ischemia, inflammatory gut diseases, stress syndrome of locomotor system, reflux nephropathy, lung disorders and epilepsy, as well as in controls. These studies have enabled objective quantification of nuclear medicine scintigraphic findings and evaluation of quantitative parameters with other medical methods. In the same time the understandings and scientific benefits in some pathophysiological problems connected with diseases under studies were achieved.

COOPERATION - INSTITUTIONS


  1. Name of institution: Institut de protection et de surete nucleaire, Centre d'etudes de Fontenay-aux-Roses, Directeur de recherche Dr. J.-C. Nenot
    Type of institution: University/Faculty
    City: Fontenay-aux-Roses, Francuska
Other information about the project.
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Last update: 10/09/95
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