SVIBOR - Project code: 3-01-254

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

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Project code: 3-01-254


PEPTIDOGLYCAN MONOMER AND DERIVATIVES


Main researcher: PLAVŠIĆ, FRANJO (37512)


Assistants
Type of research: developmental
Duration from: 01/01/91. to 12/15/95.
Papers on project (total): 69
Papers on project quoted in Current Contents: 6
Institution name: KBC, Znanstvena jedinica za patobiokemijska i klinička istraživanja, Zagreb (167)
Department/Institute: Center for Biomedical Research
Address: Šalata 2
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)41 42-80-19
Fax: 385 (0)41 42-80-12
Summary: The activity of peptidoglycan monomer and its pharmacokinetics will be studied. Among biological activities, the influence of peptidoglycan monomer on humoral and cell activity; immunostimulation characteristics and other effects on the organism will be studied. By toxicological research acute and chronic toxicity, reproduction toxicity and genotoxicity of peptidoglycan monomer will be examined. Pharmacokinetical studies will include the experiment with labelled peptidoglycan monomer and pharmacokinetics with application of suitable analytical method for measuring in biological material. In preliminary research, the suitable computer pharmacokinetic model for calculation of pharmacokinetic parameters from experimental data will be established.

Keywords: Peptidoglycan monomer, humoral, cell, immunostimulating, pharmacokinetic, toxicology, genotoxicity.

Research goals: The goal of further studies is to clear up the activity mechanism, to find out the additional activities and to clear up pharmacokinetics in the animal model. Concerning the activity study, immunostimulation characteristics will be examined in conditions of experimentally produced immunodepression, similar to immunodepression that can appear on clinics after the general endotracheal anaesthesia. Activity against the viral infection will be examined on a submersed human leukocyte culture concerning the ability of peptidoglycan monomer to provoke interferon and other lymphokines production. The main goal of the pharmacokinetical research is to achieve the conditions (if pharmacodinamical and toxicological results are positive) for pharmacological opinion, necessary for approval license to start the first phase of clinical trials. At the same time the efforts to find out the appropriate analytical method for peptidoglycan monomer measuring in suitable biological materials will be done. Besides, the several pharmacokinetical models will be set up and check out, verified by application on pharmacokinetics of well-known drugs in animal and human models. Tissue distribution of drugs, specially of peptidoglycan monomer and its kinetics will be of special interest.
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Last update: 10/16/95
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