SVIBOR - Project code: 3-01-264

MINISTRY OF SCIENCE AND TECHNOLOGY

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Project code: 3-01-264

Early detection of pulmonary microembolization utilising transfer factor

Main researcher: DUJIĆ, ŽELJKO (160325)

Assistants

ETEROVIĆ, DAVOR (172242)

Type of research: applied
Duration from: 01/01/91. to 01/01/94.

Papers on project (total): 12
Papers on project quoted in Current Contents: 10

Institution name: Medicinski fakultet, Zagreb (108)

Communication

Summary: The aims of this work were to evaluate the potentials of the lung transfer factor for CO (TLCO) to detect the post-diving microemolization by inert gas and to use this noninvasive model for diagnosis in patients with pulmonary embolism. In the group of professional divers various cardiopulmonary paramaters were measured before, during and after dry diving at 45 m/25 min. A transient decreases in TLCO and oxygen partial pressure in arterial blood were observed after the dive, while an increase in TLCO was found during diving. The results show that even mild diving protocol induces significant pulmonary microembolization and hypoxemia and that TLCO is potentially important in clinical embolizations.

Keywords: hyperbaric chamber, dry diving, precordial doppler, pulmonary microembolization, pulmonary embolism, pulmonary function, diffusing lung capacity, hypoxemia

Research goals: The goal of this investigation is the evalutaion of the new method for assessment of the impact of diving on the pulmonary function utilising TLCO and extrapolation of this noninvasive human model to clinical embolisms. The possibility of reevaluation of decompression tables, utilising diving-induced TLCO changes, as the main parameter, is anticipated. The own modification of the TLCO measuring technique could be the novel method for detection and follow-up of clinical pulmonary embolism.

Other information about the project.


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