SVIBOR - Project code: 3-01-275

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-275


ATYPICAL MONONUCLEAR CELLS (AMC) - CHARACTERISTICS AND ORIGIN


Main researcher: SOFTIĆ, NIJAZ (43913)



Assistants
Type of research: applied
Duration from: 01/01/91. to 12/31/94.

Papers on project (total): 12
Papers on project quoted in Current Contents: 1
Institution name: Farmaceutsko-biokemijski fakultet, Zagreb (6)
Department/Institute: Department of hematology
Address: Ante Kovačića 1
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)41 44-53-11

Summary: We studied morphological, cytochemical, cytoenzymatic and immunologic characteristics, genesis and ultrastructure of atypical mononuclear cells (AMC) and lymphocytes of peripheral blood and lymphoid organs in patients with the syndrome of infectious mononucleosis of various etiology. Appropriate specific tests and methods were included in the study.

Keywords: infectious mononucleosis - syndromes, AMC, B lymphocytes, T lymphocytes, NK cells

Research goals: Studies of morphological, ultrastructural, cytochemical, cytoenzymatic and immunologic characteristics of lymphocytes and atypical mononuclear cells (AMC), their etiology in the blood and lymphoid organs of patients with the syndrome of infectious mononucleosis of various etiology. 2. Determination of specificity for each morphological group of the AMC on the basis of the activity index of each enzyme in the AMC. 3. Study of T and B lymphocytes reactivity and simultaneous investigation of morphological, cytochemical and cytoenzymatic characteristics of transformed cells in lymphocyte cultures of healthy subjects and AMC in the peripheral blood and lymph node punctates in patients. 4. Studies of lymphocite subpopulations and NK cells and their role in pathogenic mechanism of infectious mononucleosis syndrome of various etiology. Results in these studies will represent scientific contribution to knowledge about morphological, cytochemical, cytoenzymatic and immunologic characteristics of the AMC and about their etiology in patients with infectious mononucleosis syndrome of various etiology. Data on the role of humoral and cellular immunity in the pathogenesis of the mentioned syndromes will be obtained as well.


COOPERATION - INSTITUTIONS


  1. Name of institution: Klinika za infektivne bolesti "Dr Fran Mihaljević"
    Type of institution: International organization
    City: 10000 - Zagreb, Croatia

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Last update: 10/12/95
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