Journal: GASTROENTEROHEPATOLOŠKI ARHIV
Number: NITE Volume: II U Year: 1993 Pages: from 146 to 0 Number of references: 103 Language: engleski Summary: There are no completely reliable methods for predicting
relapsein Crohn's disease. We studied prospectively 45 patients withcrohn's
disease in remission for 8 months period. The activity ofdisease was
monitored by CDAI calculation and by followinglaboratory parameters: ESR
(first hour),fibrinogen,alpha-l-antitrypsin and alpha-l-glycoprotein.
Statistical differences in CDAI values and laboratorymeasurements between
patients who later relapsed and those whoremained in remission were
evaluated by Student t-test.
Table l and 2. ommitted.
Conclusion: alfa-l-glycoprotein was the only acute phase proteinwhich
showed predictive value regarding impending relapse. Allstudied parameters
increased significantly at the time ofrelapse. Identification of patients
in clinical remission withhigh risk of relapse might indicate early
treatment. Keywords: Crohn's disease, acute phase proteins, relapse prediction.