SVIBOR - Project code: 3-01-342


Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69


SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-342


Main researcher: VUCELIĆ, BORISLAV (116793)

Type of research: applied
Duration from: 01/01/91. to 12/31/94.

Papers on project (total): 14
Papers on project quoted in Current Contents: 3
Institution name: Medicinski fakultet, Zagreb (108)
Fax: 385 (0)41 218-461
Phone: 385 (0)41 218-461

Summary: Epidemiological study will be done in several regions of Republic of Croatia in order to recognize possible regional differences. Number of laboratory parameters will be evaluated in connection with the activity of the disease with final effort to produce a new disease activity index.Above parameters will be correlated not only with the activity of the disease but also as predictors for recognition of the relapse, remission and effects of the therapy.Clinical trials will be performed in order to evaluate new drugs, primarily immunosupresive drugs and new aminosalicilates.Since new surgical procedures were introduced in the previous study period, pouchitis as a new entity will be studied.In order to address a problem of early detection of the cancer of the colon and rectum, number of methods will be prospectively studied like epithelial dysplasia, degree of aneuploidia, mucins and pectins in the bowel lumen.

Keywords: Ulcerative colitis, Crohn's disease, epidemiology, acute reactants, bowel scan with labeled autologous leucocytes, cancer detection, pouchitis, new drugs.

Research goals: Epidemiological study is vital for the assessment of the incidence and prevalence of IBD in the entire country, for the recognition of regional differences which might point to possible etiological factors and for the identification of risk factors, some of which are already described (smoking,contraceptives, sugar consumption).Accurate epidemiological data are essential for health planning. The assessment of the activity of the disease is a major problem. Various parameters will be evaluated in order to identify those which correlate with activity, which have prognostic value for early recognition of the relapse and those which enable correct interpretation of radiologic and endoscopic findings.The attempt will be made to create new activity index.There are number of indeces already published (Powell-Tuck,CDAI,van Hees, Truelove- Witts) but none is satisfactory.Leucocyte scan of the bowel might solve the problem of interpretation of radiological and endoscopic data, where we already have significant experience (bowel mapping). Major problem in IBD therapy are frequent resistant cases.Therefor we plan to prospectively evaluate immunosupressive therapy (azathioprine, cyclosporine, FK 506) and new amminosalycilates. New surgical procedures will be introduced with study of metabolic consequences.Of special interest is the problem of pouchitis with unknown pathogenesis, where we plan to conduct microbiological and immunological studies. The incidence of cancer is increased in IBD,particularly in ulcerative colitis.It is impossible to detect it early with routine tests, and therefore we plan prospective study of early detection using epithelial dysplasia, changes in bowel mucins and pectines and degree of aneuploidia.


  1. Name of institution: KLINIČKI BOLNIČKI CENTAR
    Type of institution: Economical/Production
    City: 10000 - Zagreb, Croatia

  2. Name of institution: NOVA BOLNICA
    Type of institution: University/Faculty
    City: 10000 - Zagreb, Croatia

Other information about the project.
MZT Croatian language SVIBOR Alphabetic list Sorted on project code Sorted on institutions Search help
Ministry of
Science and
Sorted on
project code
Sorted on
Search Help

Last update: 12/22/95