- Type of paper
: Paper in journal
Title:
- Authors:
- Vucelić, Boris (116793)
- Krznarić, Željko (75865)
- Sentić, Mirna (203891)
- Korać-Kovačević, Bojana (141181)
- Miličić, Davor (161824)
- Ostojić, Rajko (171566)
- Hadžić, Nijaz
- Čvoriščec, Dubravka (8666)
- Stavljenić, Ana
Journal: GASTROENTEROHEPATOLOŠKI ARHIV
Number: 1
Volume: 10
Year: 1991
Pages: from 30 to 32
Number of references: 24
Language: engleski
Summary: The value of serum neopterin in the assessment of activity
of
ulcerative colitis(UC) and Crohn's disease (MC) was evaluated
in the study that included 91 patients, 61 having UC and 30
having MC.Based on Powell-Tuck index,19 patients with UC had
active disease and those patients had higher serum neopterin
concentrations (p<0,01).Serum neopterin concentrations and
values of Powell-Tuck index were in positive linear correlation
(r=0,5065 p<0,001).The activity of MC was assessed with CDAI
and van Hees index.Based on CDAI, only 4 patients had active
disease.Using van Hees index, 17 patients were in partial
remission and 13 had active disease. Serum neopterin did not
correlate with activity regardless of the index used.
It can be concluded that serum neopterin correlates with the
activity status of UC but not MC.
Keywords: Neopterin, ulcerative colitis, Crohn's disease
- Type of paper
: Paper in journal
Title: ULCEROZNI KOLITIS U ZAGREBU:INCIDENCIJA I PREVALENCIJA
1980-1989.
- Authors:
- Vucelić, Boris (116793)
- Korać-Kovačević, Bojana (141181)
- Sentić, Mirna (203891)
- Miličić, Davor (161824)
- Hadžić, Nijaz
- Jureša, Vesna
- Božikov, Jadranka
- Rotkvić, Ivo
- Buljevac, Mladen (192266)
- Kovačević, Igor
- Tičak, Mirjana
- Makek, Nikola
Journal: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
Number: 4
Volume: 20
Year: 1991
Pages: from 1043 to 1047
Number of references: 24
Language: engleski
Summary: A ten-year incidence of ulcerative colitis in Zagreb
ispresented.The study included both inpatients and outpatients
regardless of the extent and severity of the disease.The mean
annual incidence rate was 1,5/100.000.There was no increase
in incidence of ulcerative colitis during the study period.
A prevalence rate estimate of 21,4/100.000 was based on
July 1985 official estimated population.
Keywords: Ulcerative colitis, Zagreb, incidence, prevalence.
- Type of paper
: Paper in journal
Title: EPIDEMIOLOGIJA CROHNOVE BOLESTI U ZAGREBU, 10-GODIŠNJA
PROSPEKTIVNA STUDIJA
- Authors:
- Vucelić, Boris (116793)
- Korać-Kovačević, Bojana (141181)
- Sentić, Mirna (203891)
- Miličić, Davor (161824)
- Hadžić, Nijaz
- Jureša, Vesna
- Božikov, Jadranka
- Rotkvić, Ivo
- Buljevac, Mladen (192266)
- Kovačević, Igor
- Tičak, Mirjana
- Makek, Nikola
Journal: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
Number: 1
Volume: 20
Year: 1991
Pages: from 216 to 220
Number of references: 21
Language: engleski
Summary: A-ten year prospective study of Crohn's disease was carried
in
Zagreb and included both inpatients and outpatients regardless
of the extent and severity of the disease.The mean annual
incidence rate was 0.7/100.000 without increase during the
study period.The prevalence was 8,3/100.000. The results
confirm the low frequency of Crohn's disease in central
Europe.
Keywords: Crohn's disease, Zagreb, incidence, prevalence.
- Type of paper
: Paper in journal
Title: SERUM ACUTE PHASE PROTEINS IN THE ACTIVITY ASSESSMENT OF
ULCERATIVE COLITIS AND CROHN'S DISEASE
- Authors:
- Vucelić, Boris (116793)
- Miličić, Davor (161824)
- Krznarić, Željko (75865)
- Korać-Kovačević, Bojana (141181)
- Sentić, Mirna (203891)
- Hadžić, Nijaz
- Stavljenić, Ana
- Čvoriščec, Dubravka (8666)
Journal: ACTA MEDICA AUSTRIACA
Number: 4
Volume: 18
Year: 1991
Pages: from 100 to 105
Number of references: 24
Language: njemački
Summary: The activity of UC and MC was assessed by 5 acute
phasereactants:CRP,alpha-1-acid glycoprotein,alpha-1-antitrypsin,
haptoglobin and fibrinogen.We randomly chose 91 patients,
61 with UC and 30 with MC.Statistical analysis was performed
by non-parametric methods:the Kruskal-Wallis and Fisher's
exact test.The disease activity was assessed in UC with Powell-
Tuck index and in MC with CDAI and van Hees index.
Patients with active UC had significantly higher levels of all
acute phase proteins except fibrinogen (p<0,001).Analysis by
Fisher test indicated probability for all measured proteins
to be higher than normal, particularly CRP. In MC paatients,
according to CDAI we found alpha-1-glycoprotein and haptoglobin
to be higher in active disease(p<0,05). Fisher's exact test
indicated that sample was probably not representative.According
to van Hees index,patients with active disease had higher
concentrations of haptoglobin,CRP,alpha-1-antitrypsin and
fibrinogen.Our results confirm that there is no single para-
meter for IBD activity assessment, but these 5 acute phase
proteins with other variables could be useful in the more
precise IBD activity assessment.
Keywords: Inflammatory bowel disease,activity assessment, clinical indices, acute phase proteins.
- Type of paper
: Paper in journal
Title: SERUMSKA KONCENTRACIJA SELENA U BOLESNIKA S ULCEROZNIM
KOLITISOM I CROHNOVOM BOLESTI
- Authors:
- Vucelić, Boris (116793)
- Buljevac, Mladen (192266)
- Romić, Željko
- Miličić, Davor (161824)
- Ostojić, Rajko (171566)
- Krznarić, Željko (75865)
- Korać-Kovačević, Bojana (141181)
- Benković, Jasenka
Journal: THE CROATIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Number: 4
Volume: 1
Year: 1992
Pages: from 171 to 173
Number of references: 17
Language: engleski
Summary: The serum selenium concentration was measured in 202
healthy
volunteers, 45 patients with ulcerative colitis and 25 patients
with Crohn's disease.Mean serum concentrations were for the
control group 66,5 +/- 14,4 micrograms/liter, for UC group
66,5 +/- 14,4 and for MC group 62,0 +/- 14,5.Regarding UC group,
there was no difference from control group, within the group
itself related to sex, extension of disease and duration ofdisease or
activity judged by Powell-Tuck index.Selenium
concentration was lower in MC group than in both other groups.
There was no correlation between selenium concentration and CDAI,
but using van Hees index there was negative correlation.
UC is not expected to be accompanied by hyposelenemia. Crohn's
disease is associated with hyposelenemia, where hyposelenemia
correlates with the disease activity.
Keywords: Ulcerative colitis, Crohn's disease, selenium.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Vucelić, Boris (116793)
- Miličić, Davor (161824)
- Buljevac, Mladen (192266)
- Romić, Željko
- Krznarić, Željko (75865)
- Editors
- Miličić, Davor (161824)
Proceedings title: HELLENIC JOURNAL OF GASTROENTEROL
Language: engleski
Place: ATENA, GRČKA
Year: 1992
Pages: from 376 to 0
Meeting: 1ST UNITED EUROPEAN GASTROENTEROLOGY WEEK
Held: from 09/25/92 to 09/30/92
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Vucelić, Boris (116793)
- Krznarić, Željko (75865)
- Ostojić, Rajko (171566)
- Benković, Jasenka
Proceedings title: II UNITED EUROPEAN GASTROENTEROLOGY WEEK
Language: engleski
Place: BARCELONA, ŠPANJOLSKA
Year: 1993
Pages: from 146 to 0
Meeting: 2ND UNITED EUROPEAN GASTROENTEROLOGY WEEK
Held: from 07/19/93 to 07/24/94
Summary: There are no completely reliable methods for predicting
relapsein Crohn's disease. We studied prospectively 45 patients withcrohn's
disease in remission for 8 months period. The activity ofdisease was
monitored by CDAI calculation and by followinglaboratory parameters: ESR
(first hour),fibrinogen,alpha-l-antitrypsin and alpha-l-glycoprotein.
Statistical differences in CDAI values and laboratorymeasurements between
patients who later relapsed and those whoremained in remission were
evaluated by Student t-test.
Table l and 2. ommitted.
Conclusion: alfa-l-glycoprotein was the only acute phase proteinwhich
showed predictive value regarding impending relapse. Allstudied parameters
increased significantly at the time ofrelapse. Identification of patients
in clinical remission withhigh risk of relapse might indicate early
treatment.
Keywords: Crohn's disease, acute phase proteins, relapse prediction.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Vucelić, Boris (116793)
- Ostojić, Rajko (171566)
- Krznarić, Željko (75865)
- Benković, Jasenka
Proceedings title: 2ND UNITED EUROPEAN GASTROENTEROLOGY WEEK
Language: engleski
Place: BARCELONA, ŠPANJOLSKA
Year: 1993
Pages: from 147 to 0
Meeting: 2ND UNITED EUROPEAN GASTROENTEROLOGY WEEK
Held: from 07/19/93 to 07/24/93
Summary: In order to identify reliable method for predicting relaps
inulcerative colitis, we studied prospectively 57 patients inremission at
the beginning of the study for 8 months period. The
activity of disease was monitored by Powell-Tuck activity indexand by
following laboratory parameters:ESR, fibrinogen,alpha-l-antitrypsin and
alpha-l-glycoprotein. Statisticaldifferences in Powel-Tuck index and
laboratory parameters betweenpatients who remained in remission and those
who relapsed wereevaluated by Student t-test.
Table l and 2 ommited.
Conclusion: ESR, alfa-l-antitrypsin and alfa-l-glycoproteinshowed
predictive value regarding impending relapse. All studiedparameters
increased significantly at time of relapse.Identification of patients in
clinical remission with high riskof relapse using alpha-1-antitrypsin and
alpha-l-glycoproteinmight indicate early treatment.
Keywords: Ulcerative colitis, acute phase proteins, relapse prediction.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Vucelić, Boris (116793)
- Grle, Sanja
- Ostojić, Rajko (171566)
- Krznarić, Željko (75865)
Proceedings title: 2ND UNITED EUROPEAN GASTROENTEROLOGY WEEK
Language: engleski
Place: BARCELONA, ŠPANJOLSKA
Year: 1993
Pages: from 147 to 0
Meeting: 2ND UNITED EUROPEAN GASTROENTEROLOGY WEEK
Held: from 07/19/93 to 07/24/93
Summary: We studied 42 IBD patients (32 with UC and 10 with MC) and
30
control subjects using pulmonary function tests:spirometry,
flow-volume curve, body pletismography and diffusing capacity
for CO by single breath method. Activity of disease was assessed
using Powell-Tuck index in UC and CDAI in MC.
Results: decreased diffusing capacity (65,5% +/- 14,9% ofcontrols) was
found in 11 patients (26%), 6 with UC (all active
with Powell-Tuck 6,4+/-2,7) and 5 with MC (all active with CDAI
238+/-31). All of those patients were taking sulphasalazine
(7,2+/-7 years), none was anemic or having preexistent heart
or lung disease.Nine patients in this group reported exertional
dyspnea. 12 patients had increased residual volume measured by
body pletismography, most of them having decreased expiration
reserve volume and maximal minute ventilation, which mightindicate sceletal
muscle weakness. 10 of those patients were in
remission and only two with UC active.There were no restrictive
abnormalities noted. Among studied population there were 52%
smokers and 14% ex-smokers so that pulmonary function tests
were better than expected with exception of significant number
with decreased pulmonary diffusion.Possible explanations are
interstitial lung disease as extraintestinal complication of IBD
or sulphasalazine-associated alveolitis.Further studies as BAL
and transbronchial biopsies are needed.
Keywords: Pulmonary function tests, inflammatory bowel diseases.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Vucelić, Boris (116793)
- Grle, Sanja
- Ostojić, Rajko (171566)
- Krznarić, Željko (75865)
Proceedings title: IV INTERNATIOANL SYMPOSIUM ON IBD
Language: engleski
Place: STRASBOURG, FRANCE
Year: 1993
Pages: from 181 to 181
Meeting: IV INTERNATIONAL SYMPOSIUM ON IBD
Held: from 09/15/93 to 09/17/93
Summary: We studied 42 IBD patients (32 with UC and 10 with MC) and
30 control subjects using pulmonary function tests: spirometry, flow-volume
curve, body pletismography and diffusing capacity for CO by single breath
method. Activity of disease was assessed using Fowell-Tuck index in UC and
CDAI in MC.
Results: decreased diffusing capacity (65,5% +/- 14,9% of controls) was
found in ll patients (26%), 6 with UC (all active with Powell-Tuck 6,4 +/-
2,7) and 5 with MC (all active with CDAI 238 +/- 31).All of those patients
were taking sulfasalazine(7,2 +/- years), none was anemic or having
preexistent heart of lung disease. Nine patients in this group reported
exertional dispnea.
12 patients (29%) had increased residual volume measured by body
pletismography (198%-71%) of controls most of them having decreased
expiration reserve volume and maximal minute ventilation, which might
indicate sceletal muscle weakness, but peak expiratory flow was normal. Ten
of those patients were in remission and only two with UC active. Possible
explanation might be excesive colon transversum inflation. There were no
restrictive abnormalities noted.
Conclusion:
Among studied population there were 52% smokers and 14% ex-smokers so that
pulmonarz function tests were better than expencted with exception of
significant number with decreased pulmonary diffusion. Possible explanation
for that observation are interstitial lung disease as extraintestinal
complication of IBD or sulfasalazine-associated alveolitis. Further studies
as bronchoalveolar lavage and transbronchial biopsies are needed.
Keywords: pulmonary functiona changes.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Krznarić, Željko (75865)
- Ostojić, Rajko (171566)
- Vucelić, Boris (116793)
- Brkić, Tomislav
- Opačić, Milorad
- Rustemović, Nadan
Proceedings title: FIRST CROATIAN CONGRESS OF GASTROENTEROLOGY
Language: engleski
Place: Zagreb
Year: 1994
Pages: from 46 to 46
Meeting: FIRST CROATIAN CONGRESS OF GASTROENTEROLOGY
Held: from 11/24/94 to 11/26/94
Summary: In order to identify reliable method for predicting
relapse in Crohn's disease, we studied prospectively 53 patients in
remission at the beginning of the study for 2 year period. The activity of
disease was monitored by CDAI and by following laboratory parameters: ESR
(first hour), fibrinogen (normal 1,8-3,5 g/L), alpha-1-antitrypsin (norm.
1,4-3,2 g/L) and orosomucoid (norm. 0,4-1,3 g/L). As statistical method we
used Spearman's rank correlation test.
Our results show that all parameters have statistical significant as
follows:ESR p<0,01, fibrinogen p<0,01, alpha-1-antitrypsin p<0,0l,
orosomucoid p<0,0l.
Conclusion: esr, alpha-l-antitrypsin and orosomucoid showed predictive
value regarding impending relapse. All studied parameters increased
significantly shortly before time of relapse. Identification of patients in
clinical remission with high risk of relapse using alpha-a-antitrypsin and
orosomucoid might indicate early treatment.
Keywords: alpha-a-antitrypsin, alfha-l-antitrypsin.
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Ostojić, Rajko (171566)
- Krznarić, Željko (75865)
- Vucelić, Boris (116793)
- Pulanić, Roland
- Rustemović, Nadan
- Opačić, Milorad
- Brkić, Tomislav
Proceedings title: FIRST CROATIAN CONGRESS OF GASTROENTEROLOGY
Language: engleski
Place: Zagreb
Year: 1994
Pages: from 50 to 50
Meeting: FIRST CROATIAN CONGRESS OF GASTROENTEROLOGY
Held: from 11/24/94 to 11/26/94
Summary: In order to identify reliable method for predicting relapse
in ulcerative colitis, we studied prospectively 70 pts in remission at the
beginning of the study for 2 years period. The activity of disease was
monitored by Powel-Tuck activity index and by following laboratory
parameters:ESR, fibrinogen, alpha-l-antitrypsin and orosomucoid.
Statistical differences in Powel-Tuck index and laboratory parameters
between pts who remained in remission and those who relapsed were evaluated
bz Student t-test.
Our results show that all parameteres have statistical significance as
follows: ESR p<0,0l; fibrinogen p<0,01; alpha-l-antitrypsin p<0,00l;
orosomucoid p<0,001.
Conclusion: All studied parameters increased significantly at time of
relapse. Identification of patients in clinical remission with high risk of
relapse using alpha-l-antitrypsin and orosomucoid might indicate early
treatment.
Keywords: alpha-l-antitrypsin, orosomucoid.
- Type of paper
: Ph.D.
Title:
Faculty: MEDICINSKI FAKULTET SVEUČILIŠTE ZAGREB
Date of defense: 10/10/91
Language: hrvatski
Number of pages: 101
Summary: The selenium in the serum of the healthy population in our
country displays values among the lowest in the world. We used
method of atomic absorption spectrophotometry and sampleconsisted of 202
persons of both sexes (age range from 20
to 80 years) while values were 66,79 +/-9,13 ug/l.
The ulcerose colitis as a disease with increased risk fordevelopment of
colorectal cancer is not associated withhyposelenemia (n=45, Se (s)
66,5+/-14,43 ug/l), while in
Crohn's disease we found a significant decrease /n=25,
Se(s) 62,014,48 p<0,05).
Colorectal adenomas were associated with significanthyposelenemia which was
more pronounced in multiple polyps.
Colorectal carcinoma is associated with significant hyposelenemiawhich is
more pronounced in mucinous type than in adenocarcinoma
and clearly dependant on Dukes stages.
Patients with cirrhosis of the liver had significanthyposelenemia similar
to Dukes D colorectal carcinoma indicating
that proper judgement of serum selenium concentration as the
biochemical marker in colorectal tumors (adenomas and carcinomas)
implies the previous evaluation of hepatal status.
Keywords: Selenium, inflammatory bowel diseases, adenomas, colorectal carcinoma, cirrhosis of the liver.
- Type of paper
: Mentorship
Title:
Faculty: MEDICINSKI FAKULTET SVEUČILIŠTE ZAGREB
Date of defense: 11/10/91
Number of pages: 101
Author: Buljevac dr.med. Mladen
Degree level: Ph.D.
