SVIBOR - Papers - project code: 3-01-372

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Published papers on project 3-01-372


Quoted papers: 2
Other papers: 4
Total: 6
  1. Type of paper: Paper in journal

    Title: PROGNOSTIC VALUE OF B-SYMPTOMS IN LOW-GRADE NON-HODGKIN LYMPHOMAS

    Authors:
    Vučković, Joško (168925)
    Zemunik, Tatijana (202381)
    Forempoher, Gea (185950)
    Knežević, Nebojša
    Štula, Nikola (116194)
    Dubravčić, Mirko
    Čapkun, Vesna
    Journal: LEUKEMIA AND LYMPHOMA
    Number: 3
    ISSN: 1042-8194
    Volume: 13
    Year: 1994
    Pages: from 357 to 358
    Number of references: 9
    Language: engleski
    Summary: The group of 68 patients (age 29-82) with LG-NHL stage II-IV wereobserved in the period 1978-1992. The median observation periodwas 40 months. Fifteen (22) had "B"-symptoms on presentation(unexplained fever, drenching night sweats or loss of more than10% of body weight within a period of 6 months). Patients weretreated initially mainly with the COP protocol and lateraccording to there response with either CHOP or monochemotherapy.The 5-year survival rates for patients with and withoutB-symptoms were 16% and 75% respectively, p=0,01. The resultssupport the view that B-symptoms indicate a poorer prognosis andwe advocate a more aggresive therapeutic approach to such LG-NHLpatients.
    Keywords: Prognostic value, B-symptoms, low grade lymphomas
  2. Type of paper: Paper in journal

    Title: PROGNOSTIC VALUE OF THE LYMPHOCYTE DOUBLING TIME IN THE BLOOD OF PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA STAGES RAI 0 AND 1

    Authors:
    Dubravčić, Mirko
    Vučković, Joško (168925)
    Martinović, Merica
    Knežević, Nebojša
    Zemunik, Tatijana (202381)
    Marinković, Marija
    Štula, Nikola (116194)
    Journal: MEDICINSKI ANALI
    Number: 1
    ISSN: 0352-602
    Volume: 17
    Year: 1991
    Pages: from 5 to 8
    Number of references: 6
    Language: hrvatski
    Summary: In a group of 45 patients with chronic lymphocytic leukemiastages Rai 0 and I (23 males and 22 females, median age 64 years)followed up for more than 12 months we compared lymphocyticdoubling time (LTD) with the expected survival. In 20 pts LDT wasshorter than 24 months and expected survival at 10 years was 24%.In the group of 25 pts with LDT longer than 24 months, theexpected survival at 10 years was 75% The difference issignificant (p less than 0,05)
    Keywords: Chronic lymphocytic leukemia, lymphocyte doubling time, prognosis.
  3. Type of paper: Paper in journal

    Title: Significance of aneuploidy in non-Hodgkin lymphomas

    Authors:
    Vučković, Joško (168925)
    Forempoher, Gea (185950)
    Knežević, Nebojša
    Štula, Nikola (116194)
    Dubravčić, Mirko
    Čapkun, Vesna
    Maru'ić, Matko
    Sabioncello, Ante
    Journal: Journal of Clinical Laboratory Analysis
    ISSN: 0887-8013
    Volume: 9
    Year: 1996
    Pages: from 343 to 346
    Language: engleski
    Summary: Flow cytometric DNA analysis was performed on paraffine embededbiopsy specimens taken of 125 NHL patients (48 low-grade, 77interm.+high grade, 65 women,61 men, age 23-81 median 61). Lowgrade NHL (LG-NHL) were treated initialy with COP or monokemoth.with Leukeran and others (HG-NHL) with CHOP protokol. Thediagnosis of DNA aneuploidy was made only in the presence ofdefinable peak or peaks other than G0/1 in histograms. Aneuploidywas found in 34 out of 125pts (27%) There were no significantdifferences in fraction of aneuploid tumours between histologicaltypes, nor between prognostic groups. Median survival for thewhole group was 44 months and for LG-NHL and for HG-NHL 58 monthsand 25 months respectivly. Generaly aneuploidy did not appear toinfluence the survival. In HG-NHL the median survival for euploidand aneuploid tumours was nearly equal (26 v. 22 months) Howeverin LG-NHL aneuploidy expressed some bordeline influence onsurvival (p=0,056). Tetraploid pattern of aneuploidy was moreoften encounted in LG-NHL (80%) than in HG-NHL(58%) but withoutstatistical significancy. Patern of aneuploidy was not associatedwith advantage in surviva.
    Keywords: Non-Hodgkin lymphomas, flow cytometry, DNA analysis, survival.
  4. Type of paper: Summary in proceedings

    Title: FLOW CYTOMETRIC DNA ANALYSIS OF 125 NON-HODGKIN,S LYMPHOMAS ; A COMPARISON WITH MICRODENSITOMETRIC STUDY
    Proceedings title: ABSTRACTS-FIFTH INTERNATIONAL CONFERENCE ON MALIGNANT LYMPHOMA, LUGANO
    Language: engleski
    Place: LUGANO, SWITZERLAND
    Year: 1993
    Pages: from 120 to 120
    Meeting: FIFTH INTERNATIONAL CONFERENCE ON MALIGNANT LYMPHOMA
    Held: from 06/09/93 to 06/12/93
    Summary: DNA Flow-cytometry was done on paraffine embedded lymph nodestaken before therapy in 125 non-Hodgkin lymphoma (NHL) patients.Frequency of aneuploidy was 27% (34/125). There was nosignificant difference between frequency of aneuploidy inlow-grade NHL, 31%(15/48) and in intermediate+high -grade NHL(HG-NHL) 25% (19/77). In LG-NHL aneuploidy appeared to have anadverse effect on survival (p=0,056-0,08). In HG-NHL as well asin the whole group ploidy status did not influence the survival. Increased proliferative activity measured by flow-cytometry(expressed as S+G2M more than 6% of cells) had adverse effect onsurvival in the whole group. The median survival for the highproliferative group (HP) was 27 months and for low proliferative(LP) it was 72 months (p=0,02). Inside LG-NHL the difference insurvival between HP and LP group was highly significant, while inHG-NHL such difference was not found. Simmilar results regardingproliferative activity and survival were obtained bymicrodensitometric study. Values for S+G2M measured by twomethods showed high degree of correlation, r=0,89 p=0,01.

  5. Type of paper: Mentorship

    Title: PROGNOSTIC PARAMETERS IN LOW GRADE NON-HODGKIN LYMPHOMAS
    Date of defense: 01/14/94
    Number of pages: 75
    Author: Zemunik Dr. Med. Tatijana
    Degree level: M.A.

  6. Type of paper: Mentorship

    Title: PROGNOSTIC PAREAMETERS IN NON-HODGKIN LYMPHOMAS, CORRELATION WITH FLOW-CYTOMETRY DATA
    Faculty: MEDICINSKI FAKULTET U ZAGREBU
    Date of defense: 11/25/94
    Number of pages: 64
    Author: Forempoher Dr.Med Gea
    Degree level: M.A.

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