SVIBOR - Project code: 3-01-372

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-372


PARAMETERS OF PROLIFERATION AND THEIR INFLUENCE ON PROGNOSIS IN NON-HODGKIN LYMPHOMAS


Main researcher: VUČKOVIĆ, JOŠKO (168925)


Assistants
Type of research: applied
Duration from: 04/01/91. to 04/01/95.
Papers on project (total): 6
Papers on project quoted in Current Contents: 2
Institution name: Bolnica "Firule", Split (141)
Communication
Phone: 385 (0)01219988
Summary: In the patients with Non Hodgkin lymphomas the following proliferative parameters will be measured and corelated with routine histological, clinical, and laboratory data: 1. Mitotic index calculated at 10 HPF (High Power Fields) 2. "S" phase and PI (Proliferative Index) using the method of flow cytometry (FC),3. Ploidy status, using the same method, and 4. Fraction of cells with DNA content more than 2N, done with the method of microdensitometry. In the case of Low-Grade lymphomas with leukemic blood picture and KLL doubling time of lymphocytes is calculated and regarded as proliferative parameter.

Keywords: Non-Hodgkin lymphomas, parameters of proliferation, "S"-phase, proliferative index,ploidy, flow-cytometry, mitotic index, microdenzitometry, histology, Kiel-classification, Working formulation, prognostic parameters, clinical stage, "B"-symptoms, LDH, survival.

Research goals: The aim of the work is to measure the parameters of proliferation with different methods and corelate the results. Then we intend to corelate proliferation parameters with clinical, histological and laboratory data and survival. We shall try to settle the value of proliferative parameters in making diagnosis of malignant lymphoma sa well as in predicting complete remision,its duration and overal survival. We expect to find difference in proliferative capacity between different histological types of NHL and significance of difference in proliferative capacity between individual lymphomas of the same histological type. We also intend to corelate proliferative parameters with other prognostic factors and hope to find its significance in multivariante analysis.

COOPERATION - INSTITUTIONS


  1. Name of institution: Laboratorij za imunologiju KBC "Zagreb"
    Type of institution: International organization
    City: 41000 - Zagreb, Croatia
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