SVIBOR - Project code: 3-01-380

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SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-380

HEPATITIS Bs ANTIGEN POSITIVE PREGNANT WOMEN, ACTIVE AND PASSIVE PROTECTION OF THEIR NEWBORNS AND BREAST FEEDING

Main researcher: CAPAR, MARIJAN (110263)

Assistants

KOSIĆ-ANDRAŠEVIĆ, VIKTORIJA (85181)

Type of research: applied
Duration from: 01/01/91. to 12/31/93.

Papers on project (total): 9

Institution name: Medicinski centar - Bolničke djelatnosti, Pula (163)
Department/Institute: Department for pediatrics
Address: Zagrebačka 34, 52000 Pula, Croatia
City: 52000 - Pula, Croatia

Communication: Phone: 385 (0)52-214433; Fax: 385 (0)52-211060

Summary: During the three years period all pregnant women routinely were sreened for hepatitis B surface antigen (HBsAg) in the two counties of Croatia. 15596 pregnant women gave birth to 15558 newborns. Among the pregnant women 133 (0.86%) were HBsAg positive and they gave birth to 134 newborns. 88 out of these 134 newborns were breast-fed (group A) and 46 were bottle-fed (group B). In the maternity ward 86 newborns from group A and 45 from group B received appropriate dose of hepatitis B immunoglobulin (HBIg) and all children were given the first dose of 20 Šg recombinant hepatitis B virus vaccine (rHBV). The second and third doses of rHBV were given one and six months after the first. Two children from group A and one child from group B did not received HBIg, and they were omitted from the follow up. On the first control one month after birth arrived 79/86 (91.9%) children from group A and 41/45 (91.1%) from group B. All these children were HBsAg negative and all but one from group B anti-HBs positive. This child also developed seroconversion so that with 3,6 and 9 months titres of anti-HBs were 4.7 IU/L, 11 IU/L and 68 IU/L. Completely passively and actively vaccinated from group A were 65/86 (75.6%) children and from group B 36/45 (80.0%). In the age of 6 months all of these children were HBsAg negative and anti-HBs positive. On the controles with 9,12 and 18 months came from the group A 56/86 (65.1%), 54/86 (62.8%) and 54/86 (62.8% children) and from group B 31/45 (68.9%), 31/45 (68.9%) and 30/45 (66.7%) children. All of them were HBsAg negative and anti-HBs positive. In the part of the samples from groups A and B it was possible to determine mean geometric titre of anti-HBs which did not significantly differ between both groups. Considerable rise of anti-HBs titer (above 1000 IU/L) was observed after the third dose of rHBV. Vaccination complications were one day's temperature to 38řC and/or transitory redness at the injection site and were observed 12 times (2.56%) on 468 injections. The historic risk factors for the previous infection with hepatitis B virus (HBV) of pregnant women were registered in 38.1% of them. In the examined area the endemicity of HBV infection of pregnant women is low. All pregnant women should be screened for HBV infection until the vaccination with HBV vaccine enters into the scheme of the obligatory vaccination of all newborns. The success of immunisation among the breast-fed and bottle-fed of followed children was the same.

Keywords: hepatitis B,prenatal screening,neonatal immunoprophylaxis,breast feeding

Research goals: To registrate the incidence of hepatitis B-surface antigen (HBsAg) positive pregnant women in the period from 1.1.1991. to 31.12.1993. in defined region of Primorje-Gorski kotar and Istra county; to examine the so called risk factors for possible previous infection of pregnant women with the hepatitis B virus according to recomendations of the Centers for Diseases Control, USA; to conduct passive and active vaccination of newborns of HBsAg positive mothers and registrate the successfulness of vaccination of the breast-fed and bottle-fed children; to registrate the complications of vaccinations.

Other information about the project.


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