SVIBOR - Project code: 3-01-402

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Project code: 3-01-402


PSYCHOLOGICAL,SOCIOLOGICAL AND EPIDEMIC STUDY OF SYSTEMIC CONNECTIVE TISSUE DISEASE


Main researcher: HORVAT, ZVONIMIR (77553)


Assistants
Type of research: applied
Duration from: 10/17/91. to 10/17/94.
Papers on project (total): 44
Papers on project quoted in Current Contents: 5
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of Rheumatology and Immunology, Department of Internal Medicine University Hospital Rebro, School of Medicine University of Zagreb
Address: Kispaticeva 12
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)01 2333-233/330,223-180
Fax: 385 (0)01 223-180
Summary: In patients with autoimmune systemic diseases, systemic lupus erythematosus (SLE) and rheumatoid artrhitis (RA), psychological, sociological and epidemic as well as the other factors are studied. These factors together with traditional way of treatment of patients with autoimmune disease give quite valuable data that may be applied in everyday clinical practice with regard to the course and outcome of the disease, quality of life and clinical and laboratory values that are needed to establish the diagnosis (according to the accepted criteria of the American Rheumatology Association) and assess the activity of the disease, the precise status of cell immunity using two-color flow cytometric analysis for peripheral blood mononuclear cells bearing T, B and NK-cell marker and NK-activity were also studied. The value and reability oflymphatic subpopulation determination of the disease activity and its use in every day clinical practice have been also investigated. Futhermore, in patients in whom organic imparirment of the central nervous system due to the basic disease has been excluded, repeated psychological testing is undertaken. The effectiveness of these phychological as well as psychiatric treatment is evaluated as well. Patients included into this research parallely with psychological and psychiatric treatment are managed by a standard therapy fogether with usual clinical and laboratory control of the disease. Results are analysed by tests of correlation and multivariant analysis.

Keywords: systemic lupus erythematosus, rheumatoid arthritis, imunological psychologial, psychiatrical, sociological, dermographical factors.

Research goals: 1. To analyse the value of the study of psychological, sociological and epidemiologic factors together with clinical, laboratory and immunological parameters in patients with SLE and RA with regard to the occurence, course and outcome of disease. 2. To analyse the differences in clinical and laboratory parameters with respect to the activity of disease, especially, to precisly analyse the changes in the cell and humoral immunity by the introduction of new dignostic methods. 3. To analyse the changes in the results of psychological tests and the value of evaluation of psychological status of patients with SLE and RA outcome of disease. 5. To use a systematic approach in the diagnosis and treatment of autoimmune diseases and to parallely analyse and treat psychosomatic and immunological disorders, respectively. 6. To determine the value of information that co9uld be used in "nonpharmacological interventions during treatment of autoimmune diseases. 7. To promote the quality of life of patients, secondary prevention of disease complications and morbidity. 8. To advance the working ability of patients and decrease the economic consequens due to long-term disease.

COOPERATION - PROJECTS


  1. Name of project: Multicentric study of SLE patients with disease duration > 10 years (Eular)
    Name of institution: Departement of rheumatology, Dr. Daniel Den Hoed Kliniek,Gooene Hilledijk 301
    City: Rotterdam, Neherlands

COOPERATION - INSTITUTIONS


  1. Name of institution: ZAVOD ZA FIZIKALNU MEDICINU I REHABILITACIJU,KBC,REBRO
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of information
    City: 10000 - Zagreb, Croatia

  2. Name of institution: CENTAR ZA MENTALNO ZDRAVLJE, KBC, REBRO
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of information
    City: 10000 - Zagreb, Croatia

  3. Name of institution: DEPARTMENT OF RHEUMATOLOGY DR. DANIEL DEN HOED KLINIEK
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of information
    City: Rotterdam, Neherlands
Other information about the project.
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Last update: 10/27/95
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