SVIBOR - Papers quoted in CC - project code: 3-01-412

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Papers quoted in Current Contents on project 3-01-412

Quoted papers: 8
Other papers: 1
Total: 9

Title:

Authors:: Jonjić, Nives (84573); Alberti, Saverio; Bernasconi, Sergio; Peri, Giuseppe; Petr, Jilek; Anichini, Andrea; Parmiani, Giorgio; Mantovani, Alberto

Journal: Eur. J. Immunol.
ISSN: 2255-2260
Volume: 22
Year: 1992
Pages: from 2255 to 2260
Number of references: 48
Language: engleski
Summary: Five clones derived from the same human malignant melanoma lesionwere stuied for their susceptibility to killing by humanmonocytes activated by exposure to interferon (IFN)-gamma andlipopolysaccharide. Melanoma clones were heterogeneous in theirsusceptibility to human monocyte cytotoxicity with one clone(2/21) exhibiting extremely low lwvels of lysis. The differentlevels of susceptibility to monocyte cytotoxicity were notaccounted for by susceptibility or resistance to monokines tumornecrosis factor (TNF) interelukin (IL)-1 and IL-6 because: (a)these effector molecules had little (TNF) or no (IL-1 and IL-6)cytolytic activity under these conditions: and (b) anti-TNFantibodies had marginal effects on cytotoxicity. Monocytes boundless to resistant than to susceeptible melanoma cells.Monocyte-resistant 2/21 melanoma cells expressed substantiallylower levels of ICAM-1 and VLA-4 than susceptible cells.Anti-cD18 and, to a lesser extent, anti-ICAM-1 mAb inhibitedbinding and cytotoxicity of human monocytes on malignant melanomawhereas anti VLA-4 had no inhibitory action. Transfection of theICAM-1 gene undr the control of a constitutive promotor resultedin high levels of expression of ICAM-1 in 2/21 melanoma cellsand, concomitantly, in augmented susceptibility to activatedmonocyte cytotoxicity. The augmented killing of ICAM-1transfected 2/21 cells was inhibited by anti-ICAM-1 mAb. Theseresults demonstrate that the CD18-ICAM-1 adhesion pathway canplay an important role in the expression of human monocytecytotoxicity on melanoma target cells and that heterogencity inexpression of ICAM-1 can underlie differences in susceptibilityto tumoricidal activity.

Title:

Authors:: Lučin, Ksenija; Jonjić, Nives (84573); Iternička, Zlatko

Journal: Path Res Pract
ISSN: 0344-0338
Volume: 190
Year: 1994
Pages: from 1134 to 1140
Number of references: 35
Language: engleski
Summary: In this studz immunohistological staining was used to assess the presence of T cell infiltrates and the expression of beta2 microglobulin and HLADR antigens on tumor cells of 75 ductal invasive carcinomas. The results were compared with the morphometric prognostic index (MPI) that seems to be the most accurate prognostic predictor.The extent of T cell infiltrates differed widelx between tumors, but statisticallz significant correlation was found onlz with the lzmph node status, namelz tumors with a high degree of infiltration had predominantlz negative lzmph nodes and vice versa (pĐ0.05). Onlz 19 (25.3%) out of 75 carcinomas were beta2 m+, 34 cases (45.3%) showed heterogenous staining pattern and 22 tumors (29.3%) were completelz negative. We could not find anz significant correlation between beta2m expression and MPI or T cell cintent. While normal breast epithelium was alwazs HLA/DR negative, tumor cells displazed positivitz in 25 cases (33.3%), 5 tumors (6.7%) were completelz positive and 20 tumors (26.7%) displazed onlz focal expression of class II antigens. This expression did not correlate with anz single prognostic paremeters, nor with MPI. The results suggest that T cell infiltrates and the expression of histocompatibilitz antigens can not be accepted as prognostic indicators in breast carcinom.
Keywords: T lzmphocztes, Histocompatibilitz antigens, Breast carcinoma, Morphometric prognostic index


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