SVIBOR - Project code: 3-01-412


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Project code: 3-01-412

Immunological mechanisms in control of tumor growth

Main researcher: JONJIĈ, NIVES (84573)

Type of research: basic
Duration from: 01/01/92. to 01/01/96.

Papers on project (total): 9
Papers on project quoted in Current Contents: 8
Institution name: Medicinski fakultet, Rijeka (62)
Department/Institute: Department of patology
Address: Braĉe Branchetta 20
City: 51000 - Rijeka, Croatia

Summary: In the first part of our study, the effect of T cell subset depletion on the growth of primary tumor graft as well as the ability of tumor-primed mice to reject the secondary tumor challenge was tested. In the initial phase of the primary tumor growth, both T cell subsets are required for the control of tumor growth, while in the later phase only CD8+ cells are essential. Postexcision immunity was tested as the ability of mice toreject the secondary tumor graft of the same tumor. Primed, nondepleted mice were resistant to secondary tumor graft. Depletion of either CD4+ or CD8+ T lymphocytes abolished the resistance, with more pronounced effect in anti CD8 treated mice. In this project the immunohistological staining was used to asses the presence of T cell infiltrates and expression of beta 2 - microglobuline and HLA DR antigens on tumor cells of ductal invasive carcinomas.The results were compared with themorphometric prognostic index (MPI) that seems to be the most accurate prognostic predictor. The extent of T cell infiltrates differed widely between tumors, but statistically significant correlation was found only with lymph node status. The expression of beta 2 - microglobuline and HLA DR antigens did not correlate with any single prognostic parameter, nor with MPI. The cellular receptor proteins mediating adhesive events are important in tumor invasion and metastasis. In our study wetested the expression of beta 1 - integrin molecules on the tumor cellsof infiltrating ductal carcinoma. The results show that theexpression of this molecules are heterogenous in the tumors. Low or absent expression of beta 1 - integrins correlated with tumors exceeding 2 cm and with positive lymph nodes. This results support theidea that loss of beta - 1 integrins correlates with the invasive and metastatic potential of tumor cells.

Keywords: tumors, lymphocytes T, adhesion molecules.

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Last update: 11/08/95