SVIBOR - Project code: 3-01-418

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-418


STUDY OF TRAUMATIC BRAIN INJURIES TISSUE SPECIMEN CHARACTERISTICS


Main researcher: JADRO-ŠANTEL, DUBRAVKA (17611)


Assistants
Type of research: basic
Duration from: 09/01/91. to 12/31/95.
Papers on project (total): 24
Papers on project quoted in Current Contents: 6
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of Neuropathology University Hospital Rebro
Address: Kišpatićeva 12
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)41 222 706
Fax: 385 (0)41 222 706
Phone: 385 (0)41 233 233 / 363
Summary: The investigation is a continuation of a long-term study of the closed brain injury of acceleration-deceleration type. The investigation has established the concept of "innercerebral trauma", i.e. the regularity of the occurrence of itspattern. Most of the so far accomplished and published investigations were related to correlation of histological and tissue characteristics of traumatic brain lesions with radiological findings obtained on CT scans of traumatized brain and head. A group of subjects who had suffered open head injury during the war in Croatia was also included in the investigation. This investigation results are published. We are now working the neuropathological analysis of large hemispheral cuts through the brain of traumatized patients who died at various intervals after brain trauma. Our hypothesis is that the axonal traumatic lesions are not diffuse but focal. The investigation on the possibilities for better visualization of middle part of temporal lobe (hippocampus) still goes on and results will be published. Morphological changes visualized by CT will be correlated with EEG findings and psychological testing.

Keywords: closed brain injury, acceleration brain injury, "inner cerebral trauma", neuropathology, neuroradiology, epidemiology, "diffuse axonal injury", clinical consequnces of brain injury

Research goals: In correlative investigations (neuropathological examinations andcomputed tomography) CT characteristics of traumatic lesions inthe brain were determined. That result is now widely accepted inworld's literature as a concept of "living pathology" (Grčević).By investigations on silver impregnated hemispheral cuts oftraumatized brains, we intend to determine a pattern (foci) ofaxonal "balls", which develop from the first till about 70th daysafter the formation of traumatized focus. We expect that thetraumatic axonal lesions are focal and not diffuse what issometimes believed. With modified technique of CT scanning, with25 degrees oblique cuts, medial structures of temporal lobe areexpected to be visualized more accurately. We expect those CTscans to be of bigger quality, avoiding otherwise existingartifacts due to adjacent bone and connective tissue which makevisualization of traumatic lesions in that brain region(hippocampus) quite difficult and inaccurate. Obtained results from CT investigation will be correlated with EEG findings and psychologic profile. Early sequele in brain parenchyma after the brain trauma will be investigated using the CT.
Other information about the project.
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Last update: 10/05/95
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