DENERVATION HYPERSENSITIVITY OF AUTONOMIC NERVOUS SYSTEM
Main researcher
: ZURAK, NIKŠA (55286) Assistants
ŠOŠTARKO, MARIJA (47890)
SALZER, BRANKA (42223)
HERAK-KRAMBERGER, CAROL MIRNA (149081)
BINGULAC-POPOVIĆ, JASNA (177071)
ŠRENGER, VESNA (124871)
FRANJIĆ, JASNA (33462)
BRINAR, VESNA (34860)
Type of research: applied Duration from: 10/01/91. to 10/01/95. Papers on project (total): 67
Papers on project quoted in Current Contents: 1
Institution name: Medicinski fakultet, Zagreb (108) Department/Institute: Department of Neurology, KBC Rebro, Laboratory for investigating vegetative nervous system and cognitive functions Address: Kišpatićeva 12 City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)1-2335-595
Fax: 385 (0)1-2335-595
Summary: Denervation hypersensitivity is an increased reaction of an
organ to neurotransmitters or their agonists, after their neural junction
has been broken by an organic damage, that is by functional or
pharmacological block. The aim of investigation is, by means of exact
methods of functional investigation, to determine the type of dysfunction
and the aberration direction of the autonomic nervous system (ANS)
functions in diseases with the assumed mechanism of denervation
hypersensitivity, that is with functional and organic dysfunction of this
system. The following research methods will be applied: tests of autonomic
cardiovascular functions, native and activated computerized color
telethermography (CCTT), and determination of autonomic neurotransmitter
receptors in the lymphocytes and platelets of the peripheral blood.
Keywords: denervation hypersensitivity of autonomic nervous system (DH ANS), tests of autonomic cardiovascular functions, computerized color telethermography (CCTT), autonomic neurotransmitter receptors
Research goals: The goal of investigation is to determine objective
criteria for diagnosis of DH ANS. In the study will be included patients
with essential arterial hypertension, diabetic and toxic alcoholic
polyneuropathy, Raynaud's syndrome of different cause and patients with
multiple sclerosis. The aim of study is to define the type of dysfunction
and the aberration of ANS functions in diseases with assumed mechanism of
DH ANS. Expected positive results will be used to plan pharmacotherapeutic
strategy in these diseases. Other information about the project.