SVIBOR - Project code: 3-01-424

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-424


DENERVATION HYPERSENSITIVITY OF AUTONOMIC NERVOUS SYSTEM


Main researcher: ZURAK, NIKŠA (55286)



Assistants
Type of research: applied
Duration from: 10/01/91. to 10/01/95.

Papers on project (total): 67
Papers on project quoted in Current Contents: 1
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of Neurology, KBC Rebro, Laboratory for investigating vegetative nervous system and cognitive functions
Address: Kišpatićeva 12
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)1-2335-595
Fax: 385 (0)1-2335-595

Summary: Denervation hypersensitivity is an increased reaction of an organ to neurotransmitters or their agonists, after their neural junction has been broken by an organic damage, that is by functional or pharmacological block. The aim of investigation is, by means of exact methods of functional investigation, to determine the type of dysfunction and the aberration direction of the autonomic nervous system (ANS) functions in diseases with the assumed mechanism of denervation hypersensitivity, that is with functional and organic dysfunction of this system. The following research methods will be applied: tests of autonomic cardiovascular functions, native and activated computerized color telethermography (CCTT), and determination of autonomic neurotransmitter receptors in the lymphocytes and platelets of the peripheral blood.

Keywords: denervation hypersensitivity of autonomic nervous system (DH ANS), tests of autonomic cardiovascular functions, computerized color telethermography (CCTT), autonomic neurotransmitter receptors

Research goals: The goal of investigation is to determine objective criteria for diagnosis of DH ANS. In the study will be included patients with essential arterial hypertension, diabetic and toxic alcoholic polyneuropathy, Raynaud's syndrome of different cause and patients with multiple sclerosis. The aim of study is to define the type of dysfunction and the aberration of ANS functions in diseases with assumed mechanism of DH ANS. Expected positive results will be used to plan pharmacotherapeutic strategy in these diseases.

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Last update: 10/09/95
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