SVIBOR - Project code: 3-01-435

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-435


BIOLOGICAL MARKERS IN DIAGNOSIS AND THERAPY OF PITUITARY ADENOMAS


Main researcher: VIZNER, BRANKA (52590)



Assistants
Type of research: applied
Duration from: 10/11/91. to 12/31/93.

Papers on project (total): 0
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of endocrinology,diabetes and diseases of methabolism Center for clinical neuroendocrinology and pituitary diseases
Address: KB "Sestre milosrdnice", Vinogradska cesta 29
City: 10000 - Zagreb, Croatia
Communication

Summary: Although the functioning pituitary adenomas have specific hormonal markers, their diagnosis and therapeutic aspects are still unclear. The diagnosis and evaluation of nonfunctioning adenomas are more difficult because lack of hormone hypersecretion. Recent investigations suggest some biological supstances as possible markers for these tumors. The most of adenomas show invasive growth that is not completely understood. Thus, we continue: investigations in diagnosis and therapy of functioning pituitary adenomas critical evaluation of diagnostic tests, correlation between clinical data and neurosurgical, histological and immunohistochemical parameters); investigation of "functional" nature in nonfunctioning adenomas (free subunits of glycoprotein hormones, chromogranin);analysis of reccurent pituitary adenomas (growth factors).

Keywords: pituitary adenomas, hormone production, tumor markers, growth factors, immunohistochemistry

Research goals: Despite the considerable advances in diagnosis of pituitary adenomas, methods for assesment their function in vivo are still not enough sensitive and selective. Also are unclear the mechanisms of tumor proliferation. The aims of this investigations are: critical revision and rationalization of diagnostic tests; identification of functional cell types in "nonfunctioning" pituitary adenomas; developement of methods for identification tumor markers (in vivo and in vitro) for their early diagnosis (measurement of chromogranin, alpha and beta subunits): analysis of plurihormonal pituitary adenomas; analysis of growth factors and reccurent pituitary adenomas.

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