BIOLOGICAL MARKERS IN DIAGNOSIS AND THERAPY OF PITUITARY ADENOMAS
Main researcher
: VIZNER, BRANKA (52590) Assistants
LAZIĆ, NEBOJŠA (6091)
SEKSO, MLADEN (42706)
GNJIDIĆ, ŽIVKO (141111)
REŠETIĆ, JOSIP (90136)
BELICZA, MLADEN (2985)
LAMBAŠA, SMILJKA (184436)
RIŽNAR-REŠETIĆ, VESNA (191221)
ORLIĆ-ČUNOVIĆ, DUBRAVKA (141473)
VILIBIĆ, TATJANA (184484)
SMIRČIĆ-DUVNJAK, LEA (171570)
Type of research: applied Duration from: 10/11/91. to 12/31/93. Papers on project (total): 0
Institution name: Medicinski fakultet, Zagreb (108) Department/Institute: Department of endocrinology,diabetes and diseases of methabolism Center for clinical neuroendocrinology and pituitary diseases Address: KB "Sestre milosrdnice", Vinogradska cesta 29 City: 10000 - Zagreb, Croatia
Communication
Summary: Although the functioning pituitary adenomas have specific
hormonal markers, their diagnosis and therapeutic aspects are still
unclear. The diagnosis and evaluation of nonfunctioning adenomas are more
difficult because lack of hormone hypersecretion. Recent investigations
suggest some biological supstances as possible markers for these tumors.
The most of adenomas show invasive growth that is not completely
understood. Thus, we continue: investigations in diagnosis and therapy of
functioning pituitary adenomas critical evaluation of diagnostic tests,
correlation between clinical data and neurosurgical, histological and
immunohistochemical parameters); investigation of "functional" nature in
nonfunctioning adenomas (free subunits of glycoprotein hormones,
chromogranin);analysis of reccurent pituitary adenomas (growth factors).
Research goals: Despite the considerable advances in diagnosis of
pituitary adenomas, methods for assesment their function in vivo are still
not enough sensitive and selective. Also are unclear the mechanisms of
tumor proliferation. The aims of this investigations are: critical revision
and rationalization of diagnostic tests; identification of functional cell
types in "nonfunctioning" pituitary adenomas; developement of methods for
identification tumor markers (in vivo and in vitro) for their early
diagnosis (measurement of chromogranin, alpha and beta subunits): analysis
of plurihormonal pituitary adenomas; analysis of growth factors and
reccurent pituitary adenomas. Other information about the project.