SVIBOR - Project code: 3-03-311

MINISTRY OF SCIENCE AND TECHNOLOGY

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Project code: 3-03-311


Immunology of actual animal myxo-, herpes- and retroviruses


Main researcher: CVETNIĆ, SLAVKO (7325)


Assistants
Type of research: applied
Duration from: 12/27/90. to 12/27/94.
Papers on project (total): 123
Papers on project quoted in Current Contents: 9
Institution name: Veterinarski fakultet, Zagreb (53)
Department/Institute: Department of Microbiology and Infectious Diseases
Address: Heinzelova 55
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 01/2390-206
Fax: 385 01/214-697
Summary: Influenza in horses, swine influenza, infectious bovinerhinotracheitis, parainfluenza 3 infection, bovine leukosis,pseudorabies, equine infectious anemia and equinerhinopneumonitis are diseases permanently present in animalpopulations. Some of them - pseudorabies and parainfluenza 3infection - are present in many animal species. It is necesarypermanently serologically investigate their dynamics, amongstother because of possible antigenic drifts (equine infulenzaviruses). On the basis of the serological results correspondingpreventive measures may be proposed. The efficacy of attenuated and inactivated vaccines against Aujeszky's disease in pigs, infectious bovine rhinotracheitis, equine influenza and Newcastle disease were investigated. Pure antigenic preparations were used for diagnostic and immunopreventive purposes.

Keywords: myxoviruses, herpesviruses, retroviruses, animals, immunology, vaccines, diagnostic tests

Research goals: The goal of this project at the first stage is to determine theprevalence of antibodies to equine and swine influenza viruses,to bovine, equine and suid herpesvirus 1, equine infectiousanemia and bovine leukosis virus, and parainfluenza 3 virus insera of host animal. Then, to isolate and collect the virusstrains. At the second stage to analyse the biologicalcharacteristics of isolated strains. Further, to produce purifiedantigens for the use in different diagnostic tests, and to makeefficacious vaccines against mentioned diseases. The efficacy ofproduced vaccines will be evaluated by challenge infection ofvaccinated animals.

COOPERATION - INSTITUTIONS


  1. Name of institution: Institut Ruđer Bošković
    Type of institution: State institute
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  2. Name of institution: PLIVA, Istraživački institut
    Type of institution: Economical/Production
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  3. Name of institution: Central Veterinary Institut
    Type of institution: State institute
    Type of cooperation: Joint publishing of scientific papers
    City: Lelystad, Nizozemska

OTHER ACHIEVEMENTS


  1. Name: DIPLOMA na 16. izložbi izuma, tehničkih unapređenja i noviteta INOVA '88 Zagreb, 1988. godine i ZLATNA PLAKETA na MAKINOVI '90, Skopje, 1990 god. za rad Inovirana vakcina svinjske kuge
    Type of achievement: Technology
    Authors: Čajavec, S., LJ. Markuš-Cizelj, I. Režić, N. Mašić, A. Pospišil

  2. Name: Posebno priznanje (GRAND PRIX) za uspješan nastup Istraživačkog instituta PLIVE na prvoj hrvatskoj izložbiINOVA'92, Zagreb, 1992. i ZLATNA MEDALJA EUREKA '92, Bruxelles, 1992. za rad Developpment de vaccins contre la maladie d'Aujeszky chez les porcs.
    Type of achievement: Technology
    Authors: Čajavec, S., LJ. Markuš-Cizelj, D. Janić, V. Rukavina, M. Lojkić, S. Cvetnić

  3. Name: ZLATNA PLAKETA za inovaciju: Nova vakcina Marekove bolesti (MARIKAL SPF). INOVA '93, Zagreb
    Type of achievement: Technology
    Authors: Čajavec, S., H. Mazija, Đ. Nemarnik, I. Režić
Other information about the project.
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