SVIBOR - Papers quoted in CC - project code: 3-03-314

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Papers quoted in Current Contents on project 3-03-314

Quoted papers: 7
Other papers: 16
Total: 23

Title: Hepatoprotective effect of BPC-157, a 15-aminoacid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin.

Authors:: Sikirić, Predrag (117454); Seiwerth, Sven (149676); Grabarević, Željko (14604); Ručman, Rudolf; Petek, Marijan (67993); Rotkvić, Ivo (127672); Turković, Branko (55593); Jagić, Vjekoslav (101645); Mildner, Boris (43404); Duvnjak, Marko (138233); Danilović, Žarko (8925); Kolega, Marko (197216); Salamon, Davor; Đačić, Sanja (177464); Dodig, Milan (178511); Lang, Nada (54151); Šeparović, Jadranka; Čorić, Vedran (178592); Šimičević, Velimir (178660); Bulić, Krešimir; Veljača, Marija; Skroza, Nevena; Banić, Marko (164816); Brkić, Tomislav (136556); Buljat, Gojko (38583); Miše, Stjepan (102751); Lučinger, Dražen (178544); Bura, Miljenko (171342)

Journal: Life Sciences
Number: 18
ISSN: 0024-3205
Volume: 53
Year: 1993
Pages: from 291 to 296
Number of references: 20
Language: engleski
Summary: The hepatoprotective effects of a newly synthesised 15 amino acidfragment code named BPC 157 was evaluated in comparison with thereference standards (bromocriptine, amantadine and somatostatin)in varous experimental models of liver injury in rats: 24 h1bileduct + hepatic artery ligation, 48 h-restraint stress and CCl4administration. BPC 157 administered either intragastricallyor intraperitoneally, significantly prevented the development ofliver necrosis or fatty changes in rats subjected to 24 h bileduct + hepatic artery ligation, 48 h-restraint stress, CCl4treatment (1 ml/kg i. p., sacrifice 48 h thereafter). The otherreference drugs had either little or no protective actions inthese models. Noteworthy, the laboratory test results forbilirubin, SGOT, SGPT fully correlated with themacro/microscopical findings. Thus, on the basis of consistentprotective effect of BPC 157, possible clinical application inliver diseases is now warranted.
Keywords: BPC 157, hepatoprotection, dopamine agonists, somatostatine

Title: Stress Induced Gizzard Erosions in Chicks. I. Gross and Histopathological Findings

Authors:: Grabarević, Željko (14604); Tišljar, Marina (130726); Džaja, Petar (188481); Artuković, Branka (139800); Artuković, Branka (139800); Seiwerth, Sven (149676); Sikirić, Predrag (117454)

Journal: Journal of Veterinary Medicine A
Number: 4
ISSN: 0931-184
Volume: 40
Year: 1993
Pages: from 265 to 270
Number of references: 23
Language: engleski
Summary: A model of stress induced gizzard erosions is described. Threedays old chickens were deprived of food for 24 h, and after thatthey were immersed in tap wather (17oC) for five seconds. Group Awas sacrificed immediately before being subjected to stress,group B one hour, group C two hours and group D three hours afterwater immersion stress. Each group consisted of 10 animals.Gizzard lesions in group A were very mild and the main featurewas discoloration of the gizzard lining. In groups B, C and D thelesions were more severe and they were characterised by gizzarderosions, ulcerations and hemorrhages especially pronounced ingroup D. This model produced lesions in all stressed animals.
Keywords: stress, gizzard erosions in chicks, experimental model

Title: Pentagastrin Cytoprotection in Ethanol-Induced Gastric Mucosal Lesions in Rats.

Authors:: Dodig, Milan (178511); Rotkvić, Ivo (127672); Grabarević, Željko (14604); Sikirić, Predrag (117454); Drahotusky, Tanja; Drahotusky, Tanja; Erceg, Damir (177486); Erceg, Damir (177486); Đačić, Sanja (177464); Seiwerth, Sven (149676)

Journal: Journal of Veterinary Medicine A
Number: 7
ISSN: 0931-184
Volume: 40
Year: 1993
Pages: from 509 to 515
Number of references: 22
Language: engleski
Summary: To establish pentagastrin cytoprotection, the effectiveness ofvarious doses of pentagastrin on ethanol induced gastric mucosallesions was investigated in Wistar rats. Significant protectionwas obtainede only after parenteral pretreatment with theexception of the lowest dose (1 microgram/kg. b.w.). Pentagastrincytoprotection is not mediated either by a dopamine, muscarinicor gastrin/CCK receptor or by prostaglandin synthesis. However,the protective effect of pentagastrin is abolished by priorvagotomy, although this procedure alone or sham operation isineffective to influencing control-ethanol lesions. In secretorystudies pentagastrin increased both the volume of gastric juiceand total acid output. Unlike cytoprotection, these were reversedby vagotomy, but also with atropine and proglumide, whereasdomperidone and indomethacin were ineffective.
Keywords: Pentagastrine cytoprotection, ethanol induced lesions, stomach, rats

Title: A Model of Inflammatory Bowel Disease Induced by 2,4-Dinitrofluorbenzene in Previously Sensitized BALB-c Mice

Authors:: Brkić, Tomislav (136556); Banić, Marko (164816); Anić, Branimir (140514); Grabarević, Željko (14604); Rotkvić, Ivo (127672); Artuković, Branka (139800); Duvnjak, Marko (138233); Sikirić, Predrag (117454); Troskot, Branko (117465); Hernandez, Danijel

Journal: Scandinavian Journal of Gastroenterology
ISSN: 0036-5521
Volume: 27
Year: 1992
Pages: from 184 to 188
Number of references: 20
Language: engleski
Summary: The aim of this study was to develop a model of inflammatorybowel disease (IBD) induced by colonic application of2,4-dinitrofluorbenzene in previously sensitized BALB-c mice.During the follow-up period of 30 days we observed ulcerations,haemorrhage, necroses, and mononuclear infiltration in thecolonic mucosa of previously sensitized (experimental) and, to alesser extent, nonsensitized (control) animals. In addition, theanimals in the experimental group developed adhesions, thickeningof colonic segments, stenosis, and dilatation of the colon, andsome animals also developed megacolon. Oedema, mononuclearinfiltration, and superfitial ulcerations were observed in theileum of experimental enimals and, to a lesser extent, in thecontrol group. In addition, the animals in the experimental groupdeveloped extraintestinal changes in the liver and spleen (thatis, pericholangitis and lymphofollicular proliferation). Wesuggest that this model of IBD may have some value for the studyof early pathogenetic mechanisms of IBD and for developing newtherapeutic modalities for this condition.
Keywords: BALB-c mice; 2,4-dinitrofluorbenzene; inflammatory bowel disease, experimental model; inflammatory bowel disease, immunopathogenesis

Title: Effect of methylprednisolone on small bowel, spleen and liver lesions in a murine model of inflammatory bowel disease.

Authors:: Banić, Marko (164816); Brkić, Tomislav (136556); Anić, Branimir (140514); Rotkvić, Ivo (127672); Grabarević, Željko (14604); Duvnjak, Marko (138233); Troskot, Branko (117465); Mihatov, Šime

Journal: Alimentary pharmacology and therapeutics (Oxford)
ISSN: 0269-2813
Volume: 7
Year: 1993
Pages: from 201 to 206
Number of references: 18
Language: engleski
Summary: The aim of this study was to evaluate the influence ofmethylprednisolone (1 mg/kg i.p.) on inflammatory lesions in thesmall bowel, liver (pericholangitis) and spleen (lymphofollicularproliferation), in a model of inflammatory bowel disease inducedby 2,4-dinitrofluorbenzene in previously sensitized BALB-c mice.As a parameter of corticosteroid antiinflammatory andimmunosuppressive action, we simultaneously investigated itseffects on menonuclear cell accumulation within the ileal laminapropria and submucosa during the observed time period (1-30days). We noted a significant decrease in accumulation ofmononuclear cells within the lamina propria (P<0.001). An effecton mononuclear cell infiltration within the ileal submucosa wasalso noted but was not statistically significant. In addition,pericholangitis in the liver and lymphofollicular proliferationin the spleen were not observed in the experimental group duringtreatment with methylprednisolone. The results of this studyindicate that the previously described model of intestinalinflammation could be used in further research of present and newtherapeutic modalities for inflammatory bowel disease.
Keywords: methylprednisolone; inflammatory bowel disease; 2,4-dinitrofluorbenzene; small bowel, liver and spleen changes

Title: The beneficial effect of BPC157, a 15 aminoacid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides.

Authors:: Sikirić, Predrag (117454); Seiwerth, Sven (149676); Grabarević, Željko (14604); Petek, Marijan (67993); Ručman, Rudolf; Turković, Branko (55593); Rotkvić, Ivo (127672); Jagić, Vjekoslav (101645); Duvnjak, Marko (138233); Miše, Stjepan (102751); Đačić, Sanja (177464); Šeparović, Jadranka; Veljača, Marija; Banić, Marko (164816); Brkić, Tomislav (136556)

Journal: Life Sciences
Number: 5
ISSN: 0024-3205
Volume: 54
Year: 1993
Pages: from 63 to 68
Number of references: 20
Language: engleski
Summary: The protection of stomach and duodenum in conjecture with anti-inflammatory effect was demonstrated for anoivel 15 aminoacid peptide, coded BPC157, a fragment of the recently discovered gastric juice peptide BPC. BPC157 (i.p./i.g.)was investigated in rats in comparison with several reference standards in three experimental ulcer models (48h restraint stress, subcutaneous cysteamine, intragastrical 96% ethanol ulcer tests) (pre-/co-/post-treatment). Only BPC157 regimens were consistently effective in all of the tested models. On the other hand, bromocriptine, amantadine, famotidine, cimetidine and somatostatin were ineffective (restraint stress). A dose-dependent protection (cysteamine) and/or partial positive effect (related to treatment conditions) (ethanol), was obtained with glucagon, NPY and secretin whereas CCK (26-30)was not effective. Based on Monastral blue studies BPC157 beneficial effect appears to be related to a strong endothelial protection.
Keywords: BPC157, restraint stress, cysteamine, ethanol, dopamine, CCK, H2 antagonists, somatostatin, NPY, rats

Title: The significance of the gastroprotective effect of body protection compound (BPC): modulation by different procedures

Authors:: Sikirić, Predrag (117454); Petek, Marijan (67993); Ručman, Rudolf; Seiwerth, Sven (149676); Grabarević, Željko (14604); Rotkvić, Ivo (127672); Jagić, Vjekoslav (101645); Turković, Branko (55593); Mildner, Boris (43404); Duvnjak, Marko (138233); Kolega, Marko (197216); Dodig, Milan (178511); Đačić, Sanja (177464); Lučinger, Dražen (178544); Mikulandra, Simon (178645); Erceg, Damir (177486)

Journal: Acta Physiologica Hungarica
Number: 1-4
Volume: 80
Year: 1992
Pages: from 89 to 98
Number of references: 43
Language: engleski
Summary: To elucidate any mechanism of a body protecting effect the observed effects should be investigated also by the way of their modulations induced by ablations of particular organs. For Body Protection Compound (BPC), a newly partially characterised gastric juice peptide, the gastroprotection has largely been studied in basal and modified conditions of 48 h-restraint stress. Ablations or Sham operations have been performed before restraint as follows: 60min vagotomy, 24h ovaria, testes, spleen, 48h medulla of adrenal glands, 40 days thyroparathyroidectomy. BPC (10micrograms/kg) or saline (5ml/kg) have been regularly applied after surgery, 1 h before restraint, intraperitoneally. The group subjected to tyroparathyroidectomy received also once-daily BPC/saline treatment. A very strong gstroprotective effect in basal conditions has been modulated by ovariectomy and demedullation (abolishment), thyroparathyroidectomy (decrease), and no change occured in case of vagotomy, splenectomy or orchidectomy. Sham operated rats did not differ from corresponding controls. Thus, seeing from point of wiev a wide range of organoprotective effects of BPC (intestinum, kidney, liver, pancreas, inflammation, diabetes mellitus, delayed hypersenitivity), the gastroprotection has been supposed a)to be of crucial pattern in the general concept of organoprotection and b) to be responsible for the mediation of the suggested "stomach stress organoprotective response". Therefore, the obtained modulations suggest a complex and specifical, sex-related action of the overall beneficial effects of BPC.
Keywords: BPC, stomach stress coping response, organ ablations, modulations, gastroprotection, rats


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