SVIBOR - Project code: 3-03-314

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-03-314


THE USE OF DOPAMINE AGONISTS IN VETERINARY MEDICINE


Main researcher: GRABAREVIĆ, ŽELJKO (14604)


Assistants
Type of research: applied
Duration from: 03/01/91. to 12/31/93.
Papers on project (total): 23
Papers on project quoted in Current Contents: 7
Institution name: Veterinarski fakultet, Zagreb (53)
Department/Institute: Department of General Pathology and Pathological Morphology
Address: Heinzelova 55
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)1 2390-313
Fax: 385 (0)1 214-697
Summary: During last five years (1991-1995) studies on effects of dopamine drugs in various indications were conducted. Laboratory animals (mice, rats) and chicks were used. Diseases caused or exarcebated by stress as well as pathological changes in chicks provoked by Trichothecene mycotoxins were studied and described. Couple of new experimental models of diseases were described i.e. inflammatory bowel disease and stress induced gizzard erosions in chickens. In both models, the protective effects of dopamine agonists and negative effects of dopamine antagonists were proven. Major research was conducted concerning the establishment of conections between the dopamine system and newly isolated gastrointestinal peptide (BPC). Effects of dopamine drugs were also investigated in indications such as stress gastric erosions and pancreatic and hepatic lesions during immobilisation stress (restraint stress). The resulty of investigations were published in 14 journal articles, two Phd thesis and two M.S. works.

Keywords: dopamine drugs, veterinary medicine, laboratory animals, chicks, stress induced lesions, inflammatory bowel disease, trichothecene mycotoxins, BPC, gizzard erosions in chicks

Research goals: In this study we want to establish effects of dopamine drugs on stomach, hepatic, intestinal and pancreatic lesions which are of relatively specific aethiology. It is primarly related on the stress induced lesions, tissue lesions caused by trichothene mycotoxins and inflammatory bowel disease. Very scrupulous and exact scientiffic verification of protection or even therapy of this diseases would enable use of dopamine drugs widely in veterinary practice especially in extensive stock breeding concerning the fact that presently there are no efficient drug or the therapy is conected with numerous contraindications.Furthermore, laboratory investigations on experimental animals will provide us with exact insigh even in the aethiology of some diseases which belongs to the formerly noted group of tissue damages i.e. Crohn disease and ulcerative colitis in humans, IBD in animals, gizzard erosions in chickens and mycotoxine lesions.

COOPERATION - PROJECTS


  1. Name of project: 3-01-031 Dopaminski agonisti u novim indikacijama
    Name of institution: Zavod za farmakologiju Medicinskog fakulteta U Zagrebu
    City: 10000 - Zagreb, Croatia

  2. Name of project: 3-01-032 Stresni odgovor želuca
    Name of institution: Medicinski fakultet, Zavod za farmakologiju
    City: 10000 - Zagreb, Croatia

COOPERATION - INSTITUTIONS


  1. Name of institution: Zavod za farmakologiju, Zavod za patologiju i patološku anatomiju Medicinskog fakulteta u Zagrebu, Zavod za kliničku patologiju "Prof. dr. Ljudevit Jurak" KLiničke bolnice "Sestre milosrdnice" Zagreb, PLIVA Istraživački institut-Biomedicina, Zagreb
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia
Other information about the project.
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