SVIBOR - Project code: 3-03-464

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
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Project code: 3-03-464


IMMUNOGLOBULINS A IN DIAGNOSTIC OF HUMAN AND VETERINARY MEDICINE


Main researcher: HRŽENJAK, TEREZIJA (16733)


Assistants
Type of research: applied
Duration from: 06/01/92. to 06/01/97.
Papers on project (total): 17
Papers on project quoted in Current Contents: 4
Institution name: Veterinarski fakultet, Zagreb (53)
Department/Institute: Department of biology
Address: Heinzelova 55, zagreb
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (01) 2390-142
Fax: 385 (01) 214-697
Summary: Immunoglobuline A is the main immunoglobulin in local tissues, specially mucose, and the most effective defence of them. Secretory IgA (SCIgA) has ability to connect with bacterial toxins, lipopolisaccharides of bacterial membrans or tumor antigens. So it inhibits to such way it binding of toxins and microorganisms to specific tissue (mucosal) receptors, inhibits activation of cyclic AMP and colonisation of microorganisms. The helth liver bind secretory component (SC) of immunoglobulin A, so IgA is in sera in inactive form. However, the sera values of IgA show the changes in local synthesis such as local immunological event. The changes of serum IgA concentrations insufficiently are evaluted in diagnostic and prognostic in humane and veterinary medicine. In our investigation sera IgA concentrations will be examined for human and different animals in depending of disease (infection, malignomas, parasithosis, dermathosis). We will try to find out the relationship of IgA and the other sera proteins (IgG, albumin, tumor markers, cellular immunity) in some disease. We wount to prove that the serum IgA concentration could be together with other paramethars a prognostic factor in diagnostics of some diseases.

Keywords: immunoglobulins, immunoglobulin A, anti-IgA antibodies, clinical assays, sera: humans and animals, infections, parasithosis, malignomas, dermathosis, prognosis, diagnosis

Research goals: Aimes: It is well know that healthy organisms produce constant concentrations of immunoglobulins. Changes of the circulation amount could be important prognostic factor. IgA is major immunoglobulin in defence when mucosal tissue is attacted. The high values of IgA in sera are sign of active defense of organisms, but loss of them is a sign of illiness progress. On want to study the values of IgA in sera of subjects suffering different illineses (infection diseases, malignomas, dermathosis, parasithosis). Changes of concentration of serum IgA will be put in relationship with concentration of other serum proteins. Results: This study the IgA concentration in sera of 276 patients suffering from primary malignat tumors located on different tissues and organs. Controls were 58 sera from healthy persons. The sera were screened by the referent method of Radial immunodiffusion (RID) and enzyme linked immunoapsorbent assay (ELISA). IgA is increased 30%-40% in sera of patients with carcinomas located on: head and neck, lung, brests, stomach and colon, malignant melanoma. Concentration of serum IgG was not increased. In sera of women with uterine cancer levels of IgG is much more increased then levels of IgA. Statistic valuation performed by computer program "Statgraphis". We consider, the high concentration of IgA is characteristic of earlier state of primary malignant tumors, and relationship IgA/IgG could show the immunological status of patients.

COOPERATION - PROJECTS


  1. Name of project: 3-03-312 IMUNOLOŠKA AKTIVNOST I PRIMJENA PRIPRAVKA DOBIVENOG IZ GUJAVICA (PORODICA LUMBRICIDAE)
    Name of institution: VETERINARSKI FAKULTET, SVEUČILIŠTE U ZAGREBU
    City: 10000 - Zagreb, Croatia

COOPERATION - INSTITUTIONS


  1. Name of institution: Bolnica za plućne bolesti - Jordanovac
    Type of institution: International organization
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Kinika za tumore i slične bolesti
    Type of institution: International organization
    City: 10000 - Zagreb, Croatia

  3. Name of institution: Pliva, farmacijsko, kemijska, prehrambena i kozmetičkaindustrija
    Type of institution: State institute
    City: 10000 - Zagreb, Croatia
Other information about the project.
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Last update: 10/11/95
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