SVIBOR - Project code: 3-03-472

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-03-472


Histopathological and histochemical studies of heart and coronary arteries in pigs


Main researcher: SABOČANEC, RUŽA (42065)


Assistants
Type of research: applied
Duration from: 04/01/92. to 04/01/95.
Papers on project (total): 5
Papers on project quoted in Current Contents: 1
Institution name: Veterinarski fakultet, Zagreb (53)
Communication
Summary: Studies on prevalence of systemic myopathies in pigs originated from a farm in 1992 were made up of taking the samples of m. gracilis, m. longissimus dorsi and m. semispinalis capitis from 50 healthy pigs at the abbatoir, before slaughtering. In all mentioned cases histopathological changes on blood vessels, predominantly fibrinoid degeneration with proliferation of macrophages in the walls and around numerous blood vessels were revealed. Bigger blood vessels had constricted lumen with fibroelastic thickening of the wall and infiltration of macrophages.In some blood vessels almost complete occlusion of lumen was found. In our investigation we decided that histopathological findings in the heart (myocard) and coronary arteries should be included in the study, and that is the working title of the project of one year duration. During 1993. we investigated changes in myocard of piglets after weaning, where, during manipulation sudden death of more than 60 piglets occured. Those piglets were from intensive production, from one farm. For the purposes of establishing the diagnose, gross examination of piglets was performed, and samples of organs (liver, spleen, small intestine) were taken for microbiological, and samples of heart musculature for histopathological examination. In those piglets histopathological examination revealed hyaline-waxy degeneration with focuses of myolysis, homogenisation, fragmentation i.e. discoidal destruction, with perimisium activation and intercelullar oedema, with infarction, but without distinguished changes in the walls of blood vessels, although there was visable extravasation. We emphasise that piglets were about 28 days old. At the end of 1993. we took samples of heart musculature of 50 fattening pigs originated from individual breeders, and those investigations are in progress.Our pathohistological study clearly shows that the cause of the sudden deaths were the heart failure due to diaetetic microanghiopathy with Vitamin E and selen deficiency, with coronary vessels lesions. Pathohistological analysis of the myocardium showed hyaline and waxy degeneration.

Keywords: heart, blood vessels, pig

Research goals: The goal of investigations is screening of mentioned pathology in intensive production of pigs with histopathological and histochemical examinations of blood vessels of heart, liver and lungs. Observations will establish the frequency of this pathology in pig's population, and will give us the view in the structure of losses due to insufficient circulation, whereas qualitative investigations will enable us to see the structure of histopathological changes and that would be the basis for better understanding the ethiology and pathogenesis of mentioned pathology. Our goal is to prevent losses in intensive production. Scientific contribution is in using contemporary histological and histochemical methods in the investigation, which will enable us to explain the ethiology and pathogenesis of the heart failure and insufficiency of circulation. Besides, pig has a comparative value as a model for the human pathology.

COOPERATION - PROJECTS


  1. Name of project: 3-03-308 Etiopatologija sustavnih miopatija životinja
    Name of institution: Veterinarski fakultet
    City: 10000 - Zagreb, Croatia

COOPERATION - INSTITUTIONS


  1. Name of institution: Svinjogojska farma PIP Sljeme, Sesvete
    Type of institution: State institute
    City: 10000 - Zagreb, Croatia

  2. Name of institution: PIK Kutjevo
    Type of institution: State institute
    City: 55340 - Kutjevo, Hrvatska
Other information about the project.
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