SVIBOR - Papers quoted in CC - project code: 3-04-319

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Papers quoted in Current Contents on project 3-04-319

Quoted papers: 12
Other papers: 72
Total: 84

Title: A QSAR study of 3-(phtalimidoalkyl)-pyrazolin-5-ones

Authors:: Nikolić, Sonja (84281); Medić-Šarić, Marica (74265); Matijević-Sosa, Julija (71850)

Journal: Croatica Chemica Acta
Number: 1
ISSN: 0011-1643
Volume: 66
Year: 1993
Pages: from 151 to 160
Number of references: 31
Language: engleski
Summary: A group of 17 new 3-(phtalaimidoalkyl)-pyrazolin-5-ones weretested for their mitodepressive activity upon the growth ofLepidium sativum L. seeds (Cresson). All of them have shown mitodepressive effect on the growth of the plant. Fourtopological indices (the Wiener index, the valence-connecitvityindex, the Balaban index and the information-theoretic index)were used in QSAR studies (inhibition of plant growth in % andcytostatic activity in ED50) on these compounds. We obtained QSARmodels that can predict cytostatic activity on the HeLa cells (inED50) with considerable accuracy.
Keywords: QSAR, topological indices, mitodepressive effect, prediction of, cytostatic activity

Title: A QSPR study of 3-(phtalimidoalkyl)-pyrazolin-5-ones

Authors:: Medić-Šarić, Marica (74265); Nikolić, Sonja (84281); Matijević-Sosa, Julija (71850)

Journal: Acta Pharmaceutica
Number: 2
ISSN: 0011-1643
Volume: 42
Year: 1992
Pages: from 153 to 167
Number of references: 52
Language: engleski
Summary: Several QSPR models with topological indices are proposed forpredicing physical properties of newly prepared3-(phthalimidoalkyl)-pyrazolin-5-ones. Four topological indiceswere used. These are the Wiener index, the valence connectivityindex, the Balaban index and the information-theoretic index. Thebest QSPR models were obtained using the Wiener index and thevalence connectivity index. The Balaban index and theinformation-theoretic index produced less accurate models. QSPRmodels based on combination of indices appear to be reliable.
Keywords: QSPR, models, topological indices, 3-(phthalimidoalkyl-pyrazolin-5-ones

Title: Testing urine for drugs

Authors:: Catlin, Don; Cowan, David; Donike, Manfred; Fraisse, Daniel; Oftebro, Helge; RENDIĆ, SLOBODAN

Journal: Annales de Biologie Clinique
Number: 5
ISSN: 0003-3898
Volume: 50
Year: 1992
Pages: from 359 to 366
Number of references: 36
Language: engleski
Summary: Publication is a Position Paper written for, and on request, ofInternational Federation of Clinical Chemistry by the group ofleaders of several internationally recognized analyticallaboratories. In the paper analytical procedures for drugtesting programes are presented. Special attention is focused ondrug misused in the society such as are narcotics, cocaine,marijuana and others as well as on several group of drugs andtheir metabolites misused in sport. Urine testing programes arediscussed in the scope of application in the clinicallaboratories with attention to: regulatory aspects, samplecollection procedure, chain of custody, analytical approach,quality assurance, interpretation, and documentation of theresults.
Keywords: urine, drug, misuse, society, sport, analytical procedures, legal approach, chain of custody, sample collection, quality assurance, interpretation, documentation of results

Title: Testing urine for drugs

Authors:: Catlin, Don; Cowan, David; Donike, Manfred; Fraisse, Daniel; Oftebro, Helge; RENDIĆ, SLOBODAN

Journal: Journal of Automatic Chemistry
Number: 3
ISSN: 0142-0453
Volume: 14
Year: 1992
Pages: from 85 to 92
Number of references: 36
Language: engleski
Summary: The paper represents the position paper prepared forInternational Federation of Clinical Chemistry discussing allrelevant factors and steps in the procedures for analysis of thedrugs and their metabolites in the urine sample. Specialattention has been paied to drugs misused in the society and insport. Various aspects of the analytical approach are discusedsuch as are: legal aspects, sample collection procedures, chainof custody, analytical approach and methods, quality assurance,interpretation and documentation of the results.
Keywords: urine, drugs, street drugs, sport drugs, metabolites, chain of custody, analytical procedures, legel approach, sample collection, quality assurance, interpretation, documantation, metabolism, pharmacokinetics

Title: Testing urine for drugs

Authors:: Catlin, Don; Cowan, David; Donike, Manfred; Fraisse, Daniel; Oftebro, Helge; RENDIĆ, SLOBODAN

Journal: Clinica Chimica Acta
Number: 3
ISSN: 0009-8981
Volume: 207
Year: 1992
Pages: from 13 to 26
Number of references: 36
Language: engleski
Summary: The publication represents a position paper prepared forInternational Federation of Clinical Chemistry discussing themost important aspects related to analysis of urine samples fordurgs and their metabolites with the special attention on drugsmisused in the society, and drugs misused in sport. Followingaspects and factors related to the drug analysis in urine samplesare discussed: legal approach, sample collection procedures chainof custody, analytical approach and procedures, qualityassurance, interpretation of the results, documentation ofresults.
Keywords: urine, drugs of abuse, in sport, in society, legal aspects, sample collection, chain of custody, analytical approach, quality assurance, interpretation of results, documantation of results

Title: Tixic effects and a structure property study of organic explosives, propellants, and related compounds

Authors:: Nikolić, Sonja (84281); Medić-Šarić, Marica (74265); RENDIĆ, SLOBODAN; Trinajstić, Nenad

Journal: Drug Metabolism Reviews
Number: 4
ISSN: 0360--253
Volume: 26
Year: 1994
Pages: from 717 to 738
Number of references: 52
Language: engleski
Summary: Physicochemical parameters such are molecular weight, density, diffusion coefficient, heat of fusion, and vapor pressure could be well correlated with selected molecular descriptors (the Wiener Index, The First-Order Connectivity Index, the Fifth-Order Connectivity Index, the Sixth-Order Valence-Connectivity Index, Balaban Index, and the Number of Non-hydrogen Atoms in the Molecule). Correlation studies were proposed for determination and prediction of the behavior of the explosives as pollutants in the environment as well as for their safety in production. Besides, the peper brings extensive discussion on the toxicological and biochemical properties of chemicals used as explosives and drugs, as well as mechanisms of toxicitz and biotransformation in the respect of the use of nonempirical parameters for prediction of the compounds behaviour in the environment.
Keywords: QSAR, QSPR, toxic effects, drugs, explosives

Title: Urinary excretion and metabolism of orally administered mefenorex

Authors:: RENDIĆ, SLOBODAN; Slavica, Meri; Medić-Šarić, Marica (74265)

Journal: European jouranl of drug metabolism and pharmacokinetics
Number: 2
ISSN: 0378-7966
Volume: 19
Year: 1994
Pages: from 107 to 117
Number of references: 21
Language: engleski
Summary: Metabolic pathways and the pharmacokinetic profile of mefenorex, and its main metabolite amphetamine have been studied in two healthy volunteers, after a single dose of mefenorex. Urinary concentrations were determined by gas chromatogarphy and metabolite structure was indentified by GC/MS following derivatization of urine extracts. A new urinarz metabolite of mefenorx was identified in the urine and the structure determined bz GC-MS. The kinetics of excretion of the metabolites and the unchanged drug (ratio amfetamine/mefenorex) was proposed as indication od the drug misuse in spor an the society.
Keywords: mefenorex, pharmacokinetics, metabolism, oral administration, urine metabolites, ratio amfetamine/mefenorex, structure of metabolites, GC-MS

Title: Binding of (+)- and (-)- Isomers and Racemate of Etomoxir to Human Serum Albumin and Effect of Stearic Acid and Stanozolol

Authors:: Vestemar, Vesna; Medić-Šarić, Marica (74265); RENDIĆ, SLOBODAN

Journal: Journal of Pharmaceutical Sciences
Number: 4
ISSN: 0022-3549
Volume: 83
Year: 1994
Pages: from 485 to 490
Number of references: 59
Language: engleski
Summary: Binding of (+)- and (-)- isomers and the racemate of etomoxir to the human serum albumin was studied by the gel filtration method. The experimental results are presented graphi using the method of Scatchard. Stereoselectivity of binding of the enantiomers was indicated together with difference in the binding mechanism, and the influence of edogenous (steric acid) and exogenous (stanozolol) comounds. The results were discused in respect to the different mechanisms and possible implication on the kinetics of the binding process.
Keywords: etomoxir, gel filtration, human serum albumin, Scatchard Plot, stereoselectivity, enantiomers, binding, stearic acid, stanozolol

Title: Application of numerical methods in the investigation of the flavonoids of Christ's thorn (Paliurus spina-christi Mill.)

Authors:: Maleš, Željan; Maleš, Željan; Medić-Šarić, Marica (74265); Kuštrak, Danica

Journal: Acta Pharmaceutica
Number: 2
ISSN: 1330-0075
Volume: 44
Year: 1994
Pages: from 183 to 191
Number of references: 35
Language: engleski
Summary: The efficiency of ten thin-layer silica gel chromatographic systems for separating flavonoids is compared by using the information theory and numerical taxonomy. The design of the most effective series of chromatographic systems is discussed in terms of individual DP of the systems and the inter-system correlation. The most favoruable cromatographical systems for the future quantitative analysis of the flavonoids Paliurus spina- christi Mill. are: ethylacetate:formic acid:acetic acid:water, 100:11:11:27, ethyl acetate: formic acid:water, 8:1:1 and chloroform:methanol:water, 6.5:3.5:1.
Keywords: Paliurus spina-christi Mill., flavonoids, information content, discriminating power, numerical taxonomy, dendrogram

Title: QSPR and QSAR study of phthalimidohydroxamic acids

Authors:: Nikolić, Sonja (84281); Medić-Šarić, Marica (74265); Matijević-Sosa, Julija (71850)

Journal: Acta Pharmaceutica
Number: 1
ISSN: 1330-0075
Volume: 45
Year: 1995
Pages: from 15 to 24
Number of references: 37
Language: engleski
Summary: Newly prepared phthalimidohydroxamic acids are tested for their mitodepressive effect on the growth of Lepidium sativum L. seeds (Cresson). Their partition coefficients, log P (o/w), are calculated by Rekker method. In the structure-property-activity study we have used topological indices to predict the physico-chemical properties and bioactivity of the prepared compounds. The optimal QSPR and QSAR models are obtained by using the valence connectivity index and the information-theoretic index.
Keywords: QSPR,QSAR, phthalimidohydroxamic acids, mitodepressive effect, Lepidium sativum L. (Cresson)

Title: URINARY EXCRETION AND METABOLISM OF ORALLY ADMINISTERED MEFENOREX

Authors:: RENDIĆ, SLOBODAN; Slavica, Meri

Number: NT A
ISSN: 3-89001-012-1
Volume: RECE
Year: 1994
Pages: from 197 to 230
Number of references: 114
Language: engleski
Summary: Pharmacokinetic and metabolis propserties of orallz administered mefenorex are presented. The strucutre of metabolite identified was determined by the GC-MS method.
Keywords: MEFENOREX, PHARMACOKINETICS, METABOLISM, ORAL ADMINISTRATION


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