- Type of paper
: Book
Title: Effects of war on the environment
- Editors
- RENDIĆ, SLOBODAN
Publisher: Croatian Society of Chemical Engineers
ISBN: 0022-9830
Year: 1994
Number of pages: 181
Language: engleski
Summary: ook brings lectures presented at the First International
Conference on the Effects of War On the Environment " which was held in
Zagreb, April 1993.Presedntations from the International Organiyationa, the
expert of UNIDO, Legal aspects, and case studies in Creoatia are presented.
Keywords: war, war activities, International organizations, environment, report, UNIDO expert, case studies, Legal aspects
Other:
- Type of paper
: Paper in book
Title: Metabolism of Testosterone
- Authors:
- RENDIĆ, SLOBODAN
- Editors
- Donike, Manfred
- Geyer, Hans
- Gotzmann, A.
- Mareck-Engelke, U.
- Rauth, Susane
Publisher: Verlag SPORT und BUCH Strauss-Edition Sport
ISBN: 3-89001-011-3
Year: 1993
Pages: from 27 to 46
Number of references: 32
Language: engleski
Summary: Metabolism of endogenous and exogenously
administeredtestosterone is presented, together with specific reactions
andenzymes which might influence interconversion of testosterone
toepitestosterone. The gorup of enzymes and specific isoenzymes
ofcytochrome P450 catalysing these reactions and reactions ofmetabolic
degradation are presented including influence ofdifferent drugs on their
activity.
Keywords: Testosteone, metabolism, hydroxylations, oxidoreductions, cytochrome P450, induction, inhibition, metabolites, excretion
- Type of paper
: Paper in book
Title: Identification of drug metabolites by gas
chromatography-mass spectrometry
- Authors:
- RENDIĆ, SLOBODAN
- Editors
- Shipe, James R.
- Savory, John
Publisher: International Union of Pure and Applied Chemistry
ISBN: 0-632-03181-6
Year: 1991
Pages: from 55 to 60
Number of references: 6
Language: engleski
Summary: In last several years a veriety of instrumental methods
usingmass spectrometry have been developed, to determine drugs andtheir
metabolites in biological sample. Application of theGC/MS/COMP system in
qualitative and quantitative determinationsof different classes of drugs
and metabolites has spreadprimarily to biochemistry, medicine and
toxicology in addition tocontrol the use of doping agents in sport. The
methods of samplepreparation and derivatization reagents used are suitable
forGC/MS analysis of parent drugs and metabolites with respect ofvolatility
thermal stability and fragmentation pattern. Asexamples determinations of
metabolites in urine samples afteradministration of mefenorex, etafedrine,
and drug Mucaine arepresented. In addition, influence of different
factors,particularly those inhibiting metabolism of doping agents
arediscussed.
Keywords: drug metabolites, doping agents, mass spectrometry, derivatization, analysis, inhibition of metabolism, urine samples, etafedrine, mefenorex, Mucaine, mephentermine
- Type of paper
: Paper in book
Title: Biological and Environmental Properties of Nitro-,
Nitramine- and Nitrate Compounds:Explosives and Drugs-Application of QSPR
and QSAR Studies in Environmental Toxicology Assessment
- Authors:
- Jurišić, Blaženka (142755)
- Medić-Šarić, Marica (74265)
- RENDIĆ, SLOBODAN
- Editors
- Richardson, Mervyn
Publisher: Taylor & Francis
ISBN: 0 7484 0305 1
Year: 1995
Pages: from 303 to 315
Number of references: 43
Language: engleski
Summary: Biological and environmental properties of chemicals which
are used as explosives and drugs is reviewed. In addition review and
discussion of the fate in the environemtn in respect to the fate in the
environment an in the biological system is presented.
Keywords: drugs, explosives, toxicity, environmental properties, metabolism, QSAR, QSPR, nitrates, nitramines, nitric esters
- Type of paper
: Paper in book
Title: Use and abuse of anabolic steroids in sport
- Authors:
- RENDIĆ, SLOBODAN
- Editors
- Pećina, Marko
- Heimer, Stjepan
Publisher: IK "Naprijed"
ISBN: 953-178-022-6
Year: 1995
Pages: from 303 to 307
Number of references: 11
Language: hrvatski
Summary: Use and misuse of anabolic steroids in sport is reviewed
together with the presentation of the methods and procedures used for
unambiguous determination and structural confirmation of endogenous as well
as exogenous steroid hormones. Examples are presented from the experience
of the doping control performed in the USA, and the discussion and
conclusions are based on the policy of the IOC Medical Commission and of
the International Federation of Clinical Chemistry. Side effects of
administration of anabolic steroids as well as analztical approach of their
determination on biological material is discussed.
Keywords: anabolics, steroids, side effects, metabolism, analytical determinations, international policy, toxicity, misuse
- Type of paper
: Paper in journal
Title: A comparative study of some topological indices and log P
in structure-property-activity analysis of phenylalkylamines
- Authors:
- Medić-Šarić, Marica (74265)
- Vestemar, Vesna
- Šarić, Slavko (46062)
- RENDIĆ, SLOBODAN
Journal: Acta Pharmaceutica
Number: 1
ISSN: 1330-0075
Volume: 43
Year: 1993
Pages: from 15 to 26
Number of references: 40
Language: engleski
Summary: Physico-chemical properties (lipophilicity-log P and
molecularmass-M.m.) and biological activity (norepinephrine
inhibition-logA) of phenylalkylamines were quantitatively analyzed.
Topologicalindices used for correlation analysis include Wiener's
number,Randić connectivity index, Balaban's index andinformation-theoretic
index. The comparasion of four topologicalindices shows that Wiener's
number is the most convenient as thestructural parameter in quantitative
structure-propertyrelationship (QSPR), as well as in
quantitativestructure-activity relationship (QSAR) analysis
ofphenylalkylamines. A number of indices, except Randićconnectivity index,
are found to be equieffective or superior tolog P in correlations with
biological activity.
Keywords: phenylalkylamines, QSPR, QSAR, logP, topological indices, structure-property-activity analysis
- Type of paper
: Paper in journal
Title: Application of information content and numerical taxonomy
in the development of HPLC methods
- Authors:
- Rotar, Aleš
- Kozjek, Franc
- Medić-Šarić, Marica (74265)
Journal: Acta Pharmaceutica
ISSN: 0011-1643
Volume: 43
Year: 1993
Pages: from 157 to 165
Number of references: 13
Language: engleski
Summary: Using a set of 15 quinolone derivatives analysed by means
of 9chromatographic systems, two different decision making tools inHPLC
were tested. Information content and numerical taxonomy wereapplied to
select the optimal set of rationally chosenchromatographic systems.
Selectivity was evaluated on the basisof retention data of individual
substances in all of the systems.Standardized k' data were shown to be more
relevant thanretention times or unprocessed k'. When used with suitable
inputdata, both methods proved to be powerful tools in selecting theoptimum
combination of HPLC systems to analyze a large number ofreal substances
having complex structures.
Keywords: information content, numerical taxonomy, quinolines, HPLC, chemometrics
- Type of paper
: Paper in journal
Title: QSPR and QSAR in pharmacy: Classical QSAR Models (Hansch
and Free-Wilsons Model)
- Authors:
- Jadrijević-Mladar Takač, Milena (136694)
- Medić-Šarić, Marica (74265)
Journal: Farmaceutski Glasnik
Number: 6
ISSN: 0014-8202
Volume: 47
Year: 1991
Pages: from 161 to 178
Number of references: 60
Language: hrvatski
Summary: QSAR models are characterized by basic assumptions with
respectto the relationship qetween the chemical structure and thebiological
activity of a compounds. Basic principles of the mostpoular QSAR model, the
linear free energy, extratherodinamic orHanschs model are discussed in
respect to its application in drugdesign.
Keywords: drug design, Hansch model, Free-Wilsonov model, structure-activity relatioship
- Type of paper
: Paper in journal
Title: Binding of hormons to plasma proteins with a rewiev to
testosterone
- Authors:
- Medić-Šarić, Marica (74265)
- Djeraković, Jasenka
- Vestemar, Vesna
- RENDIĆ, SLOBODAN
Journal: Farmaceutski Glasnik
Number: 12
ISSN: 014 -8202
Volume: 47
Year: 1991
Pages: from 343 to 360
Number of references: 18
Language: hrvatski
Summary: Metabolic and binding properties to plasma proteins of
steroidhormons taking testosterone as an example compound are
presented.Using gel filtration method the binding parameters oftestosterome
were determined. One set of equivalent binding sitesof low affinity
(K=17400 L/mol) for binding of testosterone toHSA was found. The percent of
binding was from 12% to 30 %depending on the concentration of the ligand.
Binding curvesindicate nonsaturable process.
Keywords: steroid hormons, testosterone, binding to human serum protein, gel filtration
- Type of paper
: Paper in journal
Title: Significance of binding of drugs to plasma proteins for
the biological activity and drug fate in organism
- Authors:
- Medić-Šarić, Marica (74265)
- Vestemar, Vesna
- Posarić, Jasna
- Djeraković, Jasenka
- RENDIĆ, SLOBODAN
Journal: Farmaceutski Glasnik
Number: 11
ISSN: 014 -8202
Volume: 47
Year: 1991
Pages: from 303 to 315
Number of references: 24
Language: hrvatski
Summary: Factors influencing drug-protein interactions are discussed
inrespect of specific biological response of the drug (therapeuticand/or
toxic). Special atention is focused to thestereoselectivity of binding of
drugs belonging to1,4-benzodiazepines.
Keywords: binding, drugs, plasma proteins, factors influencing, stereoselectivity
- Type of paper
: Paper in journal
Title: The influence of lipophylicity on biochemical processes
and drug action
- Authors:
- Medić-Šarić, Marica (74265)
- Vestemar, Vesna
- RENDIĆ, SLOBODAN
Journal: Farmaceutski Glasnik
Number: 1
ISSN: 014 -8202
Volume: 47
Year: 1991
Pages: from 1 to 16
Number of references: 24
Language: hrvatski
Summary: The influence of lipophylicity on the accumulation of drugs
in anorganism, on the metabolism of drugs, and on the other processesof
importance for drug actions such as are elimination, passthrugh the
cerebrospinal liquor, binding on the plasma proteinsare disscussed. Special
attention was paied to the parameter ofthe lipophylicity, partition
coefficient (logP). The relation ofthis parameter with the structural
parameteres, moleculardescriptors in QSAR and QSPR is presented as well.
Keywords: Lipophylicity, drugs, action, metabolism, structure-activity relationship, QSPR, QSAR
- Type of paper
: Paper in journal
Title: Biochemistry of drug metabolism studies: metabolism of
testosterone and T/E ratio
- Authors:
- RENDIĆ, SLOBODAN
Journal: Acta Pharmaceutica
Number: 3
ISSN: 1330-0075
Volume: 44
Year: 1994
Pages: from 215 to 227
Number of references: 56
Language: engleski
Summary: Metabolism of testosterone and formation of the end
products of its metabolism by catalytic activity of cytochrome P-450
enzymes is presented. Selected reactions of testosterone metabolism and
influence of other drugs, including steroids are discussed in relation to
the formation and excretion of metabolites. Results of clinical studz are
presented (the clinical studz was performed at the University of
California, Los Angeles, Department of Pharmacology, Dr. Don Catlin). On
the basis of the GC-MS analysis the structure of metabolite was determined
in the urine (11beta-hydroxytestosterone) as a new urinary metabolite and
the ratios of hydroxylated metabolites was proposed as a paramtere
indicating administration of egsogenous testosterone.
Keywords: testosterone, hydroxylations, cytochrome P-450, T/E ratio, the ratio of, hydroxylated metabolites, 11beta-hydroxytestosterone, drug-drug-interactions, urinary excretion
- Type of paper
: Paper in journal
Title: Metabolism of drugs in doping control: human cytochrome
P-450 (CYP) enzymes, interactions, adverse effects
- Authors:
- RENDIĆ, SLOBODAN
Journal: Hrvatski športskomedicinski vjesnik
Number: 1
ISSN: 0354-0766
Volume: 10
Year: 1995
Pages: from 8 to 28
Number of references: 63
Language: engleski
Summary: Catalytic properties of human cytochrome P450 (CYP) enzymes
are reviewed regarding their involvement in metabolism of both the
clinically used drugs and the drugs that are banned or restricted in sport.
Of about 36 families of CYP enzymes identified until now, only few of them
(familiesCYP 1, 2 i 3) are involved in metabolism of drugs in humans.
Similarly to other drugs, also metabolism of doping agents by CYP enzymes
is influenced by a number of factors including genetic polymorphism.
Clinically important drugs are presented in tables regarding their
participation as substrates, inductors or inhibitors of cytochrome P450
enzymes in humans. These data are proposed for use as information for
prediction of drug-drug interactions and toxic effects of drugs and certain
chemicals.
Keywords: doping control, humane cytochrome P450 (CYP) enzymes
- Type of paper
: Paper in journal
Title: Human cytochrome P450 (CYP) enzymes, interactions, adverse
effects
- Authors:
- RENDIĆ, SLOBODAN
Journal: Hrvatski športskomedicinski vjesnik
Number: 1
ISSN: 0354-0766
Volume: 10
Year: 1995
Pages: from 8 to 28
Number of references: 63
Language: engleski
Summary: Catalytic properties of human cytochrome P450 enzymes are
reviewed regarding thier involvement in metabolism and side effects of
clinically important drugs, and drugs that are misused in sport and the
society.
Keywords: cytochrome P450, metabolism, drugs, side effects, toxicity, misuse, sport
- Type of paper
: Paper in journal
Title: The role and nature of metabolic reactions catalyzed by
enzymes cytochrome P450 (CYP) in biological effects of medicines
- Authors:
- RENDIĆ, SLOBODAN
Journal: Medicus
Number: 1
ISSN: 1330-013X
Volume: 4
Year: 1995
Pages: from 49 to 66
Number of references: 41
Language: hrvatski
Summary: The paper represents and overview of biochemical and
catalytic properties of enzymes that are involved in metabolism of drugs.
Particular attention has been focused to clinically significant drug-drug
interactions and toxic effects that results from coadministration of drugs
metabolised by the same enzyme. Tabular listing of drugs that are
substrates, inhibitors or inductors of the enzymes in human is presented.
Keywords: metabolizm, drugs, enzymes, interactions, inductions, inhibitions, side effects, toxicity, cytochromes P450,
- Type of paper
: Paper in proceedings
Title: BIOCHEMICAL AND HISTOCHEMICAL EFFECTS OF NAPHTHENE TYPE
PETROLEUM OIL FRACTIONS:POTENTIAL USE IN COSMETOLOGY
- Authors:
- RENDIĆ, SLOBODAN
- PULJKO, DAHNA
- GOMERČIĆ, VERA
- JAMNICKY,
- MARKOVIĆ, ZDRAVKO
- RENDIĆ, SLOBODAN
Proceedings title: THE COSMETIC IMAGE: A MOSAIC OF BIOSCIENCES
Language: engleski
Place: VENEZIA, ITALY
Year: 1994
Pages: from 479 to 498
Meeting: 18th International I.F.S.C.C. Congress
Held: from 10/03/94 to 10/06/94
Summary: BIOCHEMICAL AND HISTOPATHOLOGICAL EFFECTS WERE STUDIED IN
MALE FISCHER 344 RATS AFTER REPEATED SUBCUTANEOUS AND PERCUTANEOUS
ADMINISTRATION OF NAPHTHALENE TYPE OIL FRACTIONS, BEFORE AND AFTER
DEAROMATIZATION. DOSES ADMINISTERED WERE 0.25 ML/RAT/DAY AND 1.0 ML/RAT/DAY
FOR A PERIOD OF 21 DAYS. BIOCHEMICAL PARAMETERS IN SERUM AND TRIGLYCERIDE
SERUM LEVELS WERE CHANGED. SIGNIFICANT TREATMENT-RELATED INCREASE IN THE
RELATIVE LIVER WEIGHTS, CYTOCHROME P-450 AND B5 CONTENT WAS OBSERVED. MEAN
BODY WEIGHT OF ANIMALS TREATED WITH RF SAMPLE SHOWED MARKED DECREASE. GC-MS
ANALYSIS CONFIRMED THE PRESENCE OF AROMATIC COMPOUNDS.
Keywords: OIL FRACTIONS, NAPHTHENE TYPE, SUBCUTANEOUS, PERCUTANEOUS, BIOCHEMICAL AND HISTOCHEMICAL EFFECTS, CYTOCHROME P-450. INDUCTION, TOXICITY, BIOCHEMICAL ACTIVATION, CZTOCHROME B5, GC-MS
- Type of paper
: Paper in proceedings
Title: BINDING OF ANABOLIC STEROIDS TO HUMAN SERUM ALBUMIN AND
POSSIBLE INTERACTIONS WITH OTHER DRUGS
- Authors:
- Jurišić, Blaženka (142755)
- Medić-Šarić, Marica (74265)
- RENDIĆ, SLOBODAN
- Vestemar, Vesna
- Editors
- Donike, Manfred
- Geyer, Hans
- Gotzmann, A.
- Mareck-Engelke, U.
Proceedings title: Recent Aadvances in Doping Aanalysis (2)
Language: engleski
Place: KOLN, GERMANY
Year: 1995
ISBN/ISSN: 3-89001-013-X
Pages: from 15 to 18
Meeting: 12TH COLOGNE WORKSHOP ON DOPE ANALYSIS
Held: from 04/10/94 to 04/15/94
Summary: Binding of testosterone, epitestosterone and metandienone
to human serum albumin was investigated. The binding parameters were
calculated by the method of Scatchard. Displacement and the mechanisms of
binding was investigated in the presence of other anabolic steroids
(stanozolol). In addition to binding parameters, mechanisms of binding and
the displacement are discussed and proposed.
Keywords: plasmma proteins, steroids, anabolics, binding, displacement, binding parameters, testosterone, metandienone, stanozolol, epitestosteron, mechanisms
- Type of paper
: Paper in proceedings
Title: URINARY EXCRETION AND METABOLISM OF ORALLY ADMINISTERED
MEFENOREX
- Authors:
- RENDIĆ, SLOBODAN
- Slavica, Meri
- Editors
- Donike, Manfred
- Geyer, Hans
- Gotzmann, A.
- Mareck-Engelke, U.
Proceedings title: RECENT ADVANCES IN DOPING ANALYSIS
Language: engleski
Place: KOLN, GERMANY
Year: 1994
ISBN/ISSN: 3-89001-012-1
Pages: from 197 to 230
Meeting: 11TH COLOGNE WORKSHOP ON DOPE ANALYSIS
Held: from 03/07/93 to 03/12/93
Summary: Pharmacokinetic and metabolis propserties of orallz
administered mefenorex are presented. The strucutre of metabolite
identified was determined by the GC-MS method.
Keywords: MEFENOREX, PHARMACOKINETICS, METABOLISM, ORAL ADMINISTRATION
- Type of paper
: Paper in proceedings
Title: The role of metabolism studies in the evaluation of
biological activity of cosmetic products
- Authors:
- RENDIĆ, SLOBODAN
- Editors
- Hrvatsko društvo kozmetičkih a,
Proceedings title: Biomedicinski aspekti kozmetike
Language: hrvatski
Place: Zagreb
Year: 1994
Pages: from 151 to 163
Meeting: Prvi skup Hrvatskog društva kozmetičkih kemičara, Medicinski apsekti kozmetike
Held: from 10/13/93 to 10/15/93
Summary: Skin, similarly to other organs and tissues, metabolizes
drugs and other wenobiotics generating metabolites and intermediates of
diverse biological activity. In difference to other organs and tissues, as
the most external organ, skin is continuosly and directly exposed to
variety of environmental chemicals, as well as to drugs, and cosmetic
chemicals.
Keywords: skin, metabolism, cytochrom P450
- Type of paper
: Paper in proceedings
Title: In vitro metode kod ispitivanja biološke aktivnosti
kemijskih tvai koje se koriste u kozmetologiji
- Authors:
- RENDIĆ, SLOBODAN
Proceedings title: Od kontrole kvalitete do cjelovitoga upravljanja kvalitetom
Language: hrvatski
Place: Stubičke Toplice, Hrvatska
Year: 1995
Meeting: Stručni dani HDKK '95.
Held: from 05/16/95 to 05/18/95
- Type of paper
: Paper in proceedings
Title: Metabolism of testosterone
- Authors:
- RENDIĆ, SLOBODAN
- Editors
- Donike, Manfred
- Geyer, Hans
- Gotzmann, A.
- Mareck-Engelke, U.
- Rauth, Susane
Proceedings title: Proceedings of the 10th Cologne workshop on dope analysis
Language: engleski
Place: KOLN, GERMANY
Year: 1993
ISBN/ISSN: 3-89001-011-3
Pages: from 27 to 46
Meeting: 10th Cologne workshop on dope analysis
Held: from 06/07/92 to 06/12/92
Summary:
Matabolism of testosterone and factors that might influence T/E ratio is
discused.
Keywords: tesosterone, epitestosterone, endogenous steroids, metabolism, T/E ratio, enzymes
- Type of paper
: Summary in proceedings
Title: Environmental risks from warfare
- Authors:
- Simončič, Viktor
- RENDIĆ, SLOBODAN
- Editors
- Holahan, Nancy
Proceedings title: ISSX Proceedings, Fourth European ISSX Meeting Bologna, Italy
Language: engleski
Place: Bethesda, USA
Year: 1992
ISBN/ISSN: ISSN1061-3439
Pages: from 39 to 39
Meeting: Fourth European ISSX Meeting
Held: from 06/03/92 to 06/06/92
Summary: Several aspects of environmetal devastation as a
consequence ofaggresion against Croatia have been discussed and
illustrated(industrial plants, cultural heritage, munitions and
warchemicals). The environmental devastation was compared to thesame during
the war in Gulf.
Keywords: warfare, Croatia, environemtal devastation, industrial plants, cultural heritage, war- and military chemicals, Gulf-war
- Type of paper
: Summary in proceedings
Title: Urinary excretion and metabolism of orally administered
mefenorex
- Authors:
- Slavica, Meri
- Medić-Šarić, Marica (74265)
- RENDIĆ, SLOBODAN
- Editors
- Garattini, Silvio
Proceedings title: Thirteenth European Worshop on Drug Metabolism
Language: engleski
Place: Bergamo, Italija
Year: 1992
Pages: from 1 to 1
Meeting: Thirteenth European Workshop on Drug Metabolism
Held: from 09/21/92 to 09/25/92
Summary: Metabolic pathways and pharmacokinetic parameters were
determinedfrom urine analysis data following oral administration of
thedrug. Urinary concentrations of the drug and metabolites weredetrmined
by the GC and the structure of novel metabolites wasdetermined by GC/MS.
Keywords: mefenorex, metabolic pathways, farmacokinetics, urine analysis, GC, GC/MS, novel metabolites
- Type of paper
: Summary in proceedings
Title: The role of metabolic studies in the evaluation of
biological activity of cosmetic products
- Authors:
- RENDIĆ, SLOBODAN
Proceedings title: Biomedicinski aspekti kozmetike, Zbirka sažetaka
Language: hrvatski
Place: Zagreb
Year: 1993
Pages: from 1 to 1
Meeting: Prvi skup Hrvatskog društva kozmetičkih kemičara, Medicinski apsekti kozmetike
Held: from 10/13/93 to 10/15/93
Summary: In the paper metabolic reactions of skin tissue, in
comparisonwith the similar from other organs and tissues is
presented.Particular attention is focused to the possible
reactiveintermediates and metabolites which might be formed in the courseof
biotransformation reactions catalyzed by cytochromes P450. Theformation of
toxic metabolites is discussed in the view ofinhibition and induction of
the cytochrome P450 enzymes byenvorinmetal but also cosmetic chemicals and
drugs.
Keywords: metabolic reactions, skin tissue, active intermediates, metabolites, cytochrome P450, activation, induction, inhibition, toxicity
- Type of paper
: Summary in proceedings
Title: Biochemical investigation in drug metabolism
Proceedings title: Godišnji sastanak hrvatskih biokemičara
Language: engleski
Place: Zagreb
Year: 1993
Pages: from 64 to 64
Meeting: Godišnji sastanak hrvatskih biokemičara, Jubilarni simpozij u čast prof. dr. Pavla Mildnera
Held: from 06/17/93 to 06/18/93
Summary: Review on the application of biochemical studies in
investigationof mechanisms of biological actions of drugs.
Keywords: new drugs, metgods of testing, evaluation, biochemical methods
- Type of paper
: Summary in proceedings
Title: Binding of etomoxir on human serum albumin
- Authors:
- Vestemar, Vesna
- Medić-Šarić, Marica (74265)
- RENDIĆ, SLOBODAN
Proceedings title: XIII. Skup hrvatskih kemičara, Sinopsisi
Language: engleski
Place: Zagreb
Year: 1993
Pages: from 301 to 301
Meeting: XIII. Skup hrvatskih kemičara
Held: from 02/10/93 to 02/11/93
Summary: Enantioselectivity of binding of isomers of etomoxir
isinvestigated and kinetically characterized.
Keywords: enentioselectivity, binding to plasma proteins, human serum albumin, etomoxir, enentiomers, competition, stsnozolol, stearic acid
- Type of paper
: Summary in proceedings
Title: Effect of temperature on reaction of N-alpha-acetyl
microperoxidase-8 with peracetic acid
- Authors:
- Jurišić, Blaženka (142755)
- Van Wart, H.E.
- RENDIĆ, SLOBODAN
Proceedings title: XIII. Skup hrvatskih kemičara
Language: engleski
Place: Zagreb
Year: 1993
Pages: from 300 to 300
Meeting: XIII. Skup hrvatskih kemičara
Held: from 02/10/93 to 02/11/93
Summary: Reaction of N-alpha-acetyl microperoxidase-8 has been
invetigatedat different temperature conditions, kinetically
characterisedand proposed mechanism of the reaction.
Keywords: microperoxidase-8, mechanism of reaction, temperature dependance, reaction kinetics
- Type of paper
: Summary in proceedings
Title: Evaluation and selection of optimal solvents and solvent
combinations in thin-layer chromatography of steroid hormons and
metabolites
- Authors:
- Medić-Šarić, Marica (74265)
- Šarić, Slavko (46062)
Proceedings title: New achievements in chromatography, Abstracts
Language: engleski
Place: Opatija
Year: 1992
Pages: from 11 to 11
Meeting: New achievements in chromatography
Held: from 10/13/92 to 10/15/92
Summary: Application of the method of numerical taxonomy for
rapidselection and optimization of solvents and solvent systems
forchromatographic analysis of endogenous steroids and theirmetabolites.
The method is applied for 21 monohydroxy metabolitesof testosterone,
androstenedione and progesterone.
Keywords: numerical taxonomy, chromathography, solvents, solvent systems, testosterone, androstenedione, progesterone, monohydroxy metabolites
- Type of paper
: Summary in proceedings
Title: Metabolism and QSPR studies of amphetamine and related
compounds
- Authors:
- Medić-Šarić, Marica (74265)
- Vestemar, Vesna
- Slavica, Meri
- RENDIĆ, SLOBODAN
Proceedings title: XII. Sastanak kemičara Hrvatske
Language: hrvatski
Place: Zagreb
Year: 1991
Pages: from 78 to 78
Meeting: XII. Sastanak kemičara Hrvatske
Held: from 02/11/91 to 02/13/91
Summary: Metabolic studies in vivo are reported for
mefenorex,farmacokinetic parameters are determined for the drug and
itsmetabolite amphetamine. QSPR studies are performed for
mefenorex,amphetamine and related compounds.
Keywords: mefenorex, amphetamine, related compounds, metabolism, pharmacokinetics, QSPR
- Type of paper
: Summary in proceedings
Title: Effects of stanozolol on pharmacokinetics of urinary
excreted caffeine
- Authors:
- Jurišić, Blaženka (142755)
- Bezjak, Aleksandar
- Grahovac, Irena
- RENDIĆ, SLOBODAN
Proceedings title: XII. Sastanak kemičara Hrvatske
Language: hrvatski
Place: Zagreb
Year: 1991
Pages: from 226 to 226
Meeting: XII. Sastanak kemičara Hrvatske
Held: from 02/11/91 to 02/13/91
Summary: Pharmacokinetic parameters of caffeine in the presence
ofanabolic steorid stanozolol are determined. Caffeineconcentration in
urine samples were determined by the HPLCmethod.
Keywords: caffeine, pharmacokinetics, stanozolol, influence of, urine samples
- Type of paper
: Summary in proceedings
Title: Investigation of reltionships between physical-chemical
and perfume properties of bornyl-acetate and similar terpenes
- Authors:
- Medić-Šarić, Marica (74265)
- Blažević, Nikola (4041)
- Medić-Šarić, Marica (74265)
Proceedings title: XII. Sasatank kemičara Hrvatske
Language: hrvatski
Place: Zagreb
Year: 1991
Pages: from 76 to 76
Held: from 02/11/91 to 02/13/91
Summary: Investigation of structural-topological properties of
bicyclicterpenes similar to bornyl-acetate.
Keywords: bornyl-acetate, topological indices, parfume properties
- Type of paper
: Summary in proceedings
Title: Application of molecular modeling techniques in
invstigation of new synthesizing phtahlimido-pyrazoles
- Authors:
- Medić-Šarić, Marica (74265)
- Matijević-Sosa, Julija (71850)
- Talaja, Jasna
Proceedings title: XII. Sastanak kemičara Hrvatske
Language: hrvatski
Place: Zagreb
Year: 1991
Pages: from 77 to 77
Meeting: XII. Sastanak kemičara Hrvatske
Held: from 02/11/91 to 02/13/91
Summary: New phthalimido-pyrazoles are synthesized and
structure-propertyanalysis were performed.
Keywords: phthalimido-pyrazoles, topological indices, structural properties
- Type of paper
: Summary in proceedings
Title: Determination of aluminium traces in hemodialysis fluids
by means of thin-layer chromatography
- Authors:
- Jezidžić, Bruna
- Medić-Šarić, Marica (74265)
- Turina, Srećko (71745)
Proceedings title: VI. YUSAC 1991
Language: hrvatski
Place: Sarajevo, Bosna i Hercegovina
Year: 1991
Pages: from 1 to 1
Meeting: 6. YUSAK, Sarajevo
Held: from 10/09/91 to 10/11/91
Summary: Procedure for determination of aluminium by
coprecipitationmethod with iron III hydroxide, together with identification
andquantitative detremination by TLC method is described.
Keywords: aluminium, determination, quantitative determination, identification, coprecipitation method, TLC
- Type of paper
: Summary in proceedings
Title: A QSAR study of 3-(phthalimidoalkyl)-pyrazolin-5-ones
- Authors:
- Medić-Šarić, Marica (74265)
- Nikolić, Sonja (84281)
- Matijević-Sosa, Julija (71850)
Proceedings title: Math/Chem/Comp 1992
Language: engleski
Place: Zagreb
Year: 1992
Pages: from 1 to 1
Meeting: The sevnth international course and conference on the interface between mathematics, chemistry and computer science
Held: from 02/22/92 to 06/26/92
Summary: A QSAR study of 3-(phthalimidoalkyl)-pyrazolin-5-ones.
Keywords: QSAR, 3-(phthalimidoalkyl)-pyrazolin-5-ones, mitodepressive effect, cytistatic effect, HeLa cells
- Type of paper
: Summary in proceedings
Title: Determination of aluminium by quantitative thin-layer
chromatography in water solution with preceeding coprecipitation
- Authors:
- Medić-Šarić, Marica (74265)
- Jezidžić, Bruna
- Turina, Srećko (71745)
Proceedings title: New achievements in chromatography
Language: engleski
Place: Opatija
Year: 1992
Pages: from 11 to 11
Meeting: New achievements in chromatography
Held: from 10/13/92 to 10/15/92
Summary: Determination of aluminium by the spectrophtometrical
method.
Keywords: aluminium, determination, spectrophotometric method
- Type of paper
: Summary in proceedings
Title: QSPR and QSAR study of new synthesized derivatives of
pyrroles and pyrrolinones
- Authors:
- Medić-Šarić, Marica (74265)
- Nikolić, Sonja (84281)
- Gaon, Igor Davor
- Lovren, Fina
- Škrbo, Armin
- Rimpapa, Zlatan
Proceedings title: XIII. Sastanak kemičara Hrvatske, Sinopsisi
Language: hrvatski
Place: Zagreb
Year: 1993
Pages: from 74 to 74
Meeting: XIII. Skup hrvatskih kemičara
Held: from 02/08/93 to 02/10/93
Summary: New derivatives of pyrroles and pyrrolinones were
synthesized,and antimicrobial activity determined. QSPR and QSAR studies
wereperformed.
Keywords: pyrroles, pyrrolinones, antimicrobial activity, QSPR, QSAR
- Type of paper
: Summary in proceedings
Title: QSAR study of some isatin N-Mannich bases
- Authors:
- Medić-Šarić, Marica (74265)
- Nikolić, Sonja (84281)
- Ivaniš, Sanja
Proceedings title: Math/Chem/Comp '93
Language: hrvatski
Place: Rovinj, Hrvatska
Year: 1993
Pages: from 1 to 1
Meeting: 6. YUSAK, Sarajevo
Held: from 06/21/93 to 06/25/93
Summary: Investigation of mitodepressive activity of new isatin
N-Mannichbases and QSAR studes are performed.
Keywords: isatin N-Mannich bases, mitodepressive activity, QSAR
- Type of paper
: Summary in proceedings
Title: QSAR study of phthalimido-hydroxamic acids
- Authors:
- Nikolić, Sonja (84281)
- Medić-Šarić, Marica (74265)
- Matijević-Sosa, Julija (71850)
- Ivaniš, Sanja
Proceedings title: Math/Chem/Comp '93
Language: engleski
Place: Rovinj, Hrvatska
Year: 1993
Pages: from 2 to 2
Meeting: The eighth international course and conference on interface among mathematics, chemistry and computer sciences
Held: from 06/21/93 to 06/25/93
Summary: New synthesized phthalimidohydroxamic acids
ellicitedmitodepressive effects. QSAR studies were performed.
Keywords: phthalimido hydroxamic acids, mitodepressive effects, QSAR
- Type of paper
: Summary in proceedings
Title: In vitro methods for Evaluation of Biological Activity of
Chemicals Used in Cosmetology
- Authors:
- RENDIĆ, SLOBODAN
Proceedings title: Od kontrole kvalitete do cjelovitog upravljanja kvalitetom
Language: hrvatski
Place: Koprivnica, Hrvatska
Year: 1995
Meeting: stručni dani HDKK'95
Held: from 05/16/95 to 05/18/95
Summary: According to international regulations the "cosmetic
products put on the market must not cause damage to human health when they
are applied under normal or reasonable foreseeable conditions of
use".Therefore, the minimum information on cosmetic ingredients (coloring
agents, preservatives, UV filters etc.) are necessary. That includes data
on acute toxicity, dermal absorption and irritation, sub-chronic toxicity,
mutagenicity, phototoxicity etc.
Keywords: in vitro, in vivo, cosmetology
- Type of paper
: Summary in proceedings
Title: Human cytochrome P450 (CYP) enzymes in doping control:
Metabolism, interactions, adverse effects
- Authors:
- RENDIĆ, SLOBODAN
- Editors
- RENDIĆ, SLOBODAN
- Donike, Manfred
Proceedings title: Proceedings of the 13th Cologne Workshop on Doping Analysis
Language: engleski
Place: KOLN, GERMANY
Year: 1995
Pages: from 1 to 1
Meeting: 13th Cologne workshop on Dope Analysis
Held: from 03/12/95 to 03/17/95
Summary: Review on the influence of the metabolic reactions
catalyzed by cytochrome P450 enzymes on the results of the analysis in
doping control laboratories is presented. Also possible toxic effects of
drugs missused in sport is discussed in the wiev of the metabolic reactions
catalysed by the CYP enzymes .
Keywords: dopig control, cytochromes P450, metabolic reactions, misuse, analysis, interpretation, adverse effects, drugs
- Type of paper
: Summary in proceedings
Title: Applications of molecular modelling and lipophilicity in
study of chemicals used as drugs and explosives
- Authors:
- PULJKO, DAHNA
- Medić-Šarić, Marica (74265)
- RENDIĆ, SLOBODAN
- Editors
- Graovac, Ante
Proceedings title: The tenth international course & conference on the interfaces betweem mathematic
Language: engleski
Place: Dubrovnik
Year: 1995
Meeting: MATH/CHEM/COMP '95
Held: from 06/26/95 to 07/01/95
Summary: Lipophilicity is a prime physico-chemical descriptor of
xenobiotics with relevance to their biological properties. The hydrophobic
interaction of drugs with receptors, the pharmacokinetics behaviour and
toxicological properties are examples for a steadily increasing number of
topics in which lipophilicity plays an important role.
Keywords: lipophilicity, indices, QSAR
- Type of paper
: Summary in proceedings
Title: Metabolic studies in doping control: Testosterone
metabolism and testosterone/epitestosterone ratio in human urine as an
indicator of the steroid misuse
- Authors:
- RENDIĆ, SLOBODAN
Proceedings title: 6th North American ISSX Meeting ISSX Proceedings
Language: engleski
Place: Raleigh, USA
Year: 1994
ISBN/ISSN: 1061-3439
Pages: from 250 to 250
Meeting: 6th North American ISSX Meeting
Held: from 10/23/94 to 10/27/94
Summary: Testosterone, epitestosterone metabolism in respect to
misuse of endogenous steroids in sport is presented. Based on the clinical
studz a new ratio of testosterone metabolites is presented as a criterium
for tastosterone misuse in sport.
Keywords: testosterone, epitestosterone, metabolism, T/E ratio, GC/MS, urine, human, sport, misuse
- Type of paper
: Summary in proceedings
Title: A structure-toxicity study of organic explosives and
related compounds
- Authors:
- Nikolić, Sonja (84281)
- Lučić, Bono
- Milošević, Sanja
- Medić-Šarić, Marica (74265)
- RENDIĆ, SLOBODAN
Proceedings title: XIV. SKUP HRVATSKIH KEMIČARA
Language: engleski
Place: Zagreb
Year: 1995
Pages: from 252 to 252
Meeting: XIV. Skup hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
Summary: A sructure-toxicity study of nitro compounds, which serve
as organic explosives and propellants, is caried out by topological
indices. Toxicity data are taken from Rosenblatt et al. We considered
bioconcentration factor in fish and beef, and acute toxicities to rodents.
Stucture-toxicity models with several kinds of indices are tested. The
simplest and best models are obtained by using connectivity indices. In the
present theoretical framework these are the models with highest
predictivity for considered biological properties.
Keywords: nitrate, nitramine, nitro-compounds, toxicity, QSAR, QSPR,
- Type of paper
: Summary in proceedings
Title: GC-MS analysis of partially purified naphthene type
petroleum oil fractions use in skin disease treatmen
- Authors:
- RENDIĆ, SLOBODAN
- SLOVENC, MLADEN
- TODORIĆ, ANTE
- PULJKO, DAHNA
Proceedings title: XIV. SKUP HRVATSKIH KEMIČARA
Language: engleski
Place: Zagreb
Year: 1995
Pages: from 299 to 299
Meeting: XIV. Skup hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
Summary: GC-MS analysis confirmed the presence of acyclic
sesquiterpenes, bicyclic sesquiterpenoids, acyclic diterpenoids, tryciclic
terpenoids, pregnane (C21) and sterane (27) related compounds in both
preparations.
Keywords: naphthene, GC-MS analysis
- Type of paper
: Summary in proceedings
Title: Topological aspects in investigations of steroid hormones
- Authors:
- Medić-Šarić, Marica (74265)
- RENDIĆ, SLOBODAN
- Arafat, Muhamed
Proceedings title: XIV. SKUP HRVATSKIH KEMIČARA
Language: engleski
Place: Zagreb
Year: 1995
Pages: from 254 to 254
Meeting: XIV. Skup hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
Summary: The two groups of steroid hormones were investigated:
a) Androgens with anabolic effect
b) Anabolics with low androgenic effect.
QSPR study of these compounds have been investigated.
Keywords: steroids, QSPR
- Type of paper
: Summary in proceedings
Title: Study of the structural requirements of heme moiety for
ligand binding of cimetidine
- Authors:
- Jurišić, Blaženka (142755)
- RENDIĆ, SLOBODAN
- Dragun, Zrinka
Proceedings title: XIV. SKUP HRVATSKIH KEMIČARA
Language: engleski
Place: Zagreb
Year: 1995
Pages: from 212 to 212
Meeting: XIV. Skup hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
Summary: In the present work we investigate structural requirements
of cimetidine as ambidentate ligand for binding to CYP enzymes,
horseradish, Ac-MP-8 as well as with a model porphyrins Co(II)PPIX and
Co(II)TPP. The results showed interaction of cimetidine with Co-model
porphyrins and with CYP enzymes, and no interaction with either HRP or
Ac-MP-8.
Keywords: cimetidine, ciano group, ligand, hem models, hem enzymes, peroxidases. binding
- Type of paper
: Summary in proceedings
Title: The structure-property-activity study of compounds used as
drugs and explosives
- Authors:
- RENDIĆ, SLOBODAN
- Nikolić, Sonja (84281)
- Medić-Šarić, Marica (74265)
- Trinajstić, Nenad
Proceedings title: 14 th EUROPEAN WORKSHOP ON DRUG METABOLISM
Language: engleski
Place: Paris, France
Year: 1994
Pages: from 182 to 182
Meeting: 14th EUROPEAN WORKSHOP ON DRUG METABOLISM
Held: from 07/03/94 to 07/08/94
Summary: The stucture-property-activity relationship study is
performed with topological indices for prediction of possible toxic effects
of selected nitroaromatic, nitramine, and nitrate compounds used as drugs
and explosives. The later compounds are potential environmental pollutants
following both wartime and military activities in peace.
Keywords: Explosives, propellants, nitramine, nitroaromatic compounds.
- Type of paper
: Summary in proceedings
Title: Study of the structural requirements of heme moiety for
ligand binding of cimetidine
- Authors:
- RENDIĆ, SLOBODAN
- Jurišić, Blaženka (142755)
- Dragun, Zrinka
Proceedings title: 4TH INTERNATIONAL ISSX MEETING
Language: engleski
Place: Seattle, USA
Year: 1995
ISBN/ISSN: 1061-3439
Pages: from 258 to 258
Meeting: 4th International ISSX Meeting
Held: from 08/27/95 to 08/31/95
Summary: Ligan properties of cimetidine have been investigated in
binding with the model hem compounds and hem enzymes.
Keywords: cimetidine, ligand properties, hem models, hem enzymes, binding, mechanisms
- Type of paper
: Summary in proceedings
Title: Metabolism of anabolic steroids in man: testosterone
metabolism and testosterone/epitestosterone ratio as an indicator of the
steroid misuse in sport
- Authors:
- RENDIĆ, SLOBODAN
Proceedings title: Mednarodni simpozij in XXIV. Krkine nagrade 1994
Language: engleski
Place: Novo Mesto, Slovenia
Year: 1994
Pages: from 23 to 23
Meeting: Mednarodni simpozij in XXIV. Krkine nagrade 1994.
Held: from 12/07/94 to 12/08/94
Summary: A review on testosterone-other drugs interaciotn and the
methods for testosterone/epitestosterone determination in urine has been
desribed.
Keywords: testosterone, epitestosterone, ratoi, drug interactions, metabolism, methods, determination, urine
- Type of paper
: Summary in proceedings
Title: A Structure-Toxicity Study of Organic Explosives and
Related Compounds
- Authors:
- Milošević, Sanja
- Medić-Šarić, Marica (74265)
- RENDIĆ, SLOBODAN
- Nikolić, Sonja (84281)
- Editors
- Graovac, Ante
Proceedings title: MATH/CHEM/COMP '94
Language: engleski
Place: Zagreb
Year: 1994
Meeting: The ninth Dubrovnik International Course and Conference on the Interfaces Among Mathematics, Chemistry and Computer Science
Held: from 06/26/94 to 07/01/94
Summary: A structure toxicity model, based on the topological
indices, is derived for organic explosives such as nitro aromatic and other
nitrated compounds. The folowing topological indices have been used: the
Wiener index, W, the Connectivity indices, X, the Balaban index, J and
information-theoretic indices. The model based on the connectivity indices
possess acceptable statistical characteristics.
Keywords: Wiener index, Connectivity indices, Balaban index, the information-theoretic indices
- Type of paper
: Summary in proceedings
Title: A comparative study of lipophilicity and biological
activity of 3-(phthalimidoalkyl)-pyrazolin-5-ones
- Authors:
- Nikolić, Sonja (84281)
- Medić-Šarić, Marica (74265)
- Matijević-Sosa, Julija (71850)
- Editors
- Testa, Bernard
Proceedings title: log P,An International Symposium on Lipophilicity in Drug Research and toxicolog
Language: engleski
Place: Lausanne, Switzerland
Year: 1995
Pages: from P-61 to P-61
Meeting: log P, An International Symposium on Lipophilicity in Drug Research and Toxicology
Held: from 03/21/95 to 03/24/95
Summary: The compounds analyzed in this report are 17 new
derivatives of 3-(phthalimidoalkyl)-pyrazolin-5-ones recently synthesized
in our group. All studied compounds were tested for their mitodepressive
activity upon the growth of Lepidium sativum L. seeds. The inhibiton of the
seeds growth was significant for derivatives of glycine and of alanine,
which are used in QSAR study of supstituted pyrazoles with known cytostatic
activity (ED 50) on the HeLa cells. Topological indices found to be
equieffective or superior to log P in correlations with biological
activity.
Keywords: 3-(phthalimidoalkyl)-pyrazolin-5-ones, Lepidium sativum L., QSAR, ED50, HeLa cells, topological indices, log P
- Type of paper
: Summary in proceedings
Title: Relationships between the properties and topological
indices of the new synthesized phthalimidoisoxasolones
- Authors:
- Medić-Šarić, Marica (74265)
- Matijević-Sosa, Julija (71850)
- Nikolić, Sonja (84281)
Proceedings title: XIV SKUP HRVATSKIH KEMIČARA
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 253 to 253
Meeting: XIV. Skup hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
Summary: In this comunications,we reported on the synthesis of some
new phthalimidoisoxasolones.Structure-property models with several kinds of
indices are tested.The best models are obtained by using connectivity index
and the Balaban index, modified for heterosystems.
Keywords: QSPR, phthalimidoisoxasolones, molecular modeling, topological indices.
- Type of paper
: Summary in proceedings
Title: Numerical methods in the investigation of the flavonoids
of Paliurus spina-christi Mill.
- Authors:
- Medić-Šarić, Marica (74265)
- Maleš, Željan
- Brantner, Adelheid
Proceedings title: XIV.SKUP HRVATSKIH KEMIČARA
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 305 to 305
Meeting: XIV. Skup hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
Summary: Experiments were carried out with six new flavonoids in ten
TLC-systems.The measure of selectivity is the information content, and the
discriminating power is the measure of probability.Classification of
chromatographic systems into groups with similar separation properties and
selection of the most efficient TLC-systems from each group are carried out
by the methods of numerical taxonomy.
Keywords: Paliurus spina-christi Mill., numerical taxonomy, flavonoids.
- Type of paper
: Summary in proceedings
Title: A topological indices and log P in structure-property
analysis of steroid hormones
- Authors:
- Medić-Šarić, Marica (74265)
- RENDIĆ, SLOBODAN
Proceedings title: FIP.95 STOCKHOLM
Language: engleski
Place: STOCKHOLM, ŠVEDSKA
Year: 1995
Pages: from 119 to 119
Meeting: FIP.95
Held: from 08/28/95 to 09/01/95
Summary: The lipophilic character of steroids has an important role
in regulating the biological activity of these compounds.Lipophilicity and
physico-chemical properties of steroid hormones were quantitatively
analyzed.In this purpose, partition coefficient, log P,has been calculated
according to the Rekker method and for correlation analysis the topological
indices were used.The best models have been obtained by using Wiener number
and Balaban index modified for heteroatoms.
Keywords: Lipophilicity, log P, Rekker method,topological indices,Wiener index, Balaban index.
- Type of paper
: Summary in proceedings
Title: Investigation of flavonoids from Lamium species by
thin-layer chromatography
- Authors:
- Medić-Šarić, Marica (74265)
- Vladimir-Knežević, Sanda
- Maleš, Željan
Proceedings title: XIV SKUP HRVATSKIH KEMIČARA
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 306 to 306
Meeting: XIV. Skup hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
Summary: Using a set of 9 flavonoid compounds and 4 phenolic
acidsanalysedby means of 10 chromatographic systems two different decision
making tools in TLC were tested.Information content and numerical taxonomy
were applied to select the optimal set of rationally chosen chromatographic
systems.The flavonoids and fenolic acids have been isolated from Lamium
species.
Keywords: Flavonoids, fenolic acids, information content, numerical taxonomy, Lamium sorties.
- Type of paper
: Summary in proceedings
Title: Investigation of the flavonoids of Zizyphus jujuba Mill.
by the numerical methods
- Authors:
- Medić-Šarić, Marica (74265)
- Maleš, Željan
- Prstojević, Jasna
- Puzović, Marko
Proceedings title: FIP.95
Language: engleski
Place: STOCKHOLM, ŠVEDSKA
Year: 1995
Pages: from 178 to 178
Meeting: FIP.95
Held: from 08/28/95 to 09/01/95
Summary: Zizyphus jujuba Mill. is a small tree, which grows in
China,Australia, America, Asia and Mediterranean.This plant is mostly used
in folk medicine to heal bronchitis, diarrhea and ulcers.Chemical
investigation of this plant indicated the presence of flavonoids and
phenolic acids. Experiments were carried out by TLC methods in thirteen
systems and selection of the most efficient TLC-systems were carried out by
the methods of numerical taxonomy.
Keywords: Zizyphus jujuba Mill., flavonoids, phenolic acids, TLC-method, numerical taxonomy.
- Type of paper
: Ph.D.
Title: Structural characterization of the isolated flavonoids of
Christ s thorn- Paliurus spina christi Mill.
Faculty: Farmaceutsko-biokemijski fakultet ZAGREB
Author: MALEŠ ŽELJAN
Date of defense: 02/10/95
Language: hrvatski
Number of pages: 159
Summary: Seven flavonoids have been isolated from the leaves of
Paliurus spina-christi Mill. by the chromatographic methods. Their
structures have been established by the spectroscopic methods (UV,NMR). The
isolated flavonoids were characterized as derivatives of quercetin,
kaempferol and scoparin.Derivatives of quercetin have exhibited an
antimicrobial effect.The efficiency of ten TLC-systems for separating
flavonoids was compared by using the information theory and numerical
taxonomy.
Keywords: Paliurus spina-christi Mill., flavonoids-structural characterization, antimicrobial effect, numerical taxonomy.
- Type of paper
: M.A.
Title: Binding of isomers of sodium
2/6-(4-chlorophenoxy)-hexyl/-oxiran-2-carboxylat-dihydrat to the human
serum albumin
Faculty: Farmaceutsko-biokemijski fakultet ZAGREB
Date of defense: 10/27/93
Language: hrvatski
Number of pages: 85
Summary: Binding of (+)-, (-)-isomer and racemate of etomoxir to the
humanserum albumin (HSA) was studied using gel filtration method.
Theexperimental results showed statistically significant differencein
affinity of binding of (+)-isomer when compared tothat for (-)-isomer and
racemate (p<0,05).The binding wasinfluenced by the presence of competitive
ligands stearic acidand stanozolol.The binding kinetics of the (+)-isomer
wasdifferent compared to (-)-isomer and racemate also in thepresence of the
competitive ligand anabolic hormone stanozolol.It was concluded that
stanozolol affects binding of the(+)-isomer predominately at its high
affinity sites.
Keywords: Protein binding, human serum albumin, etomoxir, enentiomers, racemate, stereoselectivity of binding, competitive ligands, stearic acid, stanozolol
- Type of paper
: Mentorship
Title: Binding of isomers of sodium
2/6-(4-chlorophenoxy)-hexyl/-oxiran-2-carboxylat-dihydrat to the human
serum albumin
Faculty: Farmaceutsko-biokemijski fakultet ZAGREB
Mentor: RENDIĆ SLOBODAN
Date of defense: 10/27/93
Number of pages: 85
Author: Vestemar dipl. inž. farm. Vesna
Degree level: M.A.
- Type of paper
: Invited lecture
Title: Drugs and Chemicals as Inhibitors of Cytochrome P450
Enzymes: Therapeutic and Toxicological Consequences
Institution: Karl-Franzens-Univerzitat Graz
Year: 1994
- Type of paper
: Invited lecture
Title: Metabolism of Anabolic Steroids in Man: Testosterone
netabolism and Testosterone/Epitestosterone Ratio as an Indicator of the
Steroid Misuse in Sport
Institution: International Szmposium and XXIVth KRKAs Prizes
Year: 1994
- Type of paper
: Invited lecture
Title: The role of metabolism studies in the evaluation of
biological activity of cosnetic products
Institution: Prvi nacionalni tečaj sportske medicine, Hrvatski Olimpijski Odbor
Year: 1993
- Type of paper
: Invited lecture
Title: Urinary excretion and metabolism of orally administered
mefenorex
Institution: Deutsche Sporthoch Schule, Koln
Year: 1993
- Type of paper
: Invited lecture
Title: Binding of anabolic steroids to human serum albumin and
possible interactions with other drugs
Institution: Deutsche Sporthoch Schule, Koln
Year: 1994
- Type of paper
: Invited lecture
Title: Metabolism of Testosterone
Institution: Deutsche Sporthoch Schule, Koln
Year: 1992
- Type of paper
: Invited lecture
Title: Testosterone, Metabolismus und Missbrauch
Institution: Fakultat fur Biologie, Universitat Konstanz
Year: 1992
- Type of paper
: Invited lecture
Title: Nitroaromatic, Nitrate esters, and Nitramine Compounds -
Explosives and Drugs: Toxicity, QSPR, QSAR
Institution: Fakultat fur Biologie, Universitat Konstanz
Year: 1994
- Type of paper
: Invited lecture
Title: Drug metabolism and human cytochromes P450 (CYP) enzymes
in doping control: Variability, Interactions, adverse effects
Institution: Deutsche Sporthoch Schule, Koln
Year: 1995
- Type of paper
: Invited lecture
Title: Biochemical investigations in preclinical testong of drugs
Institution: Istraživački institut-Pliva
Year: 1994
- Type of paper
: Invited lecture
Title: Use and misuse of anabolic steroids in sport
Institution: Prvi nacionalni tečaj sportske medicine, Hrvatski Olimpijski Odbor
Year: 1994
- Type of paper
: Invited lecture
Title: Application of in vitro models for testing of chemicals in
cosmetology
Institution: Sastanak Društva kozmetičkih kemičara Hrvatske
Year: 1995
- Type of paper
: Invited lecture
Title: Human CYP enzymes, biological properties of drugs and
toxicity of chemicals
Institution: Istraživački institut-Pliva
Year: 1995
- Type of paper
: Invited lecture
Title: Biological activity of chemicals - food and drugs
Institution: Podravka
Year: 1994
- Type of paper
: Invited lecture
Title: Chemical additives in food: advantage and disandvantage
Institution: Podravka
Year: 1994
