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Papers quoted in Current Contents on project 3-04-321


Quoted papers: 36
Other papers: 50
Total: 86


Title: Macromolecular prodrugs. III. Esters of Fenoprofen and Probenecid

Authors:
Butula, Ivan (6372)
Zorc, Branka
Journal: Acta Pharm.
Number: 1
ISSN: 1330-0075
Volume: 44
Year: 1994
Pages: from 103 to 108
Number of references: 13
Language: engleski
Summary: Fenkoprofen and probenecid were covalently linked by ester bonds to ŕ,á-poly(N-hydroxyethul)-DL-aspartamide (PHEA), hydrophilic polymer, previously proposed as a drug carrier and plasma expander. In addition, two simple esters of fenoprofen and probenecid were prepared. Ester bondings were achieved via benzotriazolides synthesized by the reaction of 1-benzotriazole carboxylic acid chloride with fenoprofen and probenecid, respectively. Release of the drug from PHEA-drug esters in alkaline medium was studied.
Keywords: prodrug, macromolecular carrier, ŕ,á-poly(N-hydroxyethyl)-DL-aspartamide, fenoprofen ester, probenecid ester, 1-benzotriazole carboxylic acid chloride

Title: Macromolecular prodrugs V. Polymer-broxuridine conjugates

Authors:
Zorc, Branka
Maysinger, Dušica
Kalčić, Igor
Butula, Ivan (6372)
Journal: Int.J.Pharmac.
ISSN: 0378-5173
Volume: 123
Year: 1995
Pages: from 65 to 70
Number of references: 15
Language: engleski
Summary: Broxuridine was covalently bound to PHEA and PAHA. Broxuridine was first chemically modified and bound to PHEA by carbonate and phosphodiester linkages, and to PAHA by an amide type bond. Neuroepithelia cells were used as a model system to assess the suitability of the conjugated broxuridine for cell proliferation. Parallel experiments were perormed with unconjugated broxuridine and the extent of incorporation into DNA was determined by immunocytochemistry using an broxuridine antibody.
Keywords: polymeric prodrug, polymer-drug conjugate, broxuridine, cell proliferation, immunocytochemistry

Title: Controlled release formulations of potassium chloride produced by fluidized bed film coating and spray-drying technique

Authors:
Bećirević, Mira (2761)
Begić, Veronika
Journal: Pharmazie
Number: H5
ISSN: 0031-7144
Volume: 49
Year: 1994
Pages: from 339 to 342
Number of references: 10
Language: engleski
Summary: Fluidized bed film coating and a spray-drying technique provided by Eudragit RS were used for prolonging potassium chloride release. The effect of the polymers on the dissolution data of the prepared formulations was investigated. In an attempt to obtain more information on the release kinetics, dissolution data kof coated drug crystals, their tablets and spray-dried products were examined from the viewpoint of first-order kinetics, the Higuchi square root law and the modified Hixson-Crowell model. The drug release was characterized by a rapid release phase followed by a slow release phase. The dissolution data showed that the release of potassium chloride from the formulations proceeded in sustained patterns at a moderate rate.
Keywords: potassium chloride, controlled release, fluidized bed film coating, spray-drying technique

Title: Inclusion complexation of indomethacin with cyclodextrins in solid state

Authors:
Bećirević, Mira (2761)
Journal: S.T.P. Pharma Sciences
Number: 4
ISSN: 1157-1489
Volume: 4
Year: 1994
Pages: from 282 to 286
Number of references: 14
Language: engleski
Summary: Complex formation of lindomethacin with ŕ-, á- and g-cyclodextrins and dimethyl á-cyclodextrin (DIMEB) were studied by the solubility and UV-spectrophotometric methods. By comparing the apparent stability constants evaluated by the two methods, it was possible to characterize the stability of the inclusion complexes and to establish, in part, their stoichiometries. The solid complexes of indomethacin with cyclodextrins in molar rations of 1/1 were prepared by employing the freeye-drying technique. The influence of cyclodextrins on diffusion throuh a semi-permeable membrane were evaluataed according to the first-order kinetics of diffusion from the solutions containing indomethacin alone or in the complex form. The apparent dialytic rate constants of the complexes were lower than that of the free indomethacin.
Keywords: Indomethacin inclusion complexes, cyclodextrins, stability constants, apparent dialztic rate constants

Title: The properties of some ambiphilic vehicles

Authors:
Čajkovac, Mira (7606)
Milojica, Draga
Journal: Acta Pharm.
Number: 2
ISSN: 1330-0075
Volume: 45
Year: 1995
Pages: from 131 to 138
Number of references: 9
Language: engleski
Summary: The properties of self-prepared ambiphilic vehicles and of a similar commercial product have been investigated. It was established that thez are either O/W systems or belong to a mixed type. According to their appearance and rheological properties they can be defined as creams or emulsoids. Self-prepared vehicles can bind a maximum of 64.5 to 105.5% (m/m) of liquid paraffin whereas a commercial sample is only able to bind 51% (m/m). The addition of a maximal amount of oil creates preparation of W/O type which are very sensitive to mechanical stress. Therefore, their rheological properties cannot be determined. Samples with 45% (m/m) of liquid paraffin or almond oil are emulsoids too, but not all of them belong to the W/O tzpe. A comparison with "basic" vehicles showts that they are characterized by lower viscosities and values for theoretical yield shear. On the contrary, the hydrophilicity of all samples was much higher because they accept 565 to 756% (m/m) of water (the commeracial sample 810%). The addition of 300% (m/m) and more of water changes the structure of the initial "basic" vehicles, so that mobile O/W type emulsions develop from the lamellar gel structure which is characteristic for ambiphilic systems. These (highly) diluted emulsions possess pseudoplastic properties and low values for apparent viscosity and theoretical yield shear.
Keywords: ambiphilic vehicles, ambiphilicity, structural properties, apparent viscosity

Title: QSPR and QSAR study of phthalimidohydroxamic acids

Authors:
Nikolić, Sonja
Medić-Šarić, Marica (74265)
Matijević-Sosa, Julija (71850)
Journal: Acta Pharm.
Number: 1
ISSN: 1330-0075
Volume: 45
Year: 1995
Pages: from 15 to 24
Number of references: 9
Language: engleski
Summary: Newly prepared phthalimidkohydroxamic acids are tested for their mitodepressive effect on the growth of Lepidium sativum L. seeds (Cresson). Their partition coefficients, log P (o/w), are calculated by Rekker method. In the structure-property-activity study we have used topological indices to predict the physico-chemical properties and bioactivity of the prepared compounds. The optimal QSPR and QSAR models are obtained by using the valence connectivity index and the information-theoretic index.
Keywords: QSPR, QSAR, phthalimidohydroxamic acids

Title: 1-(3-Benzoylphenyl)ethanone (I) and 3-Benzoyl-ŕ-methylbenzeneacetamide Methylene Chloride Solvate (2/1) (II)

Authors:
Matak, Dijana
Vinković, Mladen
Dumić, Miljenko (133202)
Journal: Acta Crystallogr. Sect. C
Volume: 50
Year: 1994
Pages: from 1339 to 1342
Number of references: 8
Language: engleski
Summary: 1-(3-Benzoylpherojektuspace group P21/c, with a 10.681 (1), b 10.509 (1), c 11.157 (1) A, and á 107.38 (2); Z = 4, dc = 1.22; R = 0.070, Rw = 0.099 for 1227 reflections. 3-Benzoyl-ŕ-methylbenzeneacetamide methylene chloride solvate (2/1) (II), is monoclinic, space group C2/c, with a 23.902 (10), b 8.064 (2), c 15.669 (3) A, and á 93.11 (2); Z = 8, dc = 1.30; R = 0.0826, Rw = 0.1210 for 1947 reflections. At. coordinates are given. While the acetyl group in I is nearly coplanar with the Ph ring (O2-C14-C1-C2 6.8 (5) and positioned opposite the C7 = O1 group, the 2-propanamido group in II is almost perpendicular to the corresponding Ph ring (C16-C14-C1-C2 134.0 (4), C15-C14-C1-C2 - 102.4 (5) and occupies the same side as the C7=O1 group.
Keywords: 1-(3-Benzoylphenyl)ethanone, 3-Benzoyl-ŕ-methylbenzeneacetamide methylene chloride solvate (2/1), X-ray diffraction

Title: Preparation, characterization and release of microencapsulated bromodeoxyuridine

Authors:
Maysinger, Dušica
Filipović-Grčić, Jelena (136683)
Alebić-Kolbah, Tanja
Journal: Life Sciences
ISSN: 0024-3205
Volume: 54
Year: 1994
Pages: from 27 to 34
Number of references: 16
Language: engleski
Summary: Biodegradable and biocompatible microspheres with bromodeoxyuridine (BrUrd) have been prepared, characterized and tested in vitro and in vivo. Scaning electron microscopy and image analysis revealed regular spherical shapes and an average size of 2.47 Šm. Total content of BrUrd as determined by HPLC was within the range of 0.2 - 1.5 %. Preliminary data from immunocytochemical studies revealed efficient incorporation of BrUrd delivered from these microcapsules into nuclei of proliferating cells surrounding brain lesions in rats.
Keywords: microspheres, bromodeoxyuridine, immunocytochemistry, proliferating cells

Title: Alginate microspheres of microbial spores and viable cells of Bacillus subtilis

Authors:
Pepeljnjak, Stjepan
Filipović-Grčić, Jelena (136683)
Jalšenjak, Vesna (52171)
Journal: Pharmazie
Number: H.6
ISSN: 0031-7144
Volume: 49
Year: 1994
Pages: from 436 to 437
Number of references: 6
Language: engleski
Summary: Microspheres of Bacillus subtilis (microbial spores and viable cells) were prepared by using sodium alginate. Some typical properties of microencapsulated systems such as content of microorganisms, particle size and germination time were studied. Very mild conditions during the preparation step enables one to produce microspheres containing cells with no apparent changes in their general biological properties, but gives them protection with a soft hydrogel matrix in the same time does not prevent completely the communication with the surrounding medium.
Keywords: microspheres, Bacillus subtilis, sodium alginate, hydrogel matrix

Title: Microparticles with neuroactive agents

Authors:
Filipović-Grčić, Jelena (136683)
Maysinger, Dušica
Jalšenjak, Ivan
Journal: J. Microencapsulation
Number: 4
ISSN: 0265-2048
Volume: 12
Year: 1995
Pages: from 343 to 362
Number of references: 65
Language: engleski
Summary: An overview of biodegradable and biocompatible microcapsules and microspheres loaded with neuroactive substances, or cells producing neuroactive substances, and their role as drug delivery systems (DDS) for drug administration to the central nervous system (CNS) is given. In addition, closely related systems are also summarized.
Keywords: microcapsule, microsphere, biodegradable, biocompatible, neuroactive

Title: Macromolecular prodrugs. IV. Alginate-chitosan microspheres of PHEA-L-dopa adduct

Authors:
Filipović-Grčić, Jelena (136683)
Maysinger, Dušica
Zorc, Branka
Jalšenjak, Ivan
Journal: Int.J.Pharmac.
ISSN: 0378-5173
Volume: 116
Year: 1995
Pages: from 39 to 44
Number of references: 11
Language: engleski
Summary: A polymeric prodrug ŕ,á-poly(N-hydroxyethyl-DL- aspartamide-L-dopa adduct (PHEA-L-dopa) was microencapsulated in alginate-chitosan microspheres in order to achieve drug release from a complex reservoir device. The gel/matrix material of alginate-chitosan complex protects the adduct from hydrolysis by the surrounding medium. On the basic of a 10000-fold difference between the drug released from microspheres as the adduct and that released in the unbound form, a model of the microencapsulated system was proposed.
Keywords: PHEA-L-dopa adduct, alginate, chitosan, microsphere, prodrug

Title: Encapsulated genetically engineered fibrobasts: release of nerve growth factor and effects in vivo on recovery of cholinergic markers after devascularizing cortical lesions

Authors:
Maysinger, Dušica
Piccardo, P.
Liberini, Paolo
Jalšenjak, Ivan
Cuello, Claudio
Journal: Neurochem.Int.
Number: 5
ISSN: 0197-0186
Volume: 24
Year: 1994
Pages: from 495 to 503
Number of references: 38
Language: engleski
Summary: Genetically engineered rat fibroblasts producing nerve growth factor (NGF) were encapsuled in alginate-polylysine-alginate gels with the objective to produce viable "minifactories" continuously producing and secreting NGF into the rat brain. Microencapsulated fibroblasts (NGF) secretors and NGF non-secretors) were placed onto the surface of the lesioned rat cortex (unilateral devascularizing lesion) and animals were sacrificed 30 days after surgery. Fibroblasts NGF-non sescreters normally produce tumors after implantation, therefore, they were irradiated prior to encapsulation. Three other experimental groups were studied in parallel: non-lesioned (controls), lesioned rats receiving "empty" alginate spheres and lesioned animals without treatment and microspheres. Biochemical analysis of microdissected brain tissues of lesioned animals treated with encapsulated NGF-secretor fibroblasts showed a significant increase in choline acetyltransferase (ChAT) activity in cortices adjacent to the lesion but not far from it (entorhinal cortex). Morphometric analysis of ChAT-IR and low affinity NGF-receptor IR cholinergic neurons in the middle ortion of the NBM shows a prevention of neuronal shrinkage and extensive neuropil in animals treated with microencapsulated NGF-secretor fibroblasts. The results of this study demonstrate that NGF from encapsulated genetically engineered fibroblasts can be secreted for at least long enough to prevent degenerative changes of cholinergic neurons in the NBM.
Keywords: microcapsule, nerve growth factor, alginate-polylysine gels, genetically engineered cells, fibroblasts

Title: A Non-Ionic Surfactant Vesicle-in-Water-in-Oil (v/w/o) System: Potential Uses in Drug and Vaccine Delivery

Authors:
Yoshioka, Toshimitsu
Škalko, Nataša (34134)
Gursel, Mayda
Gregoriadis, Gregory
Florence, Alexander T.
Journal: J. of Drug Targeting
Volume: 2
Year: 1995
Pages: from 533 to 539
Number of references: 16
Language: engleski
Summary: An aqueous dispersion of niosomes (non-ionic surfactant vesicles) emulsified in an external oil phase forms the vesicle-in-water-in-oil (v/w/o) system described in this paper. The properties of the surfactant used to form the vesicles, the surfactant or surfactant mixture used to stabilize the emulsion and the nature of the oil phase can be changed to provide systems of different capacities for drug or antigen and different release characteristics. The same nonionic surfactant is used as the principle amphipile to form the niosomes and to stabilize the w/o emulsion, thus promoting stability by decreasing transfer of surfactant between the stabilizing monolayers and the vesicle bilayers. The in vitro release of carboxyfluoroscein and 5-fluorouracil encapsulated within the niosomes of the v/w/o system has been investigated, the nature of the oil phase and surfactant-oil interactions being important in determining the rate of solute release. Initial studies of the system in vivo, as an adjuvant for tetanus toxoid, using cottonseed oil as the external oil phase, showed enhanced immunological ativity over the free antigen or vesicles.

Title: Antibodies against phosphatidylinositol and inositol monophosphate specifically inhibit tumour necrosis factor induction by malaria exoantigens

Authors:
Bate, Clive
Taverne, Janice
Bootsma, Harry
Mason, Richard
Škalko, Nataša (34134)
Gregoriadis, Gregory
Playfair, John
Journal: Immunology
Volume: 76
Year: 1992
Pages: from 35 to 41
Language: engleski
Summary: The active component of the exoantigens of malarial parasites which stimulates macrophages to secrete tumour necrosis factor (TNF) has been shown to depend upon a phospholipid, the activity of which was blocked by phosphadidylinositol (PI) and inositol monophosphatae (IMP) in competitive inhibition studies. Antisera made against the exoantigens of Plasmodium yoelli, which inhibited their induction of TNF, were found by an ELISA assay to contai antibody against several other phospholipids. When incorporated into liposomes several other phospholipids did give rise to inhibitory antibodies but, in contrast to the antisera against parasite exoantigens, PI and IMP, the inhibitory activity was removed by adsorption with heterologous phospholipid liposomes, suggesting that it was directed against a common determinant, presumably the phosphate ester head group. Inhibitory antibodies in the antisera tested wer predominantly IgM and titres were not increased after repeated injections. Antisera raised against Pi, IMP or the crossreacting phospholipid liposomes also inhibited TNF secretion by macrophages stimulated by exoantigens of the human parasites P. falciparum and P. vivax, but not by bacterial lipopolysaccharide. These findings confirm our conclusion that exoantigens from these different species contain phosphate bound to inositol in their TNF-inducing moiety.
Keywords: antibody, liposomes, malaria exoantigens


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