- Type of paper
: Paper in book
Title: In vitro release from microcapsules and microspheres
- Authors:
- Jalšenjak, Ivan
- Editors
- Donbrow, Max
Publisher: CRC Press
ISBN: 0-8493-6986-x
Year: 1992
Pages: from 193 to 218
Number of references: 138
Language: engleski
Summary: The intention of this Chapter is to present some basic
principlesof drug release from microcapsules and to give an overview
ofensemble release properties of microencapsulated drugs.
Keywords: microcapsules, microspheres, in vitro release, kinetics
- Type of paper
: Paper in book
Title: Release of L-dopa from HSA microspheres into the rat
brain: in vitro and in vivo characterization by microdialysis
- Authors:
- Maysinger, Dušica
- Jalšenjak, Vesna (52171)
- Stolnik, Snježana (137052)
- Jalšenjak, Ivan
- Editors
- Whateley, Tony L.
Publisher: Harwood Academic Publ.
ISBN: 3-7186-5247-1
Year: 1992
Pages: from 269 to 275
Number of references: 13
Language: engleski
Summary: HSA-microspheres containing L-dopa were steroataxically
injecteddirectly into the brain region, and the drug release was followedby
microdialysis technique. The results provide evidence thatL-dopa
incorporated in the HSA microspheres can be a feasibletherapeutic modality
for the localized delivery of the drug intostriatal tissue.
Keywords: L-dopa, HSA microspheres, microdialysis, Parkinsons disease
- Type of paper
: Paper in journal
Title: Reaction of pyruvic acid with nitrosobenzenes
- Authors:
- Uršić, Stanko (51201)
- Vrček, Valerije
- Gabričević, Mario
- Zorc, Branka
Journal: J.Chem.Soc.Chem.Commun.
Number: 4
ISSN: 0022-4936
Year: 1992
Pages: from 296 to 298
Number of references: 13
Language: engleski
Summary: Pyruvic acid reacts with nitrosobenzenes in both
acid-catalysedand uncatalysed reactions giving N-phenylacetohydroxamic
acids.
Keywords: pyruvic acid, nitrosobenzene, hydroxamic acid, catalysis
- Type of paper
: Paper in journal
Title: Inhibition of high affinity choline uptake in the rat
brain by neurotoxins: effect of monosialoganglioside GM1
- Authors:
- Maysinger, Dušica
- Leavitt, B.R.
- Zorc, Branka
- Butula, Ivan (6372)
- Fernandes, L.G.
- Ribeiro-da-Silva, A.
Journal: Neurochem.Int.
Number: 3
ISSN: 0197-0186
Volume: 20
Year: 1992
Pages: from 289 to 297
Number of references: 43
Language: engleski
Summary: Mustard derivatives of ethyl-choline and hemicholinium-3
havebeen suggested as possible specific cholinergic neurotoxins.
Astructural analog of hemicholinium-3 (toxin 7) was added tosynaptosomes
prepared from the cortex, striatum or hippocampus ofrat brain. HACU was
significantly decreased by addition of toxin7, while GABA or dopamine was
not changed. Incubation of corticalsynaptosomes with the GM1 prevented the
decrease in HACU. Twonewly synthesized hemicholinium-3 analogs (toxin 5 and
6) causeda larger decrease in HACU then toxin 7 and
ethyl-cholineaziridinium.
Keywords: neurotoxin, GM1, hemicholinium-3, HACU
- Type of paper
: Paper in journal
Title: á-Methyl-D-glucofururonohydroxamic acid, the first
sugar-hydroxamic acid and its iron(III) complexes in solution
- Authors:
- Uršić, Stanko (51201)
- Zorc, Branka
- Pilepić, Viktor
- Vikić-Topić, Dražen (71183)
Journal: Croat.Chem.Acta
Number: 4
ISSN: 0011-1643
Volume: 65
Year: 1992
Pages: from 851 to 857
Number of references: 16
Language: engleski
Summary: á-methyl-D-glucofuruonohydroxamic acid sodium salt
wassinthesized starting from gama-lactone ofá-methyl-D-glucofururonoside
and characterized by its physicalproperties and 13C NMR and IR spectral
data. Investigation of thecoordination ability of
á-methyl-D-glucofururonohydroxamic acidtoward the iron(III) in solution was
performed. The equilibriumquotients for the formation of iron(III) were
determined.
Keywords: sugar-hydroxamic acid, iron(III) complexes
- Type of paper
: Paper in journal
Title: Reactions of the carbonyl group with nitroso compounds.
The cases of pyruvic acid and acetaldehyde
- Authors:
- Uršić, Stanko (51201)
- Pilepić, Viktor
- Vrček, Valerije
- Gabričević, Mario
- Zorc, Branka
Journal: J.Chem.Soc.Perkin Trans.2
ISSN: 0002-7863
Year: 1993
Pages: from 509 to 514
Number of references: 42
Language: engleski
Summary: Pyruvic acid and acetaldehyde react with
substitutednitrosobenzenes to give the corresponding
N-phenylacetohydroxamicacids. A mechanism for these reactions involving
three sequentialsteps is proposed. The first step is nucleophilic attack of
thenitroso group on the carbonyl group, the second step is protontransfer,
and the last one is a decarboxylation.
Keywords: pyruvic acid, acetaldehyde, nitrosobenzene, N-phenylacetohydroxamic acid
- Type of paper
: Paper in journal
Title: Macromolecular prodrugs.II.Esters of L-dopa and
ŕ-methyldopa
- Authors:
- Zorc, Branka
- Ljubić, Maja
- Antolić, Siniša (176246)
- Filipović-Grčić, Jelena (136683)
- Maysinger, Dušica
- Alebić-Kolbah, Tanja
- Jalšenjak, Ivan
Journal: Int.J.Pharmac.
ISSN: 0378-5173
Volume: 99
Year: 1993
Pages: from 135 to 143
Number of references: 28
Language: engleski
Summary: L-Dopa and ŕ-methyldopa were attached by an ester linkage
toŕ,á-poly(N-hydroxyethyl)-DL-aspartamide (PHEA) by means
of1-benzotriazolylcarbonyl group. Release of the drugs based onhydrolysis
of PHEA adducts was studied in vitro. Characterizationof the PHEA-L-dopa
adduct was carried out in vivo using anintracerebral microdialysis
technique in order to evaluate theprolonged release eventually achieved. A
new method forpreparation of several simple esters of L-dopa and
ŕ-methyldopais described.
Keywords: polymeric prodrug, macromolecular carrier, ŕ,á-poly(N-hydroxyethyl)-DL-aspartamide, L-dopa ester, ŕ-methyldopa ester, 1-benzotriazolylcarbonyl group, microdialysis
- Type of paper
: Paper in journal
Title: QSPR and QSAR in pharmacy: I. Classical QSAR Models
(Hanschs and Free-Wilsons Model)
- Authors:
- Jadrijević-Mladar Takač, Milena (136694)
- Medić-Šarić, Marica (74265)
Journal: Farm.Glas.
Number: 6
ISSN: 014 -8202
Volume: 47
Year: 1991
Pages: from 161 to 178
Number of references: 60
Language: hrvatski
Summary: QSAR models are characterised by two assumptions with
respect tothe relationship between the chemical structure and thebiological
activity of a compound. The first is that one canderive quantitative
measure from the structure of those globaland local properties of
significance to the biological activityof a compound. The other assumption
is that one canmathematically describe the relationship between
biologicalproperty one wishes to optimize and the molecular
propertiescalculated from the structure. The most popular QSAR model is
thelinear free energy, extrathermodynamic or Hanschs model. In ourtimes
QSAR became a standard tool in drug design.
Keywords: drug design, Hanschs model, Free-Wilsons model, structure-activity relationship
- Type of paper
: Paper in journal
Title: Macromolecular prodrugs.I.Synthesis of nonsteroidal
anti-inflammatory drug esters
- Authors:
- Zorc, Branka
- Antolić, Siniša (176246)
- Butula, Ivan (6372)
Journal: Acta Pharm.
Number: 2
ISSN: 1330-0075
Volume: 43
Year: 1993
Pages: from 127 to 133
Number of references: 21
Language: engleski
Summary: A new method for the preparation of
nonsteroidalanti-inflammatory drug esters (ibuprofen, ketoprofen,
diclofenac,indomethacin) by means of 1-benzotriazole carboxylic
acidchloride is described. Beside simple alcohols in
esterificationreactions ŕ,á-poly(N-hydroxyethyl)-DL-aspartamide was
used.Release of active substances from the polymer-drug adducts invitro was
studied.
Keywords: nonsteroidal anti-inflammatory drug esters, prodrugs, ŕ,á-poly(N-hydroxyethyl)-DL-aspartamide, hydrolysis
- Type of paper
: Paper in journal
Title: Improvement of in vitro dissolution characteristics of
meclozine hydrochloride by cyclodextrin complexation
- Authors:
- Bećirević, Mira (2761)
- Senjković, Romana (42855)
Journal: Pharmazie
Number: 3
ISSN: 0031-7144
Volume: 47
Year: 1992
Pages: from 202 to 204
Number of references: 11
Language: engleski
Summary: The solid complexes of meclozine hydrochloride with CD in
1:1molar ratio were prepared by spray-drying. The dissolution ratesof
meclozine hydrochloride from the solid complexes were muchgreater than the
substance itself. The relative rate constantvalues increased in the order
of ŕ- < á- < gama-CD.
Keywords: meclozine, cyclodextrins, complexation
- Type of paper
: Paper in journal
Title: Effect of fillers on the properties of paracetamol and
acetylsalicylic acid tablets prepared by direct compression
- Authors:
- Senjković, Romana (42855)
- Bećirević, Mira (2761)
- Usmiani, Ivo
Journal: Pharm.Ind.
Number: 6
ISSN: 0031-711
Volume: 54
Year: 1992
Pages: from 555 to 557
Number of references: 13
Language: engleski
Summary: Tablets of paracetamol and acetylsalicylic acid were
prepared bydirect compression using different fillers: Ludipress, Avicel
PH102 and Granulatum simplex. Physico-chemical characteristics ofthe
products and the dissolution rates of the drugs from tabletswere analysed.
Keywords: paracetamol, acetylsalicylic acid, effect of fillers, direct compression
- Type of paper
: Paper in journal
Title: A convenient method for the preparation of
cis-3,4,8,8a-tetrahydro-6H-/1,3/-dioxepino/5,6-d/oxazoles
- Authors:
- Dumić, Miljenko (133202)
- Butula, Ivan (6372)
- Vinković, Mladen
- Kamenar, Boris
Journal: Org.Prep.Proced.Int.
Number: 5
ISSN: 0078-6160
Volume: 24
Year: 1992
Pages: from 536 to 539
Number of references: 6
Language: engleski
Summary: 3,4,8,8a-tetrahydro-6H-/1,3/-dioxepino/5,6-d/oxazoles
wereprepared by dehydrogenation of 6-acylamino-5-chloro-1,3-dioxepanein
ethanolic potassium hydroxide solution.
Keywords: cis-dioxepinooxazolines, 5.6-disubstituted-1.3-dioxepane
- Type of paper
: Paper in journal
Title: The synthesis of some B6 vitamin halophosphates
- Authors:
- Elshani, Sadik (139181)
- Butula, Ljubica (6383)
- Butula, Ivan (6372)
- Vikić-Topić, Dražen (71183)
- Berton, A
- Iriate, A
Journal: Croat.Chem.Acta
Number: 2
ISSN: 0011-1643
Volume: 64
Year: 1991
Pages: from 161 to 171
Number of references: 34
Language: engleski
Summary: A series of new halo-derivatives of pyridoxine-
andpyridoxal-3-O- or 5-O-phosphates have been synthetized. In thereaction
of partially protected pyridoxine and pyridoxal withphosphorusoxychloride
dichlorophosphates were obtained. Thesecompounds reacted with NaF under
catalytic action of18-crown-6-ether, giving the corresponding
difluorophosphates.The direct fluorination of pyridoxal-5-phospate
withdinitrofluorobenzene yielded pyridoxal-5-O-monofluorophosphate.
Keywords: B6 vitamin, halophosphates, fluorination
- Type of paper
: Paper in journal
Title: Synthesis and mitodepressive activity of some
phthalimidoalkanehydroxamic acids
- Authors:
- Matijević-Sosa, Julija (71850)
- Butula, Ljubica (6383)
Journal: Acta Pharm.
Number: 3
ISSN: 1330-0075
Volume: 43
Year: 1993
Pages: from 185 to 194
Number of references: 52
Language: engleski
Summary: Phthalimidoalkanehydroxamic acids were synthesized in
thereaction of N-phthaloyl-aminoacid chlorides with hydroxylamine.The
phytobiological tests were performed on Cresse seeds(Lepidium sativun L.).
Some of the examined compounds were foundto possess a significant
antimitotic activity.
Keywords: phthalimidohydroxamic acid, phytobiological test, antimitotic activity
- Type of paper
: Paper in journal
Title: Synthesis, physico-chemical properties and biochemical
significance of pyridoxal-5-fluorophosphate
- Authors:
- Butula, Ljubica (6383)
- Elshani, Sadik (139181)
- Fl”gel, Mirna (56805)
Journal: Acta Pharm.Jugosl.
ISSN: 1330-0075
Volume: 41
Year: 1991
Pages: from 1 to 6
Number of references: 19
Language: engleski
Summary: The synthesis of pyridoxal-5-fluorophosphate (PLPF) has
beenachieved starting from dinitrofluorobenzene and pyridoxalphosphate
(PLP) protected in the aldehyde region. PLFP as a PLPanalogue is an ideal
probe for structural studies ofcoenzyme-apoenzyme liganding, especially so
in the investigationof the phosphate binding region of the protein
molecule. Thereconstituted AST-PLFP enzyme shows a lower catalytic
activityand has a more tightly bound prostetic group in comparison withthe
natural holoenzyme.
Keywords: pyridoxal-5-fluorophosphate, pyridoxal phosphate, AST-PLFP
- Type of paper
: Paper in journal
Title: N- and O-methylated 3-(phthalimidoalkyl)-substituted
pyrazolin-5-ones
- Authors:
- Matijević-Sosa, Julija (71850)
- Butula, Ljubica (6383)
- Zambeli, Nevenka (54432)
Journal: Croat.Chem.Acta
Number: 2
ISSN: 0011-1643
Volume: 42
Year: 1992
Pages: from 139 to 151
Number of references: 20
Language: engleski
Summary: New 3-(phthalimidoalkyl)-substituted pyrazolin-5-ones
weresynthesized by cyclization of diethyl (gama-phthalimidoacyl)malonate
with methylhydrazine or hydrazine and by furthermethylation at positions 1,
2 or 5 of the ring with diazomethaneor methyl iodide.
Keywords: substituted pyrazolin-5-ones, diethyl (gama-phthalimidoacyl) malonate
- Type of paper
: Paper in journal
Title: A QSPR study of 3-(phthalimidoalkyl)-pyrazolin-5-ones
- Authors:
- Nikolić, Sonja
- Medić-Šarić, Marica (74265)
- Matijević-Sosa, Julija (71850)
Journal: Acta Pharm.
Number: 2
ISSN: 1330-0075
Volume: 42
Year: 1992
Pages: from 153 to 167
Number of references: 52
Language: engleski
Summary: Several QSPR models with topological indices are proposed
forpredicting physical properties of newly
prepared3-(phthalimidoalkyl)-pyrazolin-5-ones. The best QSPR models
wereobtained using Wiener index, the valence connectivity index, andmodels
based on combination of indices.
Keywords: 3-(phthalimidoalkyl)-pyrazolin-5-ones, QSPR models
- Type of paper
: Paper in journal
Title: Liposomes with clindamycin hydrochloride in the therapy of
Acne vulgaris
- Authors:
- Škalko, Nataša (34134)
- Čajkovac, Mira (7606)
- Jalšenjak, Ivan
Journal: Int.J.Pharmac.
ISSN: 0378-5173
Volume: 85
Year: 1992
Pages: from 97 to 101
Number of references: 20
Language: engleski
Summary: Liposomes with clindamycin hydrochloride were prepared
usingeither soya lecithin and cholesterol or hostaphate andcholesterol. In
vitro dissolution studies showed sustainedrelease of the drug from
hostphate liposomes compared to lechitinliposomes. Clinical treatment of
Acne vulgaris with a lotion ofliposomal drug shows better efficacy than
non-liposome lotionforms (esspecially of the treatment of pustules where
clinicalimprovement was 77 % of initial number).
Keywords: liposome, clindamycin hydrochloride, Acne vulgaris
- Type of paper
: Paper in journal
Title: Microspheres of human serum albumin with barbiturates:
effect of drug partition coefficient on preparation and drug release
- Authors:
- Filipović-Grčić, Jelena (136683)
- Jalšenjak, Ivan
Journal: J.Pharm.Pharmacol.
ISSN: 0022-3573
Volume: 45
Year: 1992
Pages: from 394 to 399
Number of references: 31
Language: engleski
Summary: The total drug content of microspheres was dependent on
thepartition coefficient and an increase in the partitioncoefficient caused
a decrease in the drug content of finishedmicrospheres due to drug
migration to the outer organic phase.The ensemble drug release from
microspheres was followed by thepaddle method and by potentiometric
titration with a pH-stat.Spherical Higuchi equation, especially biphasic
first orderkinetics, gave the best fit for the release.
Keywords: human serum albumin, barbiturates, partition coefficient, microspheres, drug release
- Type of paper
: Paper in journal
Title: Microencapsulated nerve growth factor: effects on the
forebrain neurons following devascularizing cortical lesions
- Authors:
- Maysinger, Dušica
- Jalšenjak, Ivan
- Cuello, Claudio
Journal: Neuroscience Lett.
ISSN: 0733-2467
Volume: 140
Year: 1992
Pages: from 71 to 74
Number of references: 20
Language: engleski
Summary: The effectiveness of NGF incorporated in the
biodegradablemicrospheres was investigated in the rat model for
centralcholinergic degeneration. Choline acetyltransferase activity
wasmeasured in the nucleus basalis magnocellularis and cortex foranimals
treated with empty microspheres and NGF containingmicrospheres. The results
stress the experimental therapeuticpossibilities of novel delivery systems
for administration oftrophic factors in the CNS.
Keywords: microencapsulation, microsphere, choline acetyltransferase, cholinergic neuron
- Type of paper
: Paper in journal
Title: Influence of emulsoid vehicle on the release and activity
of allantoin
- Authors:
- Čajkovac, Mira (7606)
- Oremović, Lenka
- Čajkovac, Vladimir (2799)
Journal: Pharmazie
Number: 1
ISSN: 0031-7144
Volume: 47
Year: 1992
Pages: from 39 to 43
Number of references: 16
Language: engleski
Summary: The influence of various emulsified vehicles on releasing
anddiffusion of allantoin through semipermeable membrane in vitro.While the
vehicle emulsified with a complex Tagat S - Tegin Mgave the best results in
vitro, lanacolic vehicle gave clinicallythe best results.
Keywords: allantoin, emulsified vehicles, psoriasis
- Type of paper
: Paper in journal
Title: Influence of vehicle on antimicrobial efficiency of
topical dosage forms of neomycin sulphate
- Authors:
- Čajkovac, Mira (7606)
- Božulić, Ante
- Kosi, Emina
Journal: Acta Pharm.
Number: 1
ISSN: 1330-0075
Volume: 43
Year: 1993
Pages: from 51 to 58
Number of references: 10
Language: engleski
Summary: The influence of various emulsified and non-emulsified
bases onthe release and stability of neomycin sulphate was investigatedby
means of microbiological method. The best results are obtainedwith neomycin
sulphate in a non-ionogenic ambiphilic basis of theO/W type, and then drug
release was better than for a commertialpreparations.
Keywords: neomycin sulphate, release and stability, non-ionogenic ambiphilic basis
- Type of paper
: Paper in journal
Title: Active ingredients in local dermatotherapy
- Authors:
- Čajkovac, Mira (7606)
- Čajkovac, Vladimir (2799)
Journal: Farm.Glas.
Number: 3
ISSN: 0014-8202
Volume: 48
Year: 1992
Pages: from 73 to 84
Number of references: 28
Language: hrvatski
Summary: A spectrum of most often used active ingredients in the
localdermatotherapy is described and a brief comment about theiractivities
is added, side-effects as well as possibilities oftheir substitution in the
case of allergic manifestations arementioned.
Keywords: dermatotherapy, active ingredients, allergy
- Type of paper
: Paper in journal
Title: Direct compression for tabletes producing
- Authors:
- Pulišić, Marina
- Senjković, Romana (42855)
Journal: Farm.Glas.
Number: 6
ISSN: 0014-8202
Volume: 49
Year: 1993
Pages: from 167 to 176
Number of references: 28
Language: hrvatski
Summary: Advantages and disadvantages of direct compression for
producingtablets are reviewed. Properties of additives used
andcharacteristics of tablets prepared are discused.
Keywords: tablets, direct compresion, additives
- Type of paper
: Paper in journal
Title: Microencapsulation of genetically engineered fibroblasts
secreting nerve growth factor
- Authors:
- Maysinger, Dušica
- Piccardo, P.
- Filipović-Grčić, Jelena (136683)
- Cuello, Claudio
Journal: Neurochem.Int.
Number: 2
ISSN: 0197-0186
Volume: 23
Year: 1993
Pages: from 123 to 129
Number of references: 37
Language: engleski
Summary: Genetically modified fibroblasts were encapsulated
intoalginate-polylysine spheres retaining their viability andcapacity to
secrete biologically active nerve growth factor forat least 60 days.
Keywords: microspheres, nerve growth factor, fibroblasts
- Type of paper
: Paper in journal
Title: Effects of coencapsulated NGF and GM1 in rats with
cortical lesions
- Authors:
- Maysinger, Dušica
- Filipović-Grčić, Jelena (136683)
- Cuello, Claudio
Journal: Neuro Report
Number: 7
ISSN: 0959-4965
Volume: 4
Year: 1993
Pages: from 971 to 974
Number of references: 25
Language: engleski
Summary: Nerve growth factor and monosialoganglioside
weremicroencapsulated in poly(L-lactide):co-glycolide andadministered
locally to rats with unilateral corticaldevascularizing lesions.
Biochemical and quantitativeimmunocytochemical analyses revealed effective
protection fromdegenerative changes of NBM cholinergic neurones and
asignificant increase in choline acetyltransferase activity.
Keywords: coencapsulation, neurotrophin delivery, nerve growth factor, cholinergic system, ichaemic lesion, monosialoganglioside GM1
- Type of paper
: Paper in journal
Title: A QSPR study of 3-(phthalimidoalkyl)-pyrazolin-5-ones
- Authors:
- Nikolić, Sonja
- Medić-Šarić, Marica (74265)
- Matijević-Sosa, Julija (71850)
Journal: Croat.Chem.Acta
Number: 1
ISSN: 0011-1643
Volume: 66
Year: 1993
Pages: from 151 to 160
Number of references: 31
Language: engleski
Summary: A group og 3-(phthalimidoalkyl)-pyrazolin-5-ones were
tested fortheir mitodepressive activity upon the growth of Lepidum
sativumL. Four topological indices were used in QSAR studies. The
QSARmodels can predict cytostatic activity on the HeLa cells.
Keywords: 3-(phthalimidoalkyl)-pyrazolin-5-ones, QSAR models, mitodepressive activity
- Type of paper
: Summary in proceedings
Title: Synthesis and reactivity of 1-indazole carboxylic acid
derivatives
- Authors:
- Butula, Ivan (6372)
- Zorc, Branka
Proceedings title: Sinopsisi
Language: hrvatski
Place: Zagreb
Year: 1991
Pages: from 119 to 119
Meeting: XII. Sastanak kemičara Hrvatske
Held: from 02/11/91 to 02/13/91
- Type of paper
: Summary in proceedings
Title: Application of molecular modelling techniques in
investigation of new synthetized phthalimido-pyrazoles
- Authors:
- Medić-Šarić, Marica (74265)
- Matijević-Sosa, Julija (71850)
- Talaja, Jasna
Proceedings title: Sinopsisi
Language: hrvatski
Place: Zagreb
Year: 1991
Pages: from 77 to 77
Meeting: XII. Sastanak kemičara Hrvatske
Held: from 02/11/91 to 02/13/91
- Type of paper
: Summary in proceedings
Title: A QSAR study of 3-(phthalimidoalkyl)-pyrazolin-5-ones
- Authors:
- Medić-Šarić, Marica (74265)
- Nikolić, Sonja
- Matijević-Sosa, Julija (71850)
Proceedings title: Abstracts and list of participants
Language: engleski
Place: Rovinj, Hrvatska
Year: 1992
Pages: from 0 to 0
Meeting: The seventh international course and conference on the interface between mathematics, chemistry and computer science
Held: from 06/22/92 to 06/26/92
- Type of paper
: Summary in proceedings
Title: QSAR study of phthalimido-hydroxamic acids
- Authors:
- Nikolić, Sonja
- Medić-Šarić, Marica (74265)
- Matijević-Sosa, Julija (71850)
- Ivaniš, Sanja
Proceedings title: Book of abstracts & list of participants
Language: engleski
Place: Rovinj, Hrvatska
Year: 1993
Pages: from 0 to 0
Meeting: The eight international course & conference interfaces among mathematics, chemistry & computer sciences
Held: from 06/21/93 to 06/25/93
- Type of paper
: Summary in proceedings
Title: The reactions of nitro-oximino-1,3-dioksepina
- Authors:
- Jadrijević-Mladar Takač, Milena (136694)
- Dumić, Miljenko (133202)
- Butula, Ivan (6372)
Proceedings title: Sinopsisi
Language: hrvatski
Place: Zagreb
Year: 1991
Pages: from 118 to 118
Meeting: XII. Sastanak kemičara Hrvatske
Held: from 02/11/91 to 02/13/91
- Type of paper
: Summary in proceedings
Title: Synthesis of some nonsteroidal anti-inflammatory drug
esters
- Authors:
- Zorc, Branka
- Antolić, Siniša (176246)
- Butula, Ivan (6372)
Proceedings title: Sinopsisi
Language: hrvatski
Place: Zagreb
Year: 1993
Pages: from 125 to 125
Meeting: XIII. Skup hrvatskih kemičara
Held: from 02/08/93 to 02/10/93
- Type of paper
: Summary in proceedings
Title: Polymeric prodrugs of L-dopa and ŕ-methyldopa
- Authors:
- Zorc, Branka
- Ljubić, Maja
- Antolić, Siniša (176246)
- Filipović-Grčić, Jelena (136683)
- Butula, Ivan (6372)
- Jalšenjak, Ivan
Proceedings title: Sinopsisi
Language: hrvatski
Place: Zagreb
Year: 1993
Pages: from 126 to 126
Meeting: XIII. Skup hrvatskih kemičara
Held: from 02/08/93 to 02/10/93
- Type of paper
: Summary in proceedings
Title: Synhtesis and reactions of nitro-oximino-bis-1,3-dioxepine
- Authors:
- Jadrijević-Mladar Takač, Milena (136694)
- Butula, Ivan (6372)
- Vikić-Topić, Dražen
- Dumić, Miljenko (133202)
Proceedings title: Sinopsisi
Language: hrvatski
Place: Zagreb
Year: 1993
Pages: from 116 to 116
Meeting: XIII. Skup hrvatskih kemičara
Held: from 02/08/93 to 02/10/93
- Type of paper
: Summary in proceedings
Title: Prodrugs of fenoprofen and probenecid
- Authors:
- Zorc, Branka
- Butula, Ivan (6372)
Proceedings title: Sinopsisi radova
Language: hrvatski
Place: Bizovačke toplice, Hrvatska
Year: 1993
Pages: from 56 to 56
Meeting: 7. Ružičkini dani
Held: from 09/23/93 to 09/24/93
- Type of paper
: Summary in proceedings
Title: Application of x-ray structural analysis to the
determination of constitution, configuration and conformation of
1,3-dioxepins
- Authors:
- Dumić, Miljenko (133202)
- Filić, Darko
- Vinković, Mladen
- Butula, Ivan (6372)
- Matak, Dijana
- Kamenar, Boris
Proceedings title: Sinopsisi radova
Language: hrvatski
Place: Bizovačke toplice, Hrvatska
Year: 1993
Pages: from 30 to 30
Meeting: 7. Ružičkini dani
Held: from 09/23/93 to 09/24/93
- Type of paper
: Summary in proceedings
Title: The determination of Beckmann rearrangement products of
4,7-dihydro-5-nitro-4-oximino-1,3-dioxepine by spectroscopic methods
- Authors:
- Jadrijević-Mladar Takač, Milena (136694)
- Vikić-Topić, Dražen
- Vinković, Mladen
- Dumić, Miljenko (133202)
- Butula, Ivan (6372)
- Kamenar, Boris
Proceedings title: Book of abstracts
Language: hrvatski
Place: Zagreb
Year: 1991
Pages: from 334 to 334
Meeting: 20. European congress on molecular spectroscopy
Held: from 08/25/91 to 08/30/91
- Type of paper
: Summary in proceedings
Title: Polymeric prodrugs of broxuridine
- Authors:
- Zorc, Branka
- Kalčić, Igor
- Butula, Ivan (6372)
Proceedings title: European Journal of Pharmaceutical Sciences
Language: engleski
Place: Berlin, Njemačka
Year: 1994
Pages: from 144 to 144
Meeting: 2nd European Congress of Pharmaceutical Sciences
Held: from 09/28/94 to 10/01/94
- Type of paper
: Summary in proceedings
Title: Intermedijaates in sinthesys of fluoroketoprofen
derivatives
- Authors:
- Zorc, Branka
- Kalčić, Igor
- Vikić-Topić, Dražen
- Butula, Ivan (6372)
Proceedings title: XIV. Skup hrvatskih kemičara
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 12 to 12
Meeting: XIV. Sastanak hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
- Type of paper
: Summary in proceedings
Title: Synthesis and hydrolysis of ketoprofene-5'-pyridoxyl ester
- Authors:
- Dumić, Miljenko (133202)
- Mikulić, Romana
- Zorc, Branka
- Butula, Ivan (6372)
Proceedings title: XIV. Skup hrvatskih kemičara
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 16 to 16
Meeting: XIV. Sastanak hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
- Type of paper
: Summary in proceedings
Title: Polyhydroxamic acids - synthesis and iron(III) complexes
- Authors:
- Jakopović, Maja
- Zorc, Branka
- Biruš, Mladen
- Butula, Ivan (6372)
Proceedings title: XIV. Skup hrvatskih kemičara
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 25 to 25
Meeting: XIV. Sastanak hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
- Type of paper
: Summary in proceedings
Title: Synthesis of some aminoacids N-hydroxiamino derivatives
- Authors:
- Mushkolaj, Ilirijana
- Matijević-Sosa, Julija (71850)
- Butula, Ivan (6372)
Proceedings title: XIX. Skup hrvatskih kemičara
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 182 to 182
Meeting: XIV. Sastanak hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
- Type of paper
: Summary in proceedings
Title: Polymeric prodrug of dopamine
- Authors:
- Kalčić, Igor
- Zorc, Branka
- Butula, Ivan (6372)
Proceedings title: 55th World Congress of Pharmacy and Pharmaceutical Sciences
Language: engleski
Place: Stockholm, Sweden
Year: 1995
Pages: from 123 to 123
Meeting: 55th World Congress of Pharmacy and Pharmaceutical Sciences
Held: from 08/27/95 to 09/01/95
- Type of paper
: Summary in proceedings
Title: Synthesis of some Aminoacids N-hydroxyamino derivatives
- Authors:
- Mushkolaj, Ilirijana
- Matijević-Sosa, Julija (71850)
- Butula, Ivan (6372)
Proceedings title: XIV. Skup hrvatskih kemičara
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 100 to 100
Meeting: XIV. Sastanak hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
- Type of paper
: Summary in proceedings
Title: Relationships between the Properties and Topological
Indices of the New Synthesized Phthalimidoisoxasolones
- Authors:
- Medić-Šarić, Marica (74265)
- Matijević-Sosa, Julija (71850)
- Nikolić, Sonja
Proceedings title: XIV. Skup hrvatskih kemičara
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 122 to 122
Meeting: XIV. Sastanak hrvatskih kemičara
Held: from 02/06/95 to 02/08/95
- Type of paper
: Summary in proceedings
Title: A Comparative study of lipophilicity and biological
activity of 4-(Phthalimidoalkyl)-Pyrazolin-5-ones
- Authors:
- Nikolić, Sonja
- Medić-Šarić, Marica (74265)
- Matijević-Sosa, Julija (71850)
Language: engleski
Place: Lausanne, Switzerland
Year: 1995
Meeting: An International Symposium on Lipophilicity in Drug Research and Toxicology
Held: from 03/21/95 to 03/24/95
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Čajkovac, Mira (7606)
- Oremović, Lenka
Proceedings title: Zbornik radova I.Skupa HDKK i biomedicinski aspekti kozmetike
Language: hrvatski
Place: Opatija
Year: 1993
Pages: from 170 to 176
Meeting: I. Skup HDKK
Held: from 10/13/93 to 10/15/93
- Type of paper
: Summary in proceedings
Title:
- Authors:
- Cvetnić, Zdenka
- Pepeljnjak, Stjepan
- Čajkovac, Mira (7606)
Proceedings title: Zbornik radova stručnih dana HDKK: od kontrole kvalitete do cjelokupnog upravlja
Language: hrvatski
Place: Zagreb
Year: 1995
Meeting: Stručni dani HDKK
Held: from 05/16/95 to 05/18/95
- Type of paper
: Summary in proceedings
Title: Liposomes in cosmetics: present and future
- Authors:
- Škalko, Nataša (34134)
- Čajkovac, Mira (7606)
Proceedings title: Zbornik radova stručnih dana HDKK: od kontrole kvalitete do cjelokupnog upravlja
Language: hrvatski
Place: Zagreb
Year: 1995
Pages: from 39 to 39
Meeting: Stručni dani HDKK
Held: from 05/16/95 to 05/18/95
- Type of paper
: Summary in proceedings
Title: Microfluidized liposomes with surface-linked protein:
Characterization and immunological studies
- Authors:
- Škalko, Nataša (34134)
- Bouwstra, Joke
- Gregoriadis, Gregory
Proceedings title: Fourth Liposome Research Days Conference
Language: engleski
Place: Freiburg, Njemačka
Year: 1995
Pages: from 61 to 61
Meeting: Fourth Liposome Research Days Conference
Held: from 08/30/95 to 09/02/95
- Type of paper
: Summary in proceedings
Title: Inclusion of nifedipine or nifedipine-cyclodextrine
complexes into microspheres and liposomes
- Authors:
- Škalko, Nataša (34134)
- Filipović-Grčić, Jelena (136683)
- Bećirević, Mira (2761)
- Jalšenjak, Ivan
Proceedings title: Farmacevtski Vestnik
Language: engleski
Place: Ljubljana, Slovenija
Year: 1995
Meeting: 1st Central European Symposium on Pharmaceutical Technology
Held: from 10/18/95 to 10/20/95
- Type of paper
: Summary in proceedings
Title: Use video in continuing education of farmacists in primary
health care
- Authors:
- Jadrijević-Mladar Takač, Milena (136694)
Proceedings title: Abstracts Book: 55th World Congress of Pharacy and Pharmaceutical Sciences
Language: engleski
Place: Stockholm, Sweden
Year: 1995
Meeting: 55th World Congress of Pharmacy and Pharmaceutical Sciences
Held: from 08/27/95 to 09/01/95
- Type of paper
: Summary in proceedings
Title: The effect of microfluidization of multilamellar liposomes
on the surface exposure o a protein covalently linked to the bilayer
- Authors:
- Škalko, Nataša (34134)
- Gregoriadis, Gregory
Proceedings title: 1st Annual UKAPS Conforence
Language: engleski
Place: York, Engleska
Year: 1992
Pages: from 24 to 24
Meeting: 1st Annual UKAPS Conference
Held: from 04/12/92 to 04/14/92
- Type of paper
: Summary in proceedings
Title: Protein exposure on the liposomal surface after vesicle
size reduction
- Authors:
- Škalko, Nataša (34134)
- Gregoriadis, Gregory
Proceedings title: Journal of Liposome Research
Language: engleski
Place: New York, USA
Year: 1992
Pages: from 157 to 158
Meeting: 2nd Liposome Research Days
Held: from 06/20/92 to 06/22/92
- Type of paper
: Summary in proceedings
Title: The effect of microfluidization of liposomes on the
localization of surface linked ligands
- Authors:
- Škalko, Nataša (34134)
- Gregoriadis, Gregory
Proceedings title: 8th Liposome Workshop
Language: engleski
Place: Oberjoch, Njemačka
Year: 1993
Pages: from 37 to 37
Meeting: 8th Liposome Workshop, Oberjoch
Held: from 04/07/93 to 04/11/93
- Type of paper
: Summary in proceedings
Title: Localization of protein on liposomal surface: the effect
of microfluidization
- Authors:
- Škalko, Nataša (34134)
- Gregoriadis, Gregory
- Bouwstra, Joke
- Spies, Ferry
Proceedings title: Liposome in Drug Delivery
Language: engleski
Place: London, United Kingdom
Year: 1993
Pages: from 45 to 45
Meeting: The nineties and beyond
Held: from 12/09/93 to 12/13/93
- Type of paper
: Summary in proceedings
Title: Vesicle (niosome)-in-water-in-oil dispersion: their
potential use in drug and vaccine delivery
- Authors:
- Florence, Alexander T.
- Gregoriadis, Gregory
- Škalko, Nataša (34134)
- Yoshioka, Toshimitsu
- Gursel, Mayda
Proceedings title: Liposome in Drug Delivery
Language: engleski
Place: London, United Kingdom
Year: 1993
Pages: from 25 to 25
Meeting: The nineties and beyond
Held: from 12/09/93 to 12/13/93
- Type of paper
: Prototype
Title: Arylalkanoic acid esters with antiinflammatoric activity
and method for their synthesis
- Authors:
- Butula, Ivan (6372)
- Zorc, Branka
Institution of application: Državni zavod za patente Republike Hrvatske
Date of application: 07/06/93
Registration number of application: 3810393013468
Countries in which it is protected: RH
Language: hrvatski
Summary: A new method for preparation of nonsteroidal
antiinflammatorydrug esters (ibuprofen, ketoprofen, diclofenac, and
indomethacin)by means of 1-benzotriazole carboxylic acid chloride
isdescribed. The same drugs are attached on a hydrosoluble,biodegradable
polymer ŕ,á-poly(2-hydroxyethyl)-D,L-aspartamide.The polymer-drug
conjugates are potential prodrugs.
Keywords: arylalkanoic acids esters, nonsteroidal antiinflammatory drugs, polymeric prodrugs, ŕ,á-poli(2-hydroxyethyl)-D,L-aspartamide
- Type of paper
: Prototype
Title: L-dopa and ŕ-methyldopa esters and method for their
preparation
- Authors:
- Butula, Ivan (6372)
- Zorc, Branka
Institution of application: Državni zavod za patente Republike Hrvatske
Date of application: 07/16/93
Registration number of application: 3810393013647
Countries in which it is protected: RH
Language: hrvatski
Summary: A new method for L-dopa and ŕ-methyldopa esters preparation
isdescribed. Antiparkinsonic drug L-dopa and antihypertensive
drugŕ-methyldopa are also attached
toŕ,á-poly(2-hydroxyethyl)-D,L-aspartamide. Preparation andcharacteristics
of the polymer-drug conjugates as potentialprodrugs are described.
Keywords: L-dopa, ŕ-methyldopa, esters, polymeric prodrugs, ŕ,á-poli(2-hydroxyethyl)-D,L-aspartamide
- Type of paper
: Prototype
Title: Polyhydroxamic acids -
poly(ŕ,á-(N-hydroxyethyl-DL-aspartamide)) derivatives (properties and
preparation)
- Authors:
- Butula, Ivan (6372)
- Jakopović, Maja
- Zorc, Branka
Institution of application: Državni zavod za patente Republike Hrvatske
Date of application: 03/31/95
Registration number of application: P950180A
Countries in which it is protected: Hrvatska
Language: hrvatski
Summary: Synthesis of different polyhydroxamic acids -
poly(ŕ,á-(N-hydroxy-DL-aspartamide)) derivatives is described. These
polyhydroxamic acids were prepared by the reaction of hydroxylamine RNHOH
or amine R1H with polysuccinimide with different average relative molecular
mass in dry DMF at room temperature through several hours to several days.
Keywords: polyhydroxamic acids, poly(ŕ,á-(N-hydroxy-DL-aspartamide)), polysuccinimide
- Type of paper
: Ph.D.
Title: Biocompatible microspheres of neurotrophics factors
Faculty: Farmaceutsko-biokemijski fakultet Sveučilište u Zagrebu
Author: FILIPOVIĆ-GRČIĆ JELENA
Date of defense: 07/02/93
Language: hrvatski
Number of pages: 105
Summary: Results of these studies strongly suggest that
coencapsulation oftwo different neuroprotective factors into biodegradable
polymersmay be used as a novel mean for delivery of these agents into
theCNS. It was also demonstrated that genetically modifiedfibroblasts can
be encapsulated into biocompatible, biodegradablespheres retaining their
viability and capacity to continouslysecrete nerve growth factors for at
least two months. Nervegrowth factor (NGF) and monosialoganglioside (GM1)
weremicroencapsulated in copolymer of lactic and glycolic acid,tested in
vitro and in selective experiments in vivo in animalswith unilateral
cortical devascularizing lesions.
Keywords: copolymer of lactic and glycolic acid, microspheres, GM1, NGF, rat fibroblasts
- Type of paper
: Ph.D.
Title: The effect of microfluidization on liposomal surface
protein: characterisation and immunological studies
Faculty: The School of Pharmacy University of London
Author: ŠKALKO NATAŠA
Date of defense: 11/23/94
Language: engleski
Number of pages: 228
- Type of paper
: Ph.D.
Title: Priprava, transformacije i primjena 1,3-dioksepinskih
dienofila u sintezi piridoksina
Faculty: Farmaceutsko-biokemijski fakultet Sveučilište u Zagrebu
Author: JADRIJEVIĆ-MLADAR-TAKAČ MILENA
Date of defense: 07/18/94
Language: hrvatski
Number of pages: 166
- Type of paper
: Ph.D.
Title: Potential submicron particulate carriers: preparation and
surface modification with amphipathic copolymers
Faculty: Farmaceutsko-biokemijski fakultet Sveučilište u Zagrebu
Author: STOLNIK SNJEŽANA
Date of defense: 06/02/94
Language: engleski
Number of pages: 217
- Type of paper
: M.A.
Title: The attachment of arylalkanoic acids to the
ŕ,á-poly/(2-hydroxyethyl)-D,L-aspartamid/ and kinetic of hydrolysis
Faculty: Postdiplomski studij prirodnih znanosti Sveučilište u Zagrebu
Date of defense: 07/09/93
Language: hrvatski
Number of pages: 147
Summary: A new method for preparation of non-steroidal
antiinflammatorydrug esters and ŕ-methyldopa esters by means of
1-benzotriazolecarboxilic acid chloride (BtcCl) was described. BtcCl
reactedwith the carboxylic functional group in the drugs formingreactive
benzotriazolides. Benzotriazolides with hydroxycompounds gave the
corresponding esters. In the case ofŕ-methyldopa Btc served as an
N-protecting and C-activatinggroup. In the reactions of esterification
simple alcohols andŕ,á-poly(2-hydroxyethyl)-D,L-aspartamide were used.
Release ofactive substances from polymer-drug conjugates was studied
invitro.
Keywords: ŕ,á-poly(2-hydroxyethyl)-D,L-aspartamid, non-steroidal antiinflammatory drugs, ŕ-methyldopa, 1-benzotriazolylcarbonyl, arylalkanoic acids esters, macromolecular carrier, hydrolysis
- Type of paper
: M.A.
Title: Release of drugs from albumin microspheres
Faculty: Farmaceutsko-biokemijski fakultet Sveučilište u Zagrebu
Author: FILIPOVIĆ-GRČIĆ JELENA
Date of defense: 05/24/91
Language: hrvatski
Number of pages: 136
- Type of paper
: Mentorship
Title: Synthesis and reactions of N-(1-azolylcarbonyl)-aminoacids
Faculty: Postdiplomski studij prirodnih znanosti Sveučilište u Zagrebu
Mentor: BUTULA IVAN
Date of defense: 11/24/93
Number of pages: 159
Author: Mushkolaj dipl.inž. Ilirijana
Degree level: M.A.
- Type of paper
: Mentorship
Title: Influence of membrane crosslinking on microcapsule
permeability
Faculty: Farmaceutsko-biokemijski fakultet Sveučilište u Zagrebu
Mentor: JALŠENJAK IVAN
Date of defense: 11/09/93
Number of pages: 110
Author: Takač mr Darko
Degree level: M.A.
- Type of paper
: Mentorship
Title:
Faculty: Farmaceutsko-biokemijski fakultet Sveučilište u Zagrebu
Mentor: DUMIĆ MILJENKO
Date of defense: 07/15/94
Number of pages: 166
Author: Jadrijević-Mladar Takač mr Milena
Degree level: Ph.D.
- Type of paper
: Mentorship
Title: Biocompatible microspheres with neurotrophic factors
Faculty: Farmaceutsko-biokemijski fakultet Sveučilište u Zagrebu
Mentor: JALŠENJAK IVAN
Date of defense: 07/02/93
Number of pages: 105
Author: Filipović-Grčić dr Jelena
Degree level: Ph.D.
- Type of paper
: Mentorship
Title: Kinetic of the drug release from albumin microspheres
Faculty: Farmaceutsko-biokemijski fakultet Sveučilište u Zagrebu
Mentor: JALŠENJAK IVAN
Date of defense: 05/24/91
Number of pages: 136
Author: Filipović-Grčić dr Jelena
Degree level: M.A.
