SVIBOR - Project code: 4-07-032

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 4-07-032


BIOTRANSFORMATIONS/BIOREACTORS


Main researcher: VASIĆ-RAČKI, ĐURĐA (51631)


Assistants
Type of research: basic
Duration from: 04/30/91. to 12/31/93.
Papers on project (total): 22
Papers on project quoted in Current Contents: 3
Institution name: Fakultet kemijskog inženjerstva i tehnologije, Zagreb (125)
Department/Institute: Department for reaction engineering and catalysis
Address: Savska c. 16
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (041) 272-318
Summary: The aim of biotransformation research is to develop the continuous processes to produce some industrial important compounds. The chemical engineering concept in biotransformations research was to design optimal bioreactor for this purpose, by integration of biotransformation, biocatalyst and bioreactor type. The biotransformations catalyzed by soluble-immobilized as well as immobilized biocatalysts were studied. The following topics were investigated: - the bioreactor with immobilized glucose isomerase - the kinetics of enzyme oil hydrolyse and esterification of oleic acid in enzyme membrane reactor - the synthesis of L-terc.leucin in enzyme membrane reactor - the enantioselective oxido-reduction catalyzed by enzyme. The separation of glucose/fructose mixture which could be integrated with glucose isomerization was studied. The immobilized glucose isomerase wholle cellls were prepared. The production of glucose isomerase as well as production of alcohol dehydrogenase are currently investigated.

Keywords: Biotransformations, bioreactors, biocatalysts, enzymes, enzymatic isomerization of glucose, enzymatic hydrolysis of oil, enzymatic esterification of oleic acids, selective enzymatic oxido-reductions, glucose isomerase, lipase, leucine dehydrogenase, alcohol dehydrogenase.

Research goals: The goals of the BIOTRANSFORMATIONS/BIOREACTORS research have been development and optimization of continuous processes catalyzed by biocatalysts as well as the production process of the biocatalysts. The project results throw more light on the fundamental technical knowledge on the core of the biotechnological process and the biocatalyst production process itself. This knowledge can be applied in chemical as well as in faramaceutical industry.

COOPERATION - PROJECTS


  1. Name of project: 6K0A2A Theoretische Modelle fuer Reaktionen von Enzymen (Theoretical Models of Reactions catalyzed by Enzymes)
    Name of institution: Insitut fuer Biotechnologie - Forschungszentrum Juelich BRD

  2. Name of project: 6K0A2A Theoretische Modelle fr Reaktionen von Enzymen (Theoretical Models of Reactions Catalyzed by Enzymes)
    Name of institution: Institut fr Biotechnologie-Forschungszentrum
    City: Jlich, Deutschland

  3. Name of project: 6K0A2A Theoretische Modelle fr Reaktionen von Enzymen (Thoretical Models of Reactions Catalyzed by Enzymen)
    Name of institution: Institut fr Biotechnologie - Forschungszentrum Jlich
    City: Jlich, Deutschland

COOPERATION - INSTITUTIONS


  1. Name of institution: Insitut fuer Biotechnologie 2 - Forschungszentrum Juelich - BRD
    Type of institution: University/Faculty
    City: Juelich, Deutschland

  2. Name of institution: Institut fr Biotechnologie 2 - Forschungszentrum Jlich
    Type of institution: University/Faculty
    City: Jlich, Deutschland

  3. Name of institution: Institut fr Biotechnologie 2 - Forschungszentrum Jlich
    Type of institution: University/Faculty
    City: Jlich, Deutschland
Other information about the project.
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Last update: 02/25/94
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