SVIBOR - Project code: 1-07-192

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

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Project code: 1-07-192


SYNTHESIS AND PROPERTIES OF BIOACTIVE GLYCOCONJUGATES


Main researcher: HORVAT, ŠTEFICA (51440)


Assistants
Type of research: basic
Duration from: 01/01/91. to 12/31/93.
Papers on project (total): 69
Papers on project quoted in Current Contents: 27
Institution name: Institut "Ruđer Bošković", Zagreb (98)
Department/Institute: Department of Organic Chemistry and Biochemistry
Address: Bijenička 54
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (1)-424-868
E-mail: jhorvat2olimp.irb.hr
Summary: New biologically active compounds or their complexes belonging to the class of monosaccharides, oligosaccharides, peptides and glycopeptides were synthesized, or isolated from biological sources, and their physico-chemical and biological properties examined. The following lines of investigation were pursued: 1) synthesis and bioevaluation of glycoconjugates in which enkephalins, endogenous opioid peptides, or some other biologically active molecules, were coupled to free or protected carbohydrates, 2) synthesis and conformational analysis of muramic acid delta-lactam structures characteristic of bacterial spore peptidoglycan units, 3) pharmacokinetics of 14-C labeled immunomodulator peptidoglycan monomer after intravenous administration in mice.

Keywords: monosaccharides, oligosaccharides, peptides, glycopeptides, glycoconjugates, enkephalins, peptidoglycan, bacterial spores

Research goals: The objective of the proposed research is synthesis (or isolation from biological materials) of well-defined biologically active compounds belonging to the class of sugars, peptides and glycopeptides, which will provide information about structure and reactivity relationships. Information of this kind should be relevant to better understanding of some natural events or for the design of carbohydrate-peptide based drugs. New synthetic approaches to carbohydrate derivatives of enkephalins, endogenous opioid pentapeptides, as a new class of compounds of low toxicity with probable immunomodulatory, anti-viral or anti-tumor activity will be studied. In order to gain an insight into biological events leading from bacterium to spore transformation, muramic acid delta-lactam related structures will be synthesized and their conformation studied. To explain the immunomodulatory activity of peptidoglycan monomer, bacterial cell-wall constituent, pharmacokinetics in mice after intravenous administration will be studied.

COOPERATION - PROJECTS


  1. Name of project: 1-07-179 Odnos strukture i kemijskih te bioloških svojstava molekula
    Name of institution: Institut Ruđer Bošković
    City: 10000 - Zagreb, Croatia

  2. Name of project: 1-07-194 Istraživanje strukture peptida i glikopeptida u otopini
    Name of institution: Institut Ruđer Bošković
    City: 10000 - Zagreb, Croatia

  3. Name of project: 1-07-195 Struktura i funkcija biljnih indola
    Name of institution: Institut Ruđer Bošković
    City: 10000 - Zagreb, Croatia

  4. Name of project: 1-08-151 Modifikatori biološkog odgovora - mehanizam djelovanja
    Name of institution: Institut Ruđer Bošković
    City: 10000 - Zagreb, Croatia

  5. Name of project: 1-08-144 Ekspresija i uloga onkogena i faktora rasta u malignim tumorima
    Name of institution: Institut Ruđer Bošković
    City: 10000 - Zagreb, Croatia

COOPERATION - INSTITUTIONS


  1. Name of institution: Arizona State University, Cancer Research Institute
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Tempe, Arizona, SAD

  2. Name of institution: Chemotherapeutisches Forschungsinstitut Georg-Speyer Haus
    Type of institution: State institute
    Type of cooperation: Joint publishing of scientific papers
    City: Frankfurt, Njemačka

  3. Name of institution: Imunološi zavod
    Type of institution: Economical/Production
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  4. Name of institution: Clinical Research Institute of Montreal
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Montreal, Quebec, Kanada

  5. Name of institution: Kemijski inštitut
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Ljubljana, Slovenija

  6. Name of institution: Swedish University of Agricultural Sciences
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Umea, Švedska

  7. Name of institution: Institut za medicinska istraživanja i medicinu rada
    Type of institution: State institute
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia
Other information about the project.
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Last update: 09/13/95
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