SVIBOR - Project code: 1-07-194

MINISTRY OF SCIENCE AND TECHNOLOGY

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tel.: +385 1 459 44 44, fax: +385 1 459 44 69
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Project code: 1-07-194

STRUCTURAL INVESTIGATION OF PEPTIDES AND GLYCOPEPTIDES IN SOLUTION

Main researcher: KLAIĆ, BRANIMIR (21025)

Assistants

Type of research: basic
Duration from: 01/01/91. to 12/31/93.

Papers on project (total): 15
Papers on project quoted in Current Contents: 9

Institution name: Institut "Ruđer Bošković", Zagreb (98)
Department/Institute: Department of Organic Chemistry and Biochemistry
Address: Bijenička cesta 54
City: 10000 - Zagreb, Croatia

Communication: Fax: 385 (041)-425-647; Phone: 385 (041)-424-868; Phone: 385 (041)-425-539

Summary: Structural investigation of bioactive glycopeptides including the peptidoglycans and synthetic prepared glucoconjugates of the enkephalins in solution, and structure-biological activity correlation. Study of complexation mentioned compounds with metal cations, to make the structural elucidation easier, and changing the biological activities. In realization of this project modern one- and two-dimensional NMR spectroscopic method will be used.

Keywords: peptidoglycan, peptidoglycan monomer, enkephalin, enkephalin glucoconjugate, one- and two-dimensional NMR spectroscopy, structure in solution, conformation of peptides, conformation of glycopeptides

Research goals: Structure determination in solution of compounds possessing biological activities, including peptidoglycans, which exhibit significant immunomodulating properties in mammals, and synthetic prepared glycosidic esters of the opioidic peptide enkephalin, and correlation of structures and biological activities- SAR (structure activity relationship). Introduction of modern one- and two-dimensional NMR spectroscopic methods, rarely used in our country, and their application on bioactive molecules in solution. The results of this investigations can contribute to development of new active compounds in pharmaceutical industry.

Other information about the project.


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Last update: 02/07/94
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