SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANTIDOTES FOR ORGANOPHOSPHORUS COMPOUNDS
Main researcher
: BINENFELD, ZLATKO (106430) Assistants
DELJAC, ANTE (9241)
DELJAC, VJERA (9252)
RONČEVIĆ-ODŽAK, RENATA (900533)
PRIMOŽIĆ, INES (900819)
Type of research: applied Duration from: 01/01/91. to 12/31/93. Papers on project (total): 12
Papers on project quoted in Current Contents: 8
Institution name: Prirodoslovno-matematički fakultet, Prirodoslovni odjeli, Zagreb (119) Department/Institute: Department of organic chemistry Address: Strossmayerov trg 14 City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)1 432-580
Fax: 385 (0)1 272-066
E-mail: primozic¦olimp.irb.hr
Summary: The aim of this presented research is synthesis of that
organophosphorus compounds which schould have efficacy and universal
antidotal properties in the case of poisoning by organophosphorus copmounds
and also studies of mechanisms of the biological and protection activity of
the antidotes.
Research goals: HI-6 represents the last achievement in the field of
protection from poisoning with organic compounds on its example too, we
proved that the so called cholinesterase thoery is not universal when
protection is concrned. It does not explain the action of different oximes
on cholinesterases inhibited by different organophosphorus compound. This
stays an open field of research for novel oximes bonded to various
heterocyclic and other systems. The purfase of this work is to get new
insights in (the mechanism) of the effects of organophosphorus compounds
as well as thase of antidotal effects of oximes. The final goal is to
find an universal antidote of lowest toxicity and of such chemical
characteristics that it will be possible to use it in preventation as well
as medicinal purposes.
COOPERATION - PROJECTS
Name of project
: 3-01-509 Biološko istraživanje antidota od
trovanja visoko toksičnim OPS. Name of institution: INSTITUT ZA MEDICINSKA ISTRAŽIVANJA I MEDICINU
RADA City: 10000 - Zagreb, Croatia
COOPERATION - INSTITUTIONS
Name of institution
: INSTITUT ZA MEDICINSKA ISTRAŽIVANJA I
MEDICINU RADA Type of institution: University/Faculty Type of cooperation: Joint publishing of scientific papers City: 10000 - Zagreb, Croatia Other information about the project.