SVIBOR - Papers quoted in CC - project code: 1-07-241

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Papers quoted in Current Contents on project 1-07-241

Quoted papers: 8
Other papers: 4
Total: 12

Title: Reactivators of AChE inhibited by organophosphorus compounds. Butenylenic and tetramethylenic heterocyclic oximes.4.

Authors:: Deljac, Vjera (9252); Deljac, Ante (9241); Mesić, Milan (159405); Kilibarda, Vesna; Maksimović, Matej; Binenfeld, Zlatko (106430)

Journal: Acta Pharmaceutica
ISSN: 1330-0075
Volume: 42
Year: 1992
Pages: from 173 to 179
Number of references: 7
Language: engleski
Summary: A series of bis pyridinium and bis imidazolium compounds containing methyl, benzyl, phenyl, 4-methoxyphenyl and 4-fluorophenyl supstituents in position 3 of imidazole ring linked together with tetramethylene and buthylene chain were prepared and caracterised by elemental analysis, IR and NMR spectroscopy. The inhibitory power of the oximes (IC-50) and percentage of reactivation after inhibition by sarin, VX and tabun have been determined on human erithrocyte AChE. IC-50 values varied from 0.0016 to 7.7 mmol l-1. With 2 x 10-5 mol l-1 percentage of reactivation was from 3 to 90.0 5 for sarin, from 3 to 68 % for VX and 1 to 74 % for tabun inhibited AChE. None of compounds reactivates soman inhibited human erythrocyte AChE.
Keywords: organophosphorus compounds, imidazolium oximes, reactivators of AChE, piridinium oximes, inhibitory power

Title: Protectiv effects of mixture of oximes in poisoning by nerve chemical warfare agents.

Authors:: Kovačević, Veljko; Maksimović, Matej; Deljac, Vjera (9252); Binenfeld, Zlatko (106430)

Journal: Acta Pharmaceutica Jugoslavica
ISSN: 1330-0075
Volume: 41
Year: 1991
Pages: from 75 to 78
Number of references: 11
Language: engleski
Summary: The protective effects of oxime HI-6 and Trimedoxime mixture, combined with atropine and diazepam or midazolam, were tested on the rats poisoned by nerve CWAs, as well as the acute toxicity of three mixture of oximes. The higher efficiency of the mixture of these oximes was found in the protection of rats poisoned by tabun, sarin and VX than the of the individual oximes. Moreover, the mixture of oxime HI-6 (25 mg/kg) and Trimedoxime (2.5 mg/kg) in the presence of atropine and diazepam, ensures the higher degree of protection against poisoning by the tabun, sarin and VX than the mixtures of 25 mg/kg HI-6 with 20 mg/kg Pralidoxime or 10 mg/kg Obidoxime. It was also found that acute toxicity of HI-6 and Trimedoxime is similar to that of HI-6 and Obidoxime but much lower than that of HI-6 and Pralidoxime mixture.
Keywords: organophosphorus compounds, reactivators ofAChE, piridinium oximes, acute toxicity, HI-6, Pralidoxime, Obidoxime, Trimedoxime, mixture of oximes

Title: Adamantane derivatives as potential reactivators of acetylcholinesterase inhibited by organophosphorus compounds.

Authors:: Bregovec, Ivo (5356); Maksimović, Matej; Kilibarda, Vesna; Binenfeld, Zlatko (106430)

Journal: Acta Pharmaceutica
ISSN: 1330-0075
Volume: 42
Year: 1992
Pages: from 251 to 253
Number of references: 4
Language: engleski
Summary: All synthesized adamantane compounds were found to bi nonreactive either as inhibitors or as reactivators of humanerythrocyte ACHE inhibited by organophosphorus compounds.
Keywords: organophosphorus compounds, imidazolium oximes, piridinium oximes, adamantane derivatives

Title: Synthesis of reactivators of acethylcholinesterase inhibited by organophosphorus compounds.Imidazole derivatives.3.

Authors:: Mesić, Milan (159405); Deljac, Ante (9241); Deljac, Vjera (9252); Binenfeld, Zlatko (106430); Maksimović, Matej; Kilibarda, Vesna

Journal: Acta Pharmaceutica
ISSN: 1330-0075
Volume: 42
Year: 1992
Pages: from 169 to 172
Number of references: 7
Language: engleski
Summary: The aim of this investigation was to find out to what extent the nature of the p-substituent in N-phenyl imidazolium oximes affects the reactivation of AChE inhibited by organophosphorus compounds. Newly synthesized p-fluorophenyl imidazolium oximes were compared for their activity to the corresponding unsubstituted and p- substituted analoges. The presence of an electron-donating substituent in the para position, as well as of an electron-withdrawing substituent, do not influence either inhibition or reactivation of the AChE inhibited by OP compounds.
Keywords: organophosphorus compounds, imidazolium oximes, reactivators of AChE, IC-50

Title: Reactivators of acetylcholinesterase inhibited by organophosphorus compounds. Imidazole derivatives.2.

Authors:: Mesić, Milan (159405); Deljac, Ante (9241); Deljac, Vjera (9252); Binenfeld, Zlatko (106430); Kilibarda, Vesna; Maksimović, Matej; Kovačević, Veljko

Journal: Acta Pharmaceutica Jugoslavica
ISSN: 1330-0075
Volume: 41
Year: 1991
Pages: from 203 to 210
Number of references: 12
Language: engleski
Summary: A series of mono and bis imidazolium compounds contaning benzyl, phenyl and 4-methoxyphenyl substituents in position 3 of imidazole ring were prepared and characterized by elemental analysis, IR and 1H NMR spectroscopy. Compounds which one imidazole ring was replaced by 2- and 4-hydroxyiminomethylpyridine were also prepared. The inhibitory power of the oximes (IC-50), percentage of reactivation after inhibition by sarin, VX, tabun and soman have been determined for human erythrocyte AChE. IC-50 values vareird from 0,315 to 560 x10-6 mol dm-3. With 20 x 10-6 mol dm-3 percentage of reactivation was 2,87-96,3% for sarin, 2,7-72,8% for VX, 0-44,1% for tabun and 0-10,1% for soman inhibited AChE. Benzylimidazolium oximes given to rats together with atropine provided good protection against VX, tabun and sarin while being little effective in soman poisoning.
Keywords: organophosphorus compounds, imidazolium oximes, reactivators of AChE, piridinium oximes, inhibitory power

Title: Reactivators of acetylcholinesterasa inhibited by organophosphorus compounds. Imidazole derivatives. V.

Authors:: Mesić, Milan (159405); Rončević, Renata; Radić, Božica; Fajdetić, Antun; Binenfeld, Zlatko (106430)

Journal: Acta Pharmaceutica
ISSN: 1330-0075
Volume: 44
Year: 1994
Pages: from 145 to 150
Number of references: 13
Language: engleski
Summary: Four novel (p-methylphenyl(mono-imidazolium, imidazolium-pyridinium and bis-imidazolium)) oximes were prepared. IC-50 values were determined only for BMR-2 and BMR-3 because BMR-1 and BMR-4 provoke <50% inhibition of himan AChE at concetrations <1x10-3 mol/L. BMR-3 was powerful reactivator of soman inhibited human AChE (37%). Only BMR-4, given together with atropine sulfate, provided a good in vivo protection against 1.8 and 2.2xLD-50 soman.
Keywords: imidazole derivatives, acetylcholiesterase reactivation

Title: Synthesis, acute toxicity and protective action of some new oximes in experimental soman poisoning. Imidazole derivatives. VI.

Authors:: Rončević, Renata; Radić, Božica; Fajdetić, Antun; Binenfeld, Zlatko (106430); Mesić, Milan (159405)

Journal: Acta Pharmaceutica
ISSN: 1330-0075
Volume: 44
Year: 1994
Pages: from 151 to 156
Number of references: 15
Language: engleski
Summary: A series of (bis-imidazolium and imidazolium-pyridinium) oximes, linked together with alkane, ether and diether chains, and with methyl, benzil, phenyl and 4-fluorophenyl substituents at position 3 of the imidazole ring, were prepared. Their acute toxicitz (LD50) determined in male mice varied from 0.0008 to 0.124 mmol/kg. Oximes 2C and 2E, given together with atropine sulfate (10 mg/kg), provided a 100% protection against 1.8xLD50 soman and oxime 2B against 2.2xLD50 soman
Keywords: imidazolium oximes, synthesis, toxicity, protection, soman poisoning

Title: Imidazole derivatives. Bis imidazolium and imidazolium-pyridinium oximes: reaction, inhibition and protective action on soman phosphylated human erytrocyte acetylcholinesterase. VII.

Authors:: Radić, Božica; Rončević, Renata; Mesić, Milan (159405); Fajdetić, Antun; Binenfeld, Zlatko (106430)

Journal: Acta Pharmaceutica
ISSN: 1330-0075
Volume: 44
Year: 1994
Pages: from 251 to 255
Number of references: 16
Language: engleski
Summary: The inhibitory power (IC-50), reactivation of soman phosphylated AChE and protection of human erytrocyte AChE against inhibition by soman, were determined by applying bis-imidazolium and two pyridinium-imidazolium oximes containing methyl, benzyl, phenyl and 4-fluorophenyl substituents at position 3 of the imidazole ring. The rings were linked with alkylidene, ether and diether chains. The IC-50 values varied from 2x10-8 to 2x10-4 mol/L.The type of substituent on the imidazole ring and the length of the chain between rings have a significant influence on the IC-50 of these oximes.
Keywords: imidazolium-pyridinium oximes, acetylcholinesterase, soman, inhibition, reactivation


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