SVIBOR - Project code: 1-07-336

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 1-07-336


SYNTHESIS AND APPLICATION OF ADAMANTANE AND RELATED COMPOUNDS


Main researcher: ŠKARE, DANKO (94313)


Assistants
Type of research: basic
Duration from: 11/15/94.
Papers on project (total): 6
Papers on project quoted in Current Contents: 1
Institution name: Institut "Ruđer Bošković", Zagreb (98)
Department/Institute: Organic Chemistry and Biochemistry
Address: Bijenička c. 54
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (01) 4561-141
Fax: 385 (01) 425-647
Summary: The project comprises several segments: a) syntheses of new adamantyl phencyclidines and their characterization by instrumental methods b) biological testing of these compounds using cultural cells and mice in order to get data about toxicity, anesthetic and analgetic properties c) Investigation of new polynitroadamantane compounds determining their explosibility properties and efforts for their synthesis on a laboratory scale. d) Syntheses of new hexacyclic cage systems with strained cyclopropane ring in their structure in order to test their chemical and physical properties. Application of combined spectroscopic and theoretical methods to elucidate the structures of new compounds. e) Structure-activity and/or structure-reactivity relationships of new compounds by QSAR and QSPR methodology, respectively.

Keywords: Adamantane, phencyclidine, adamantyl derivative, biological activity, polynitroadamantanes, explosibility, additive methods, triaxanoadamantane, triaxanonoradamantane, hexacyclic cage compounds, cyclopropane, synthesis and properties, QSAR and QSPR methodology.

Research goals: Syntheses of new adamantyl derivatives of phencyclidine including thienyl and other aromatic moieties instead of phenyl, and their testing on cells and lower animals presumably would show better analgetic and anesthetic properties than phencyclidine itself, with lower toxicity. For these compounds it is also expected to be efficient radioprotectors. Calculation of explosibility parameters for polynitroadamantane compounds would allow the proper choice of their synthesis on the laboratory scale and experimental testing of their properties. Such compounds could posses the better explosion characteristics than HMX. Synthesis of triaxanoadamantane and triaxanonoradamantane, hexacyclic cage compounds with cyclopropane in their structure would allow experimental investigation of structure-reactivity relations in order to propose organic reactions.

COOPERATION - PROJECTS


  1. Name of project: 1-07-187 Sinteze i kemija adamantana i srodnih policikličkih molekula
    Name of institution: Institut "Ruđer Bošković"
    City: 10000 - Zagreb, Croatia
Other information about the project.
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