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Summary: Since the multistep process of development of the gut is
accompanied by tissue and cell to cell interactions and pressumably by
trophic action of peptide hormons, the aim of this study was first to
follow the frequency and distribution pattern of neuroendocrine and
particularely gastrin cells in human antrum and bovine abomasum during
ontogenesis. For the identification of common neuroendocrine cells in both
species neuron-specific enolase and chromogranine A served as
immunohistochemical markers. During the investigation of differentiation
process of the human antrum and bovine abomasum, two lectins (DBA and UEA
I) proved to be the best markers of stomach epithelium and the glands.
Research goals: The aim of this study was to follow the frequency
and the distribution of neuroendocrine cells, particularely gastrin and
somatostatin cells in the gastro-entero-pancreatic system of mammals during
ontogeny by use of immunohistochemical methods and changes in
glycoconjugates of cell membranes, epithelial cells and cytoplasmatic
compartments of the stomach glands.This research showed that correlation
between neuroendocrine cells and regulatory peptides, which they produced,
and differentiation and proliferation process of the stomach glands egsist.
COOPERATION - INSTITUTIONS
Name of institution
: Klinička bolnica "Sestre milosrdnice",
Klinički zavod za patologiju "Prof. dr. Ljudevit Jurak" Type of institution: International organization City: 10000 - Zagreb, Croatia Other information about the project.