SVIBOR - Project code: 1-08-295

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 1-08-295


GLYCOCONJUGATES AND REGULATORY PEPTIDES IN GASTRO-ENTERO-PANCREATIC SYSTEM DURING THE DEVELOPMENT


Main researcher: RODE, BOJAN (41266)



Assistants
Type of research: basic
Duration from: 06/12/91. to 12/31/93.

Papers on project (total): 3
Papers on project quoted in Current Contents: 1
Institution name: Prirodoslovno-matematički fakultet, Prirodoslovni odjeli, Zagreb (119)
Department/Institute: Department of Zoology
Address: Rooseveltov trg 6
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)41 44-26-04/29

Summary: Since the multistep process of development of the gut is accompanied by tissue and cell to cell interactions and pressumably by trophic action of peptide hormons, the aim of this study was first to follow the frequency and distribution pattern of neuroendocrine and particularely gastrin cells in human antrum and bovine abomasum during ontogenesis. For the identification of common neuroendocrine cells in both species neuron-specific enolase and chromogranine A served as immunohistochemical markers. During the investigation of differentiation process of the human antrum and bovine abomasum, two lectins (DBA and UEA I) proved to be the best markers of stomach epithelium and the glands.

Keywords: Human antrum, bovine abomasum, development, neuroendocrine cells, gastrin, somatostatin, lectins, immunohistochemistry, stereology

Research goals: The aim of this study was to follow the frequency and the distribution of neuroendocrine cells, particularely gastrin and somatostatin cells in the gastro-entero-pancreatic system of mammals during ontogeny by use of immunohistochemical methods and changes in glycoconjugates of cell membranes, epithelial cells and cytoplasmatic compartments of the stomach glands.This research showed that correlation between neuroendocrine cells and regulatory peptides, which they produced, and differentiation and proliferation process of the stomach glands egsist.


COOPERATION - INSTITUTIONS


  1. Name of institution: Klinička bolnica "Sestre milosrdnice", Klinički zavod za patologiju "Prof. dr. Ljudevit Jurak"
    Type of institution: International organization
    City: 10000 - Zagreb, Croatia

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Last update: 02/24/94
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