SVIBOR - Project code: 1-08-329

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

SVIBOR - Collecting Data on Projects in Croatia

Project code: 1-08-329


TARGET SITES IN HUMAN GENOME CONNECTED WITH THE PROCESS OF CANCEROGENESES


Main researcher: GARAJ-VRHOVAC, VERA (105181)


Assistants
Type of research: applied
Duration from: 06/01/93. to 12/31/94.
Papers on project (total): 6
Papers on project quoted in Current Contents: 1
Institution name: Institut za medicinska istraživanja i medicinu rada, Zagreb (22)
Department/Institute: Laboratory for mutagenesis
Address: Ksaverska c. 2
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)41 674 572
Phone: 385 (0)41 434 188
Fax: 385 (0)41 274 572
Fax: 385 (0)41 674 572
Summary: In the past six month as the project started methodologicalpreparations for experimental work have been done and data ofbackground values for cytogenetic study have been collected.

Keywords: molecular epidemiology of carcinomas, target sites in human genome,ionizing radiation,non-ionizing radiation,vinyl chloride monomer, chromosome abberation assay, sister chromatid exchange, micronucleus essay, mitotic index, G-banding

Research goals: The aim of this research which will be perfomed in experimental conditions simulating those of the working environment is to confirm that mutagenic agents damage human chromosome in a non-random pattern.Target sites on human and animal chromosomes will be determined for three environmental mutagens:ionizing radiation,non-ionizing radiation and vinyl chloride monomer.Knowledge of carcinomas related specifically to work places with exposure to those mutagens and data on carcinoma specific changes in chromosomes should contribute to the development of molecular epidemiology of some carcinomas.In that way medical care of a population occupationally exposed to environmental mutagens could achive a new quality as medical prevention based on our results and results of similar studies could intensify a specific group of medical examinations.

COOPERATION - PROJECTS


  1. Name of project: COST 244 Biomedical effects of electromagnetic fields
    Name of institution: Elektrotehnički fakultet
    City: 10000 - Zagreb, Croatia

COOPERATION - INSTITUTIONS


  1. Name of institution: Zavod za zrakoplovnu medicinu
    Type of institution: International organization
    Type of cooperation: Systematic exchange of information
    City: 10000 - Zagreb, Croatia

  2. Name of institution: National laboratory university of Californija
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of information
    City: Livermore, SAD

  3. Name of institution: S.C.K./V.I.T.O
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of information
    City: B-2400 - Mol, Belgija

  4. Name of institution: KB "Merkur" Zavod za radiologiju
    Type of institution: International organization
    Type of cooperation: Joint project
    City: 10000 - Zagreb, Croatia

  5. Name of institution: Laboratorij za citogenetiku KBC Rebro
    Type of institution: International organization
    Type of cooperation: Joint project
    City: 10000 - Zagreb, Croatia

  6. Name of institution: Medical Research Council, University of Sussex
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of information
    City: Brighton, Velika Britanija
Other information about the project.
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Last update: 09/27/95
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