SVIBOR - Project code: 3-01-038

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-038


BIOMECHANICS OF MUSCULO-SKELETAL SYSTEM UNDER VARIOUS CONDITIONS


Main researcher: NIKOLIĆ, VASILIJE (33414)


Assistants
Type of research: basic
Duration from: 01/01/91. to 12/31/93.
Papers on project (total): 94
Papers on project quoted in Current Contents: 22
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of Anatomy, School of Medicine, University of Zagreb
Address: Šalata 11, Zagreb
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (0)4566953
Phone: 385 (0)4566925
Fax: 385 (0)271195
E-mail: nikolicv mamef.mef.hr
Summary: The study comprises a complex analysis of the structure and biomehcanical properties of all parts of the locomotor system aimed at the collection of quantitative, morphological, anthropometric and structural parameters representing data base for working out of mathematical models for biomechanical processes in osteoporosis, fractures, surgical treatment of fractures and skeletal deformities. The bone structure will be analysed by use of densitometric methods and computed tomography. Mechanical properties and modulus of elasticity dependent on bone density will then be determined on anatomic preparations and bone samples. In order to obtain data necessary for determination of muscular force and momentums of a muscle acting upon a bone or a particular joint, or in fractures upon a particular fragment in vivo, the muscular structure will be treated on anatomic preparations, a special method being applied. Incoming data will be obtained when analysing the geometry and position of the muscle by use of computed tomography. The research /analysis/ will be done on two samples. The first sample consists of several anatomic preparations on which non-invasive methods /CT, densitometry, ultrasound/ will be applied at first and destructive methods /dissection, measurements and sample analysis/ afterwards in order to obtain only thus obtained data. The inspection of the accuracy of non-invasive diagnostic methods and of the correlation of these findings with mechanical properties will be enabled by the comparison of all collected data. The second sample consists of a number of injured with different types of bone fracture on which the above methods will be applied. The third sample is a clinical model for regressive bone changes - renal osteodystrophy (ROD). Biochemical and histomorphological parameters relevant for biomechanics were done on an experimental animal model (rats).

Keywords: Biomechanics, Bones, Bone fractures, Fracture healing, Osteoporosis, Densitometry, Computed tomography, Muscles, Joints, Renal osteodystrophz - ROD.

Research goals: The research on mechanical properties of the supporting tissue, especially of bones, determination of the relation between the modulus of elasticity and density of the tissue, testing of callus tissue strength. To obtain data about the state and geometry of the locomotor system in regressive changes /osteoporosis, joint arthrosis/, in progressive processes /growth and functional adaption/, then in regeneration of bone fractures. To obtain topographic and age difference in dynamics of callus consoldation and mineralization related to biomechanical occurrences in fractured regions. To develop a method in order to obtain a more accurate analysis of the structural geometry of bones in vivo. To obtain data about force structural bone geometry interrelations under bone fracture menacing /osteoporosis, bone tumours/ or bone fracture in the course of healing. To obtain data about pressure distribution analysis within joints, to improve methodology and obtain results for various joints under various force transmission conditions. Biodynamic analysis of the locomotor system. Mathematical modelling of functional and geometric interdependence of bony, muscular and collagenous elements in movements. Mathematical modelling of bone regeneration dynamics. To develop data base as incoming parameters for generation of the model of skeletal finite elementsmethods (FEM) under various conditions. The final objective of the research is a better comprehension of locomotor system biomechanics in various states in orthopaedics, traumatology, rheumatology and physical medicine. It is also a data base and methodology for mathematical modelling serving as a basis for individual designing of surgical procedures /or other kinds of therapy/ in fractures, tumours or orthopaedic bone deformities, or in endoprosthetic treatments of joints. All this presents an introduction of objective parameters into diagnostics of the locomotor system along with quantitative numerical parameters; exclusion of any subjectivity in the diganostics of changes and damages to the locomtor system /present state/; optimalization of therapy. Diseases of the locomotorsystem-trauma, deformities, degenerative diseases, osteoporosis and renal osteodistrophy with its side-effects, etc. play an important /essential/ role in pathology of the population.

COOPERATION - PROJECTS



COOPERATION - INSTITUTIONS


  1. Name of institution: Kirurška klinika,
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Klinika za traumatologiju
    Type of institution: University/Faculty
    Type of cooperation: Joint project
    City: 10000 - Zagreb, Croatia

  3. Name of institution: The University of Utah,School of Medicine, Division of Radiobiology
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: Salt Lake City, Utah, USA

  4. Name of institution: Katharinenhospital, Univ. Tubingen, Abt. fur Unfall-chirurgie
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of experts
    City: Stuttgart, Deutschland

  5. Name of institution: Rudarsko-geološko-naftni fakultet
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia

  6. Name of institution: Elektrotehnički fakultet Sveučilišta u Zagrebu
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of information
    City: 10000 - Zagreb, Croatia

  7. Name of institution: Građevinski fakultet
    Type of institution: University/Faculty
    Type of cooperation: Joint publishing of scientific papers
    City: 10000 - Zagreb, Croatia
Other information about the project.
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