SVIBOR - Project code: 3-01-114


Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69


SVIBOR - Collecting Data on Projects in Croatia

Project code: 3-01-114


Main researcher: MILIČIĆ, DUŠKO (31471)

Type of research: developmental
Duration from: 01/01/91. to 12/31/94.

Papers on project (total): 25
Papers on project quoted in Current Contents: 3
Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of gynaecologic surgery and urology, Clinic for women disease and obstetrics, Medical faculty in Zagreb
Address: Petrova 13
City: 10000 - Zagreb, Croatia
Phone: 385 (0)1 444 022
Fax: 385 (0)1 444 279
Phone: 385 (0)1 444 022

Summary: Urinary icontinence is more frequent in women than in men. There are different types of urinary incontinence which can be the resultof multiple interrelated factors such as neurologic disorders, neuromuscular dysfunction or inflammatory disease. But the most frequent cause of urinary incontinence is weak or impaired anatomic support of the urogenital system with considerable contribution of disorded local innervation(stress or static incontinence). The incidence of stress urinary incontinence in women over 45 years is 20-30%. The disease is serious and its consequences could be difficult. Due to anatomic and topographic changes which caused descending of the bladder base and represent a reservoir for bacterial multiplication and their ascension leads to progressive pyelonephritis. The result of long timetherapy of uroinfections according to antibiogram without elimination of residual urine is developing of resistant bacteria and progressive pyelonephritis which leads to dialysis and death.Disorders of the anatomic support of urogenital system caused mostly by birth which role is important in etiology of stress urinary incontinence. Negative factors increased in war conditions because of inadequate delivery and postpartal care. We expect higher incidence of morbidity. In project, our research is based on insufficiently known interrupted innervation of the lower urinary tract disorders. The dillema is how to improve conditions of urethral neurologic disorders, when operation is needed. By electronic urodynamic differentiation and electroneuromyography of voiding dysfunctions wecould be closer to optimal therapy in every case.

Keywords: Neurourology, urodynamics, female stress incontinence , urge incontinence, mixed incontinence, electroneuromyography, innervation of lower urinary tract,operative methods, conservative treatment

Research goals: 1. Investigate insuffitiently known and unknown factors offunctional disorders of micturition in women. 2. Optimal differentiation of relevant symptoms with moderndiagnostics and objectivisation for selected therapy. 3. Selection of surgical procedures for treatment which less thanothers disturbes innervation of functional unit and causes theleast damage for patient's sexually and work life. 4. Systematization of methods for conservative therapy accordingto the precise verification of parametars to which it is applied. 5. How to completely avoid iatrogenic infections of thelower urinary tract. 6. Summarily coefficient of the disease necessary for actualevaluation of the condition.It would be the sign-post to approachfor complexity of therapy. 7. Explanation of patophysiology in local innervation of theurethra and urinary bladder in stress, urge and mixed urinaryincontinence in women. 8. Explanation of disturbances on the leverl of alpha and betareceptors of the urethra and urinary bladder. 9. Finding out surgical methods for treatment of stress urinaryincontinence which do not intensify neurologic disorders. 10.Systematization of drugs and procedures for conservativetherapy according to precise established etiology of voidingdisorders. 11. Creating a standard vaginotonographic curve among normal andimpaired pelvic floor in the women of the same age.


  1. Name of institution: Klinika za urologiju Medicinskog fakulteta, Rebro
    Type of institution: University/Faculty
    City: 10000 - Zagreb, Croatia

  2. Name of institution: Zavod za urologiju bolnice "Sveti duh"
    Type of institution: University/Faculty
    City: 10000 - Zagreb, Croatia

  3. Name of institution: Klinika za neurologiju Medicinskog fakulteta, Rebro
    Type of institution: University/Faculty
    City: 10000 - Zagreb, Croatia

  4. Name of institution: Ginekološka klinika u Ljubljani
    Type of institution: University/Faculty
    City: Ljubljana, Slovenija

  5. Name of institution: Institute Karolinska
    Type of institution: University/Faculty
    City: Stockholm, Švedska

  6. Name of institution: Orange University of California
    Type of institution: University/Faculty
    City: Orange, SAD

  7. Name of institution: Memorial center for women disease
    Type of institution: University/Faculty
    City: Long Beach, CA, SAD

  8. Name of institution: Scientific unit University of Buenos Aires
    Type of institution: University/Faculty
    City: Buenos Aires, Argentina

  9. Name of institution: Frauenklinik
    Type of institution: University/Faculty
    Type of cooperation: Systematic exchange of experts
    City: Graz, Austrija

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Last update: 10/18/95