SVIBOR - Project code: 3-01-136

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

SVIBOR

SVIBOR - Collecting Data on Projects in Croatia


Project code: 3-01-136


DETERMINISTIC AND STOCHASTIC MODELS IN BIOMEDICINE


Main researcher: JOVANOVIĆ, VELJKO (18926)



Assistants
Type of research: basic
Duration from: 01/01/91. to 06/01/94.

Papers on project (total): 34
Papers on project quoted in Current Contents: 11
Institution name: Institut za medicinska istraživanja i medicinu rada, Zagreb (22)
Communication

Summary: The purpose of the project is to define common characteristics of mathematical modelling in biomedicine, and to construct a cybernetic (feedback) controlled multicompartmental model for simulation of stochastic and deterministic processes in biosystems. Construction of specific models and their application were also investigated in different fields of biomedicine: 1. dynamics of infectious diseases, 2. lung ventilatory functions and bronchial reactivity, 3. in vivo transfer through biological barriers and studying migration in connection with population structure. The investigated models would find application in sanitary politics of Republic Croatia

Keywords: Key words: deterministic-stochastic; models-..(pharmaco) kinetic, ..factor, ..migrational, ..of chronic and infectious diseases, epidemiological; (de)convolution methods, Monte Carlo simulation, immunological status

Research goals: Mathematical modelling has a specific role in biomedicine giving theoretical ground for organization of investigation in this field. At the same time models present a basis for understanding biomedical causality. Recently applied models in different fields of biomedicine have been characterized by some aspects of cybernetic feed- back control. The models serve to estimate the state of given substructure and to determine the dynamics of interaction.For this purpose compartmental analysis is usually applied through iterative computer program. The application of convolution integral is a promising extension in this type of analysis. The proposed investigations have a two-fold purpose: A) to give an outline of the scope and common characteristics of modelling in biomedicine and B) construction of specific models and their application. Common characteristics of the models will be analysed through the construction and application of both deterministic and stochastic models. Deterministic models affects the conception of stochastic models applied in biomedicine. This fact is specially relevant to the current epidemiological investigations, results of which are deduced from multivariate statistical analyses. We believe that such models will make important contribution to the better understanding of causality of diseases and to preventing their propagation. The existing software for simulation, modelling and statistical analyses will be complemented by the software developed specifically by members of the staff.


COOPERATION - PROJECTS



Other information about the project.
MZT Croatian language SVIBOR Alphabetic list Sorted on project code Sorted on institutions Search help
Ministry of
Science and
Technology
Croatian
language
Svibor
homepage
Alphabetic
list
Sorted on
project code
Sorted on
institutions
Search Help

Last update: 10/10/95
Information: svibor@znanost.hr