SVIBOR - Project code: 3-01-161

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-01-161


Detection of alergic diseases by establishing IgE in neonates' blood


Main researcher: VEKARIĆ, SEMIDA (138876)


Assistants
Type of research: applied
Duration from: 01/01/91. to 12/15/95.
Papers on project (total): 13
Papers on project quoted in Current Contents: 5
Institution name: Medicinski fakultet, Rijeka (62)
Department/Institute: Department of Paediatrics "Kantrida", Hospital Rijeka
Address: Istarska 43
City: 51000 - Rijeka, Croatia
Communication
Phone: 385 (0)51-614-416
Phone: 385 (0)51-261-611
Summary: Today, more and more, with increasing frequency, allergicdiseases afflict children's health even at their early age and ascronic diseases they affect 15-20% of the children population. Since the correlation between the increased IgE concentrationsand atopy is very good, we consider the creening of IgE fromneonates' cord venous blood, at birth, the most important riskfactor according to which it is possible to predict appearance ofallergy in their cearly childhood. The studies carried out in Swedenn, Kjellman and all, reveal that80.2% of the children whose IgE were increased at birth, get someform of allergic disease before they reach six. Only 3.4% of thechildren with increased IgE concentrations at neonatal age do notget any form of allercig disease at their older age. The samegroup of authors also state that by observing allergy appearancein children, it has been found out that 93.7% of the sick childrehad increased IgE concentrations at birth. Therefore, we think that it colud be a successful preventiveprogramme for early detection of allergic diseases in childrenand at the same it has its economical justification since itenables the society to save up. Namely, the total IgE screeningexpenses in neonatal period are considerably lower than theexpenses needed for medical treatment of the children whochronically suffer from allergic diseases (for example: bronchialasthma atc.).

Keywords: atopy, cord serum, IgE, newborn, prediction

Research goals: Our research of IgE concentrations in nweborns is aiming at: 1. predictiong of allergic disorders as early as possible, namely, carrying out selection of future allergy - sufferers. There is a certaion knowledge which helps us to prove that IgE taken from the newborns' code vein can serve in predicting of allergic disease development: - fetus is capable to synthesize IgE quite independently already in the 11th weed of its intrauterinal life; - mother's IgE do not pass through placenta; - there is a very good clinical correlation between increased IgE concentration and atopy. 2. Timely noticing of causative factors and carrying out of measures by which appearance of clinical disorders could be postponed; 3. Duly and timely medical treatment of the ocurred difficulties. 4. Enabling in this way certain economical savings and lower expenses which society has for medical treatment of children who suffer from cronic allegic diseases.

OTHER ACHIEVEMENTS


  1. Name: Polinoza i specifična hiposenzibilizacija u djece (magistarski rad)
    Type of achievement: Studies of conduct
    Authors: Muhvić-Ostojić Đurđica, (mentor: Vekarić Semida)
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