Type of research: applied Duration from: 01/01/90. to 12/31/94. Papers on project (total): 13
Institution name: Bolnica "Sestre milosrdnice", Zagreb (134) Department/Institute: Department for Clinical Psychiatry Universitry Department for Psychiatry, Alcoholism and other Dependencies Address: Vinogradska cesta 29 City: 10000 - Zagreb, Croatia
Phone: 385 (0)1- 275 725
Phone: 385 (0)1- 174 666 /345
Fax: 385 (0)1- 172 453
Summary: The aim of this investigation was to explore biochemical
patterns present in the endogenes psychoses. We compared 42 patients
diagnosed as maior depression (MD) with 54 schizophrenic patients (SCH).
The complete clinical and laboratory investigations were performed with
special regard to the biochemical analisys of neurotransmitters and its
metabolites as well as on psychological tests. The results have shown that
the blood level of serotonin, prolactin, adrenalin, noradrenalin and 24
hours concetration of 5-HIAA in urine are rather low in the group MD,
especially in those patients with strong suicidal tendencies. Opposite
results have been observed in the group SCH which are simular to the
finding observed during the manic phase of bipolar affective disorder.(
LDH< 0.01, GamaGT <0.001, Serotonin<0.001 , 5-HIAA in 24h urine <0.05 ).
These results correlate with psychis states measured by Overall's brief
psychiatric rating scale (BPRS), Hamilton's depression scale (HAMD) and
Beck questionary (BECK). (BPRS :NS, HAMD:<0.001, BECK:<0.001,). It is very
important for the therapeutic treatment of these disorders. This research
was performed at the Psychiatric Department of Clinical Hospital "Sestre
Milosrdnice" in Zagreb.
Keywords: Biochemical Disturbances , Psychotic States , Major Depression , Schizophrenia , Symptomatic Psychoses
COOPERATION - INSTITUTIONS
Name of institution
: Zavod za endokrinologiju, dijabetes u
bolesti metabolizma, Klinička bolnica "Sestre Milosrdnice" , Zagreb,
Vinogradska cesta 29 Type of institution: International organization Type of cooperation: Joint publishing of scientific papers City: 10000 - Zagreb, Croatia Other information about the project.