SVIBOR - Project code: 3-01-326

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
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Project code: 3-01-326

EFFECTS OF DRUGS AND DISEASES ON CHOLINESTERASE ACTIVITY

Main researcher: KUNEC-VAJIĆ, ESTERA (24653)

Assistants

BRADAMANTE, VLASTA (5110)
POPOVIĆ, LJILJANA (113536)

Type of research: basic
Duration from: 01/01/91. to 12/15/95.

Papers on project (total): 19
Papers on project quoted in Current Contents: 2

Institution name: Medicinski fakultet, Zagreb (108)
Department/Institute: Department of pharmacology
Address: Šalata 11, pp 916
City: 10000 - Zagreb, Croatia

Communication: Phone: 385 (0)1 4566-927; Fax: 385 (0)1 424-001

Summary: The role of ChE in the metabolism of lipids and lipoproteins has been investigated. ChE activity in plasma, liver and adipose tissue has been determined in rats with pathologically disturbed lipid metabolism (diabetes, fasting, hyper- and hypothyreosis) as well as after the administration of drugs which influence plasma levels of lipids and lipoproteins (hypolipidemic agents, acetylsalicylic acid, beta-blockers, estrogens, progesterone). Plasma ChE activities in patients with hyper- and hypothyreosis were also measured. According to our results liver ChE activity correlates better with the level of VLDL production than with the level of peroxisomal beta-oxidation. The alterations of adipose tissue ChE activity were independent of the alterations of liver ChE activity. Moreover, as ChE activity in liver and adipose tissue were differently affected by age and sex, it has been proposed that adipose tissue ChE did not originate from the liver. It seems that adipose tissue ChE is also involved in lipid metabolism since it has been noticed that adipose tissue ChE activity is always increased in the states with enhanced triglyceride deposition in adipose tissue.

Keywords: cholinesterase, lipids, lipoproteins, sex difference, diabetes, fasting, hyperthyreosis, hypothyreosis, hypolipidemic agents, acetylsalicylic acid, beta-blockers, estrogens, progesterone

Research goals: The primary aim of our studies was to gain further informations concerning the physiological role of ChE in the body. The determination of ChE activity in states with disturbed lipid and lipoprotein metabolism could shed light on the involvement of ChE in the metabolism of lipids and lipoproteins. Investigating the effects of drugs on ChE activity (various hypolipidemic agents, acetylsalicylic acid, oxprenolol, levothyroxin, propylthiouracil, estradiol, progesterone) additional data on the mechanism of action or side effects of these drugs could be obtained.

Other information about the project.


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