Summary: Effects of some curative substances (azitromycine,
peptidoglycane monomere), anestetic (menocain), heavy methal (cadmium,
lead, mercury), pesticide (Fastac), herbicide (atrazine), food aditives
(dicalcium phosphate, tricalcium phosphate) and radiation effects on the
biolocical characteristics of test organisms (culture of monkey kidney
epithelial cells, hen embryos, mouse embryos and fetuses, fish fingerlings,
fishes, crustacea - Palaemon squilla, piglets and dogs) were studied. As
well, the histomorphological and histochemical characteristics of notochord
of bovine embryo and glycogen body of turkey embrio were studied. It was
found that azitromycine had strong side effect, but peptidoglycane monomere
almost were biologicaly inactive. If given in recommended doses, the
anestetic Menocain doesn't produce any pathological or hemathological
changes, it only produces nonsignificant changes in acido-basical balance
and the increasing of partial pressure of CO2. Different quantities of
cadmium are acumulated in various fish organs. As well, it produces changes
in some values of hemathological parametars. Studied pesticide demonstrate
significant toxicity for the crustacea. Tricalcium phosphate and dicalcium
phosphate are of the same biological values in the swine feed. The bone
fracture doesn't increase the effect of sublethal gamma-radiation.
Histomorphological and histochemical characteristics of bovine notochord
and turkey glycogen body are similar to those of the other animal species.
No embryonal abnormalities (i.e. no teratogenic effect) are likely to be
produced by doses between 2.23 mg and 142.86 mg atrazine (herbicide) per 1
kg of eggs injected to yolk sack at the 5th day of incubation of the chick
embryos. But the higher studied doses of atrazine produced higher
frequencies of embryonal deaths at mouse embryos too, retardation of yolk
sac involution and hypoplasia of splenic corpuscles at hen embryos.
Keywords: bioactive agents, animal development, side effect of drugs, effect on animal development.
Research goals: The goals of these studies are to find out effects
of different bioactive agents (xenobiotics) on experimental animals and
their development. These agents include some drugs, pesticides,
herbicides, feed aditives and environmental pollutants. The use of those
agents could have adverse effects on the individuals, the human
populations and on the whole environment. Their effects could be very
dangerous, toxic, mutagenc and teratogenic. Because of that, we should
know all of their effects, to be able to prevent their eventual harmful
effects. The results of these studies will show us their effects on live
organisms and on the environment. That will enable us to handle those
agents with better care and without any risks. Other information about the project.