SVIBOR - Project code: 3-03-288


Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69


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Project code: 3-03-288

Bioactive agents and development of laboratory animals.

Main researcher: GOMERČIĆ, HRVOJE (13875)

Type of research: basic
Duration from: 01/01/95.

Papers on project (total): 35
Papers on project quoted in Current Contents: 1
Institution name: Veterinarski fakultet, Zagreb (53)
Department/Institute: Department of Anatomy, Histology and Embryology
Address: 10000 ZAGREB, Heinzelova 55, CRAOTIA
City: 10000 - Zagreb, Croatia
Phone: 385 (1) 23 90 250
Fax: 385 (1) 214 697

Summary: Effects of some curative substances (azitromycine, peptidoglycane monomere), anestetic (menocain), heavy methal (cadmium, lead, mercury), pesticide (Fastac), herbicide (atrazine), food aditives (dicalcium phosphate, tricalcium phosphate) and radiation effects on the biolocical characteristics of test organisms (culture of monkey kidney epithelial cells, hen embryos, mouse embryos and fetuses, fish fingerlings, fishes, crustacea - Palaemon squilla, piglets and dogs) were studied. As well, the histomorphological and histochemical characteristics of notochord of bovine embryo and glycogen body of turkey embrio were studied. It was found that azitromycine had strong side effect, but peptidoglycane monomere almost were biologicaly inactive. If given in recommended doses, the anestetic Menocain doesn't produce any pathological or hemathological changes, it only produces nonsignificant changes in acido-basical balance and the increasing of partial pressure of CO2. Different quantities of cadmium are acumulated in various fish organs. As well, it produces changes in some values of hemathological parametars. Studied pesticide demonstrate significant toxicity for the crustacea. Tricalcium phosphate and dicalcium phosphate are of the same biological values in the swine feed. The bone fracture doesn't increase the effect of sublethal gamma-radiation. Histomorphological and histochemical characteristics of bovine notochord and turkey glycogen body are similar to those of the other animal species. No embryonal abnormalities (i.e. no teratogenic effect) are likely to be produced by doses between 2.23 mg and 142.86 mg atrazine (herbicide) per 1 kg of eggs injected to yolk sack at the 5th day of incubation of the chick embryos. But the higher studied doses of atrazine produced higher frequencies of embryonal deaths at mouse embryos too, retardation of yolk sac involution and hypoplasia of splenic corpuscles at hen embryos.

Keywords: bioactive agents, animal development, side effect of drugs, effect on animal development.

Research goals: The goals of these studies are to find out effects of different bioactive agents (xenobiotics) on experimental animals and their development. These agents include some drugs, pesticides, herbicides, feed aditives and environmental pollutants. The use of those agents could have adverse effects on the individuals, the human populations and on the whole environment. Their effects could be very dangerous, toxic, mutagenc and teratogenic. Because of that, we should know all of their effects, to be able to prevent their eventual harmful effects. The results of these studies will show us their effects on live organisms and on the environment. That will enable us to handle those agents with better care and without any risks.

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Last update: 10/15/95