SVIBOR - Project code: 3-04-318

MINISTRY OF SCIENCE AND TECHNOLOGY

Strossmayerov trg 4, HR - 10000 ZAGREB
tel.: +385 1 459 44 44, fax: +385 1 459 44 69
E-mail: ured@znanost.hr

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Project code: 3-04-318


Research on active compounds in medicinal plants of Croatia


Main researcher: KALOĐERA, ZDENKA (19931)


Assistants
Type of research: applied
Duration from: 01/01/91. to 12/31/95.
Papers on project (total): 43
Papers on project quoted in Current Contents: 11
Institution name: Farmaceutsko-biokemijski fakultet, Zagreb (6)
Department/Institute: Department of Pharmacognosy
Address: Ante Kovačića 1
City: 10000 - Zagreb, Croatia
Communication
Phone: 385 (01)44 61 35
Fax: 385 (01)44 51 17
Summary: Various plant species of the Croatian flora yet unresearched in terms of their chemism and pharmacological effect have been examined. Micromeria thymifolia, Satureja montana, Satureja subspicata, Helychrisum italicum, Teucrium arduini and Teucrium flavum have been tested for the quantity, composition and biological effect of essential oil. As far as active compounds are concerned, triterpene, saponins and flavonoids have been isolated. Chromatography and mass spectroscopy have been applied to characterize the isolated compounds. Alkaloids, whose cytostatic effect was confirmed by biological tests, have been isolated. Chemical testing of Caucalis platycarpos indicated the presence of sitosterol, scopoletin, tannin, lignin and flavonoids. Ononis natrix, Tanacetum parthenium, Solidago gigantea, Solidago canadensis, Solidago virgaurea have been examined for their diuretic effect. Antimicrobial activity (gram negative,gram positive bacteria and fungi) has been tested in Berberis croatica, Eleuterococcus senticosus, Glycine hispida, Micromeria thymifolia. Special emphasis has been given to the effect on dermatophytes. Several extracts of Pelargonium radula were tested on hypoglicaemic effect. The content and composition of the essential oil from Micromeria thymifolia and Helichrysum italicum were determined. Comparative phytochemistry investigation of genus Symphytum showed a presence of saponins, flavonoids and triterpenoids. The triterpenic acids were isolated from Micromeria thymifolia.

Keywords: Doronicum austriacum, Micromeria thymifolia, Teucrium arduini, Teucrium flavum, Satureja montana, Satureja subspicata, Satureja montana subsp.montana, Eleuterococcus senticosus, Glycine hispida, Caucalis platycarpos, Solidago canadensis, Solidago virgaurea, Solidago gigantea, cytostatic effect, alkaloids, antibacterial activity, antifungal activity, flavonoids, essential oil, diuretic effect, Lamium species, Helichrysum italicum, Symphytum officinale, Symphytum tuberosum, Tanacetum parthenium, hypoglicaemic effect, triterpenic acids.

Research goals: The flora of Croatia is characterized by great variety and numberof species. Many species have not yet been researched in terms oftheir chemism and pharmacological effect. Continuous search fornew biologically active compounds is necessary, which includesexamination of unexplored medicinal plants Croatia abounds in.Finding new active principles in natural resources is certainly asignificant contribution to pharmacy, particulary at a time whenphytoterapeutics are gaining more and more importance in medicaltreatment. Alkaloid drugs such as Doronicum austriacum and Berberiscroatica belong to the group of yet unexplored Croatian plants.Alkaloids with proved cytostatic effect have been isolated fromDoronicum austriacum. New areas of biological activity(microbiological) have been found for the alkaloid in Berberiscroatica. Antimicrobial activity has also been tested inEleuterococcus senticosus and Glycine hispida. The content , composition and microbiological activity of Micromeria thymifolia and Helichrysum italicum were performed. The plants showed a wide activity on bacteria, fungi and dermatophytes. The phytochemical investigation and biological activity of Pelargonium radula, Tanacetum parthenium and Symphytum officinale were perfprmed.

COOPERATION - PROJECTS


  1. Name of project: 3-01-274 Mikromicete i utjecaj njihovih toksina na zdravlje ljudi i Đivotinja
    Name of institution: Farmaceutsko-biokemijski fakultet
    City: 10000 - Zagreb, Croatia

  2. Name of project: 3-01-273 Mehanizmi regulacije transporta u bubregu
    Name of institution: Farmaceutsko-biokemijski fakultet
    City: 10000 - Zagreb, Croatia

COOPERATION - INSTITUTIONS


  1. Name of institution: Institut "Ruđer Bošković"
    Type of institution: University/Faculty
    City: 10000 - Zagreb, Croatia

  2. Name of institution: IREKS-AROMA
    Type of institution: State institute
    City: 10000 - Zagreb, Croatia

  3. Name of institution: Zavod za mikrobiologiju FBF-a
    Type of institution: Economical/Production
    City: 10000 - Zagreb, Croatia

  4. Name of institution: Zavod za farmakologiju FBF-a
    Type of institution: Economical/Production
    City: 10000 - Zagreb, Croatia

  5. Name of institution: Institut fur Pharmazeutische Biologie, Universitat Ludwig Maximillian
    Type of institution: University/Faculty
    Type of cooperation: Occasional exchange of experts
    City: Munchen, Njemačka

  6. Name of institution: Institut fur Pharmakognosie der Karl-Franzens-Universitat Graz
    Type of cooperation: Occasional exchange of information
    City: Graz, Austrija

OTHER ACHIEVEMENTS


  1. Name: Organiziranje SEMINARA IZ FITOFARMACIJE za farmaceute Hrvatske
    Type of achievement: Other
    Authors: Zdenka Kalođera,Nikola Kujundži',Gordana Stani', ĐurĆica Tarle, Željan Maleš
Other information about the project.
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